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Massive-AB-FAST anti-Tau (Sequence: FAST) FAST-DNA-PAINT Kit (Sequence: FAST) - MP2055

DNA-PAINT Neuro-Imaging Kit

ATTO 655 label, Sequence: FAST

This product was developed by   

 

This Massive Photonics DNA-PAINT Neuro-Imaging Kit is ready-to-use for the staining of the microtubule associated protein Tau using DNA-PAINT (DNA-Point Accumulation for Imaging in Nanoscale Topography). This localization based super-resolution microscopy method employs short, dye-labeled single stranded DNA that transiently binds its complementary sequences, which are attached to target-specific antibodies or nanobodies. Several Massive Photonics DNA-PAINT Neuro-Imaging Kits can be combined for multi-target staining and super-resolution imaging of various neuronal targets achieving visualization of cytoskeleton-associated and synaptic proteins with resolutions below 20 nm.

 

  • More details about super resolution microscopy with DNA-PAINT kits
  • Product specific DNA-PAINT protocols for Neuro-Imaging Kits are included
Cat. No.: MP2055
Amount: 1
Price: please inquire
Dear Customer,
thank you for your interest in our products. Our high-quality antibodies are featured in the DNA-PAINT Neuro-Imaging Kits, which are developed and distributed by Massive Photonics GmbH.

To ensure your request is handled efficiently, please use the provided input form to contact Massive Photonics directly.

With kind regards,
Your SYSY Antibodies Team
Applications
 
DNA-PAINT: yes gallery  

In antibody-based DNA-PAINT (Point Accumulation in Nanoscale Topography), a short oligomeric docking strand is coupled to a specific antibody. The transient association of the fluorophore to the antibody is mediated by the pairing of a short fluorescently labeled complementary imager DNA strand. DNA-PAINT allows super-resolution imaging and the imaging of a huge number of antibodies on the same biological sample in a single multiplex experiment. For additional experimental details refer to the Remarks section.
MASSIVE-AB-FAST anti-Tau-ATTO655

This kit provides ready-to-use binders for DNA-PAINT imaging of the neuronal microtubule associated protein Tau, which mainly localizes to axons. Also included are imager strands and buffers for sample preparation and imaging.

This kit contains a monoclonal antibody recognizing Tau (cat. no. 314 011) that has been preincubated with single-domain antibodies (sdABs) from NanoTag conjugated to FAST-DNA-PAINT sequence F5.
Label ATTO 655
Immunogen Recombinant protein corresponding to the N-terminal half of mouse Tau-D
Reactivity Reacts with: mouse (P10637), rat (P19332).
Other species not tested yet.
Cat. No.: MP2055
Amount: 1
Price: please inquire
Dear Customer,
thank you for your interest in our products. Our high-quality antibodies are featured in the DNA-PAINT Neuro-Imaging Kits, which are developed and distributed by Massive Photonics GmbH.

To ensure your request is handled efficiently, please use the provided input form to contact Massive Photonics directly.

With kind regards,
Your SYSY Antibodies Team
DNA-PAINT
Background

There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.
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