Cat. No.: 214 006
Amount: 200 µl
Price:
$370.00
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| Cat. No. 214 006 |
200 µl antibody, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Full-length recombinant human Calbindin D28k protein (UniProt Id: P05937) |
| Reactivity |
Reacts with: human (P05937), rat (P07171), mouse (P12658), monkey, ape, cow. Other species not tested yet. |
| Matching control protein/peptide | 214-0P |
| Remarks |
IHC-Fr: MeOH fixation is recommended. |
| Data sheet | 214_006.pdf |
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Calbindin D28k (CALB1, D28K or CAB27) and Calretinin (Calbindin D29k) are members of the EF-hand calcium-binding protein family, playing essential roles in intracellular calcium homeostasis, neuroprotection, and signal transduction (1). Calbindin D28k is widely expressed in tissues that experience high calcium influx, such as the brain, sensory organs, endocrine tissues, and the enteric nervous system (ENS). In the central nervous system (CNS), Calbindin D28k is an important marker for specific neuronal populations, particularly in Purkinje cells of the cerebellum and GABAergic and glutamatergic neurons of the cortex (2). Outside the CNS, Calbindin D28k plays crucial roles in non-neuronal tissues. In the retina, it contributes to photoreceptor function and calcium signaling (3). In the pancreas, it is present in α- and β-cells (4). Additionally, it was reported that 31% of myenteric neurons and up to 95% of submucosal neurons in the human ENS express calbindin, suggesting its involvement in both motor and secretory functions (5).