Synaptic Systems

Cat. No.: 135 303

Amount: 50 µg

Price: $465.00

Cat. No. 135 303	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 1000 up to 1 : 10000 (AP staining) (see remarks) gallery IP: yes ICC: 1 : 500 up to 1 : 10000 gallery IHC: 1 : 1000 gallery IHC-P: 1 : 500 gallery IHC-Fr: 1 : 500 (see remarks) DNA-PAINT: yes (see remarks) Clarity: yes EM: yes ELISA: yes (see remarks)
Immunogen	Recombinant protein corresponding to residues near the carboxy terminus of rat VGLUT 1 (UniProt Id: Q62634)
Reactivity	Reacts with: human (Q9P2U7), rat (Q62634), mouse (Q3TXX4), cow, goat, sheep, dog. Other species not tested yet.
Specificity	K.O. validated PubMed: 15103023
Matching control protein/peptide	135-3P
Remarks	This antibody is highly recommended as marker for glutamatergic nerve terminals. WB: VGLUT 1 aggregates after boiling, making it necessary to run SDS-PAGE with non-boiled samples. IHC-Fr: 5 min MeOH and PFA fixation are possible. DNA-PAINT: This antibody has been successfully used for DNA-PAINT application (see Unterauer et al., 2024; PMID: 38552614). ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 135 311 as capture antibody. The ELISA-protocol for membrane proteins is recommended.
Data sheet	135_303.pdf

References for VGLUT1 - 135 303

A new method for isolation and purification of fusion-competent inhibitory synaptic vesicles.
Gopal N, Leitz J, Wang C, Esquivies L, Pfuetzner RA, Brunger AT
Current research in physiology (2024) 7: 100121. 135 303 WB; tested species: mouse

The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls.
Costas-Insua C, Hermoso-López A, Moreno E, Montero-Fernández C, Álvaro-Blázquez A, Maroto IB, Sánchez-Ruiz A, Diez-Alarcia R, Blázquez C, Morales P, Canela EI, et al.
EMBO molecular medicine (2024) : . 135 303 WB; tested species: mouse

Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity.
Solana-Balaguer J, Campoy-Campos G, Martín-Flores N, Pérez-Sisqués L, Sitjà-Roqueta L, Kucukerden M, Gámez-Valero A, Coll-Manzano A, Martí E, Pérez-Navarro E, Alberch J, et al.
Journal of extracellular vesicles (2023) 129: e12355. 135 303 WB, ICC; tested species: rat

Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts.
Ng PY, Ribet ABP, Guo Q, Mullin BH, Tan JWY, Landao-Bassonga E, Stephens S, Chen K, Yuan J, Abudulai L, Bollen M, et al.
Nature communications (2023) 141: 906. 135 303 WB; tested species: mouse

Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus.
Lin PY, Chen LY, Jiang M, Trotter JH, Seigneur E, Südhof TC
Science advances (2023) 91: eadd8856. 135 303 WB; tested species: mouse

Suppression of exaggerated NMDAR activity by memantine treatment ameliorates neurological and behavioral deficits in aminopeptidase P1-deficient mice.
Bae YS, Yoon SH, Kim YS, Oh SP, Song WS, Cha JH, Kim MH
Experimental & molecular medicine (2022) : . 135 303 WB; tested species: mouse

Erinacine A attenuates glutamate transporter 1 downregulation and protects against ischemic brain injury.
Hsu PC, Lan YJ, Chen CC, Lee LY, Chen WP, Wang YC, Lee YH
Life sciences (2022) 306: 120833. 135 303 WB; tested species: mouse

Influenza A Virus (H1N1) Infection Induces Microglial Activation and Temporal Dysbalance in Glutamatergic Synaptic Transmission.
Düsedau HP, Steffen J, Figueiredo CA, Boehme JD, Schultz K, Erck C, Korte M, Faber-Zuschratter H, Smalla KH, Dieterich D, Kröger A, et al.
mBio (2021) 125: e0177621. 135 303 WB, FACS; tested species: mouse

Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice.
Prieto M, Folci A, Poupon G, Schiavi S, Buzzelli V, Pronot M, François U, Pousinha P, Lattuada N, Abelanet S, Castagnola S, et al.
Nature communications (2021) 121: 1557. 135 303 WB; tested species: mouse

NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia.
Gerace E, Cialdai F, Sereni E, Lana D, Nosi D, Giovannini MG, Monici M, Mannaioni G
Molecular neurobiology (2021) 5810: 5383-5395. 135 303 WB; tested species: rat

Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats.
Ren D, Li JN, Qiu XT, Wan FP, Wu ZY, Fan BY, Zhang MM, Chen T, Li H, Bai Y, Li YQ, et al.
Neuroscience bulletin (2021) : . 135 303 WB, IHC; tested species: rat

Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function.
Kawai M, Imaizumi K, Ishikawa M, Shibata S, Shinozaki M, Shibata T, Hashimoto S, Kitagawa T, Ago K, Kajikawa K, Shibata R, et al.
Cell reports (2021) 378: 110019. 135 303 WB; tested species: mouse

Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 135 303 WB; tested species: mouse

Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences.
Scheggi S, Guzzi F, Braccagni G, De Montis MG, Parenti M, Gambarana C
Molecular autism (2020) 111: 62. 135 303 WB; tested species: rat

Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage.
Yao W, Tambini MD, Liu X, D'Adamio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 135 303 WB; tested species: mouse

Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control.
Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA
eLife (2019) 8: . 135 303 WB; tested species: human

Glutamate, GABA and presynaptic markers involved in neurotransmission are differently affected by age in distinct mouse brain regions.
Rozycka A, Charzynska A, Misiewicz Z, Maciej Stępniewski T, Sobolewska A, Kossut M, Liguz-Lecznar M
ACS chemical neuroscience (2019) : . 135 303 WB; tested species: mouse

CNS synapses are stabilized trans-synaptically by laminins and laminin-interacting proteins.
Hunter DD, Manglapus MK, Bachay G, Claudepierre T, Dolan MW, Gesuelli KA, Brunken WJ
The Journal of comparative neurology (2019) 5271: 67-86. 135 303 WB, IHC; tested species: mouse

Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and Inhibitory Synapse Development and Abnormal Social Communication and Startle Response.
Li Y, Kim R, Cho YS, Song WS, Kim D, Kim K, Roh JD, Chung C, Park H, Yang E, Kim SJ, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3826: 5872-5887. 135 303 WB; tested species: mouse

UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism.
Trobiani L, Favaloro FL, Di Castro MA, Di Mattia M, Cariello M, Miranda E, Canterini S, De Stefano ME, Comoletti D, Limatola C, De Jaco A, et al.
Neurobiology of disease (2018) : . 135 303 WB; tested species: mouse

SNARE Complex-associated Proteins in the Lateral Amygdala of Macaca mullatta Following Long-term Ethanol Drinking.
Alexander NJ, Rau AR, Jimenez VA, Daunais JB, Grant KA, McCool BA
Alcoholism, clinical and experimental research (2018) : . 135 303 WB; tested species: monkey

A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 135 303 WB

Vesicular glutamate transporters play a role in neuronal differentiation of cultured SVZ-derived neural precursor cells.
Sánchez-Mendoza EH, Bellver-Landete V, Arce C, Doeppner TR, Hermann DM, Oset-Gasque MJ
PloS one (2017) 125: e0177069. 135 303 WB, ICC

Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission.
Sando R, Bushong E, Zhu Y, Huang M, Considine C, Phan S, Ju S, Uytiepo M, Ellisman M, Maximov A
Neuron (2017) 942: 312-321.e3. 135 303 WB, IHC; tested species: mouse

Reorganization of Synaptic Connections and Perineuronal Nets in the Deep Cerebellar Nuclei of Purkinje Cell Degeneration Mutant Mice.
Blosa M, Bursch C, Weigel S, Holzer M, Jäger C, Janke C, Matthews RT, Arendt T, Morawski M
Neural plasticity (2016) 2016: 2828536. 135 303 IHC, WB; tested species: mouse

Altered sensory processing and dendritic remodeling in hyperexcitable visual cortical networks.
Vannini E, Restani L, Pietrasanta M, Panarese A, Mazzoni A, Rossetto O, Middei S, Micera S, Caleo M
Brain structure & function (2016) 2216: 2919-36. 135 303 WB

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.
Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T
Scientific reports (2016) 6: 23969. 135 303 WB, ICC

Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo.
Jedlicka P, Vnencak M, Krueger DD, Jungenitz T, Brose N, Schwarzacher SW
Brain structure & function (2015) 2201: 47-58. 135 303 WB

mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.
Wentzel C, Sommer JE, Nair R, Stiefvater A, Sibarita JB, Scheiffele P
Neuron (2013) 786: 1012-23. 135 303 WB, ICC; tested species: mouse

Ongoing intrinsic synchronous activity is required for the functional maturation of CA3-CA1 glutamatergic synapses.
Huupponen J, Molchanova SM, Lauri SE, Taira T
Cerebral cortex (New York, N.Y. : 1991) (2013) 2311: 2754-64. 135 303 WB; tested species: rat

SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.
Iijima T, Wu K, Witte H, Hanno-Iijima Y, Glatter T, Richard S, Scheiffele P
Cell (2011) 1477: 1601-14. 135 303 ICC, IHC, WB; tested species: mouse

Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease.
Van Broeck B, Chen JM, Tréton G, Desmidt M, Hopf C, Ramsden N, Karran E, Mercken M, Rowley A
British journal of pharmacology (2011) 1632: 375-89. 135 303 WB; tested species: mouse

Transient focal cerebral ischemia significantly alters not only EAATs but also VGLUTs expression in rats: relevance of changes in reactive astroglia.
Sánchez-Mendoza E, Burguete MC, Castelló-Ruiz M, González MP, Roncero C, Salom JB, Arce C, Cañadas S, Torregrosa G, Alborch E, Oset-Gasque MJ, et al.
Journal of neurochemistry (2010) 1135: 1343-55. 135 303 IHC, WB; tested species: rat

Unique luminal localization of VGAT-C terminus allows for selective labeling of active cortical GABAergic synapses.
Martens H, Weston MC, Boulland JL, Grønborg M, Grosche J, Kacza J, Hoffmann A, Matteoli M, Takamori S, Harkany T, Chaudhry FA, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2008) 2849: 13125-31. 135 303 WB; tested species: rat

Synaptic and vesicular co-localization of the glutamate transporters VGLUT1 and VGLUT2 in the mouse hippocampus.
Herzog E, Takamori S, Jahn R, Brose N, Wojcik SM
Journal of neurochemistry (2006) 993: 1011-8. 135 303 IHC, IP, WB; tested species: mouse

Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2005) 956: 1732-45. 135 303 WB; tested species: rat

An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size.
Wojcik SM, Rhee JS, Herzog E, Sigler A, Jahn R, Takamori S, Brose N, Rosenmund C
Proceedings of the National Academy of Sciences of the United States of America (2004) 10118: 7158-63. 135 303 ICC, WB, IHC; KO verified; tested species: mouse

3D bioprinting of human neural tissues with functional connectivity.
Yan Y, Li X, Gao Y, Mathivanan S, Kong L, Tao Y, Dong Y, Li X, Bhattacharyya A, Zhao X, Zhang SC, et al.
Cell stem cell (2024) 312: 260-274.e7. 135 303 ICC; tested species: human

Repetitive CREB-DNA interactions at gene loci predetermined by CBP induce activity-dependent gene expression in human cortical neurons.
Atsumi Y, Iwata R, Kimura H, Vanderhaeghen P, Yamamoto N, Sugo N
Cell reports (2024) 431: 113576. 135 303 ICC; tested species: human

Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression.
Guhathakurta D, Petrušková A, Akdaş EY, Perelló-Amorós B, Frischknecht R, Anni D, Weiss EM, Walter M, Fejtová A
Translational psychiatry (2024) 141: 47. 135 303 ICC; tested species: rat

Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses.
Song SH, Augustine GJ
Cell reports (2023) 428: 113004. 135 303 ICC; tested species: mouse

An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission.
Daniel JA, Elizarova S, Shaib AH, Chouaib AA, Magnussen HM, Wang J, Brose N, Rhee J, Tirard M
Frontiers in molecular neuroscience (2023) 16: 1115880. 135 303 ICC; tested species: mouse

Characterization of a Human Neuronal Culture System for the Study of Cofilin-Actin Rod Pathology.
Tahtamouni LH, Alderfer SA, Kuhn TB, Minamide LS, Chanda S, Ruff MR, Bamburg JR
Biomedicines (2023) 1111: . 135 303 ICC; tested species: human

Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells.
Tao Y, Li X, Dong Q, Kong L, Petersen AJ, Yan Y, Xu K, Zima S, Li Y, Schmidt DK, Ayala M, et al.
Nature biotechnology (2023) : . 135 303 ICC; tested species: human

LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.
Fazel Darbandi S, Nelson AD, Pai EL, Bender KJ, Rubenstein JLR
Journal of neurodevelopmental disorders (2022) 141: 11. 135 303 ICC; tested species: mouse

Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3.
Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, et al.
Neuron (2022) : . 135 303 ICC, EM; tested species: rat

Multilayered regulations of alternative splicing, NMD, and protein stability control temporal induction and tissue-specific expression of TRIM46 during axon formation.
Vuong JK, Ergin V, Chen L, Zheng S
Nature communications (2022) 131: 2081. 135 303 ICC; tested species: mouse

Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain.
Tibbe D, Ferle P, Krisp C, Nampoothiri S, Mirzaa G, Assaf M, Parikh S, Kutsche K, Kreienkamp HJ
Life science alliance (2022) 510: . 135 303 ICC; tested species: rat

Establishment of autaptic culture with human-induced pluripotent stem cell-derived astrocytes.
Uchino K, Tanaka Y, Kawaguchi S, Kubota K, Watanabe T, Katsurabayashi S, Hirose S, Iwasaki K
iScience (2022) 258: 104762. 135 303 ICC; tested species: human

The function of FUS in neurodevelopment revealed by the brain and spinal cord organoids.
Zou H, Wang JY, Ma GM, Xu MM, Luo F, Zhang L, Wang WY
Molecular and cellular neurosciences (2022) 123: 103771. 135 303 ICC; tested species: human

Human iPSC-Derived Cortical Neurons Display Homeostatic Plasticity.
Cordella F, Ferrucci L, D'Antoni C, Ghirga S, Brighi C, Soloperto A, Gigante Y, Ragozzino D, Bezzi P, Di Angelantonio S
Life (Basel, Switzerland) (2022) 1211: . 135 303 ICC; tested species: human

Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs.
Brighi C, Salaris F, Soloperto A, Cordella F, Ghirga S, de Turris V, Rosito M, Porceddu PF, D'Antoni C, Reggiani A, Rosa A, et al.
Cell death & disease (2021) 125: 498. 135 303 ICC; tested species: human

Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment.
Dong X, Yang L, Liu K, Ji X, Tang C, Li W, Ma L, Mei Y, Peng T, Feng B, Wu Z, et al.
Cell reports (2021) 349: 108802. 135 303 ICC; tested species: human

DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons.
Bachmann S, Linde J, Bell M, Spehr M, Zempel H, Zimmer-Bensch G
International journal of molecular sciences (2021) 224: . 135 303 ICC; tested species: human

Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation.
Anni D, Weiss EM, Guhathakurta D, Akdas YE, Klueva J, Zeitler S, Andres-Alonso M, Huth T, Fejtova A
Cellular and molecular life sciences : CMLS (2021) : . 135 303 ICC; tested species: rat

Astrocytes in stress accumulate lipid droplets.
Smolič T, Tavčar P, Horvat A, Černe U, Halužan Vasle A, Tratnjek L, Kreft ME, Scholz N, Matis M, Petan T, Zorec R, et al.
Glia (2021) 696: 1540-1562. 135 303 ICC; tested species: rat

Amyloid-β precursor protein processing and oxidative stress are altered in human iPSC-derived neuron and astrocyte co-cultures carrying presenillin-1 gene mutations following spontaneous differentiation.
Elsworthy RJ, King MC, Grainger A, Fisher E, Crowe JA, Alqattan S, Ludlam A, Hill DEJ, Aldred S
Molecular and cellular neurosciences (2021) 114: 103631. 135 303 ICC; tested species: human

Distinct Expression of SLM2 Underlies Splicing-Dependent Trans-Synaptic Signaling of Neurexin Across GABAergic Neuron Subtypes.
Sato Y, Iijima Y, Darwish M, Sato T, Iijima T
Neurochemical research (2021) : . 135 303 ICC; tested species: mouse

The novel mitochondria activator, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), promotes the development of hippocampal neuronal morphology.
Katsurabayashi S, Oyabu K, Kubota K, Watanabe T, Nagamatsu T, Akaike N, Iwasaki K
Biochemical and biophysical research communications (2021) 560: 146-151. 135 303 ICC; tested species: mouse

Interaction and Subcellular Association of PRRT1/SynDIG4 With AMPA Receptors.
Martin EE, Wleklinski E, Hoang HTM, Ahmad M
Frontiers in synaptic neuroscience (2021) 13: 705664. 135 303 ICC; tested species: rat

A modular brain-on-a-chip for modelling epileptic seizures with functionally connected human neuronal networks.
Pelkonen A, Mzezewa R, Sukki L, Ryynänen T, Kreutzer J, Hyvärinen T, Vinogradov A, Aarnos L, Lekkala J, Kallio P, Narkilahti S, et al.
Biosensors & bioelectronics (2020) 168: 112553. 135 303 ICC; tested species: human

Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration.
Socodato R, Portugal CC, Canedo T, Rodrigues A, Almeida TO, Henriques JF, Vaz SH, Magalhães J, Silva CM, Baptista FI, Alves RL, et al.
Cell reports (2020) 3112: 107796. 135 303 ICC, IHC; tested species: mouse,rat

Missense mutations in CASK interfere with neurexin binding and neurexin-induced oligomerization.
Pan YE, Tibbe D, Harms FL, Reißner C, Becker K, Dingmann B, Mirzaa G, Kattentidt-Mouravieva AA, Shoukier M, Aggarwal S, Missler M, et al.
Journal of neurochemistry (2020) : . 135 303 ICC; tested species: rat

High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons.
Cavallo F, Troglio F, Fagà G, Fancelli D, Shyti R, Trattaro S, Zanella M, D'Agostino G, Hughes JM, Cera MR, Pasi M, et al.
Molecular autism (2020) 111: 88. 135 303 ICC; tested species: human

Astragaloside IV and echinacoside benefit neuronal properties via direct effects and through upregulation of SOD1 astrocyte function in vitro.
Tian Y, Jin S, Promes V, Liu X, Zhang Y
Naunyn-Schmiedeberg's archives of pharmacology (2020) : . 135 303 ICC; tested species: mouse

A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids.
Renner H, Grabos M, Becker KJ, Kagermeier TE, Wu J, Otto M, Peischard S, Zeuschner D, TsyTsyura Y, Disse P, Klingauf J, et al.
eLife (2020) 9: . 135 303 ICC; tested species: human

Cohen Syndrome Patient iPSC-Derived Neurospheres and Forebrain-Like Glutamatergic Neurons Reveal Reduced Proliferation of Neural Progenitor Cells and Altered Expression of Synapse Genes.
Lee YK, Hwang SK, Lee SK, Yang JE, Kwak JH, Seo H, Ahn H, Lee YS, Kim J, Lim CS, Kaang BK, et al.
Journal of clinical medicine (2020) 96: . 135 303 ICC; tested species: human

LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ.
Roppongi RT, Dhume SH, Padmanabhan N, Silwal P, Zahra N, Karimi B, Bomkamp C, Patil CS, Champagne-Jorgensen K, Twilley RE, Zhang P, et al.
Neuron (2020) : . 135 303 ICC, IHC; tested species: mouse

A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α-dystroglycan.
Kim J, Lana B, Torelli S, Ryan D, Catapano F, Ala P, Luft C, Stevens E, Konstantinidis E, Louzada S, Fu B, et al.
EMBO reports (2019) : e47967. 135 303 ICC; tested species: human

A Simple DMSO-Based Method for Cryopreservation of Primary Hippocampal and Cortical Neurons.
Ishizuka Y, Bramham CR
Journal of neuroscience methods (2019) : 108578. 135 303 ICC; tested species: rat

SNAP-25 phosphorylation at Ser187 is not involved in Ca2+ or phorbolester-dependent potentiation of synaptic release.
Ruiter M, Houy S, Engholm-Keller K, Graham ME, Sørensen JB
Molecular and cellular neurosciences (2019) : 103452. 135 303 ICC; tested species: mouse

TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.
Moretto E, Longatti A, Murru L, Chamma I, Sessa A, Zapata J, Hosy E, Sainlos M, Saint-Pol J, Rubinstein E, Choquet D, et al.
Cell reports (2019) 295: 1130-1146.e8. 135 303 ICC; tested species: mouse

High-Aspect-Ratio Semiconducting Polymer Pillars for 3D Cell Cultures.
Tullii G, Giona F, Lodola F, Bonfadini S, Bossio C, Varo S, Desii A, Criante L, Sala C, Pasini M, Verpelli C, et al.
ACS applied materials & interfaces (2019) : . 135 303 ICC; tested species: rat

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, et al.
Science (New York, N.Y.) (2018) : . 135 303 ICC; tested species: rat

A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration.
Grillo FW, Neves G, Walker A, Vizcay-Barrena G, Fleck RA, Branco T, Burrone J
Neuron (2018) : . 135 303 ICC; tested species: rat

Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells.
Sunamura N, Iwashita S, Enomoto K, Kadoshima T, Isono F
Scientific reports (2018) 81: 11585. 135 303 ICC; tested species: human

Isolation of Synaptic Vesicles from Genetically Engineered Cultured Neurons.
McKenzie C, Spanova M, Johnson A, Kainrath S, Zheden V, Sitte HH, Janovjak H
Journal of neuroscience methods (2018) : . 135 303 ICC; tested species: rat

Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships.
Zhang P, Lu H, Peixoto RT, Pines MK, Ge Y, Oku S, Siddiqui TJ, Xie Y, Wu W, Archer-Hartmann S, Yoshida K, et al.
Cell (2018) : . 135 303 ICC; tested species: rat

The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling.
Tu YK, Duman JG, Tolias KF
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3839: 8388-8406. 135 303 ICC; tested species: rat

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Nature chemical biology (2017) 132: 153-160. 135 303 ICC; tested species: mouse

Enhanced Axonal Extension of Subcortical Projection Neurons Isolated from Murine Embryonic Cortex using Neuropilin-1.
Sano N, Shimogawa T, Sakaguchi H, Ioroi Y, Miyawaki Y, Morizane A, Miyamoto S, Takahashi J
Frontiers in cellular neuroscience (2017) 11: 123. 135 303 ICC; tested species: mouse

The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, et al.
Cell (2017) 1681-2: 295-310.e19. 135 303 ICC, IHC; tested species: mouse

Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 135 303 ICC; tested species: mouse

Neuronal activity controls transsynaptic geometry.
Glebov OO, Cox S, Humphreys L, Burrone J
Scientific reports (2016) 6: 22703. 135 303 ICC

Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission.
Katsurabayashi S, Kawano H, Ii M, Nakano S, Tatsumi C, Kubota K, Takasaki K, Mishima K, Fujiwara M, Iwasaki K
Physiological reports (2016) 41: . 135 303 ICC

CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.
Farina M, van de Bospoort R, He E, Persoon CM, van Weering JR, Broeke JH, Verhage M, Toonen RF
eLife (2015) 4: . 135 303 ICC

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport.
Freibaum BD, Lu Y, Lopez-Gonzalez R, Kim NC, Almeida S, Lee KH, Badders N, Valentine M, Miller BL, Wong PC, Petrucelli L, et al.
Nature (2015) 5257567: 129-33. 135 303 ICC

Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors.
Andreae LC, Burrone J
Cell reports (2015) : . 135 303 ICC

Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons.
Harrill JA, Chen H, Streifel KM, Yang D, Mundy WR, Lein PJ
Molecular brain (2015) 8: 10. 135 303 ICC

Borna disease virus phosphoprotein impairs the developmental program controlling neurogenesis and reduces human GABAergic neurogenesis.
Scordel C, Huttin A, Cochet-Bernoin M, Szelechowski M, Poulet A, Richardson J, Benchoua A, Gonzalez-Dunia D, Eloit M, Coulpier M
PLoS pathogens (2015) 114: e1004859. 135 303 ICC

Evaluation of established human iPSC-derived neurons to model neurodegenerative diseases.
Meneghello G, Verheyen A, Van Ingen M, Kuijlaars J, Tuefferd M, Van Den Wyngaert I, Nuydens R
Neuroscience (2015) 301: 204-12. 135 303 ICC; tested species: human

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.
Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, et al.
Nature (2015) 5257567: 56-61. 135 303 ICC; tested species: human

BDNF enhances spontaneous and activity-dependent neurotransmitter release at excitatory terminals but not at inhibitory terminals in hippocampal neurons.
Shinoda Y, Ahmed S, Ramachandran B, Bharat V, Brockelt D, Altas B, Dean C
Frontiers in synaptic neuroscience (2014) 6: 27. 135 303 ICC; tested species: rat

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.
Etemad S, Obermair GJ, Bindreither D, Benedetti A, Stanika R, Di Biase V, Burtscher V, Koschak A, Kofler R, Geley S, Wille A, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 344: 1446-61. 135 303 ICC; tested species: mouse

High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons.
Andreska T, Aufmkolk S, Sauer M, Blum R
Frontiers in cellular neuroscience (2014) 8: 107. 135 303 ICC; tested species: mouse

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC
The Journal of cell biology (2013) 2016: 915-28. 135 303 ICC; tested species: rat

Neuronal synapse formation induced by microglia and interleukin 10.
Lim SH, Park E, You B, Jung Y, Park AR, Park SG, Lee JR
PloS one (2013) 811: e81218. 135 303 ICC

Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis.
Popescu IR, Nicaise C, Liu S, Bisch G, Knippenberg S, Daubie V, Bohl D, Pochet R
Stem cells translational medicine (2013) 23: 167-74. 135 303 ICC; tested species: human

Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.
Murata Y, Constantine-Paton M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3311: 5040-52. 135 303 ICC; tested species: mouse,rat

Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.
Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, et al.
PloS one (2013) 810: e76055. 135 303 ICC

Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.
Cao P, Maximov A, Südhof TC
Cell (2011) 1452: 300-11. 135 303 ICC, IHC; tested species: mouse

Single particle tracking of alpha7 nicotinic AChR in hippocampal neurons reveals regulated confinement at glutamatergic and GABAergic perisynaptic sites.
Bürli T, Baer K, Ewers H, Sidler C, Fuhrer C, Fritschy JM
PloS one (2010) 57: e11507. 135 303 ICC

Immunolocalization of BK channels in hippocampal pyramidal neurons.
Sailer CA, Kaufmann WA, Kogler M, Chen L, Sausbier U, Ottersen OP, Ruth P, Shipston MJ, Knaus HG
The European journal of neuroscience (2006) 242: 442-54. 135 303 ICC; tested species: mouse

A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brain.
Charych EI, Yu W, Li R, Serwanski DR, Miralles CP, Li X, Yang BY, Pinal N, Walikonis R, De Blas AL
The Journal of biological chemistry (2004) 27937: 38978-90. 135 303 ICC; tested species: rat

[A case from practice (164). Acute unilateral vestibular deficit on the left].
Ludwig-Hagemann R
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis (1990) 7910: 303-4. 135 303 ICC; tested species: rat

The proteomic landscape of synaptic diversity across brain regions and cell types.
van Oostrum M, Blok TM, Giandomenico SL, Tom Dieck S, Tushev G, Fürst N, Langer JD, Schuman EM
Cell (2023) 18624: 5411-5427.e23. 135 303 IHC; tested species: mouse

Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury.
Aljović A, Jacobi A, Marcantoni M, Kagerer F, Loy K, Kendirli A, Bräutigam J, Fabbio L, Van Steenbergen V, Pleśniar K, Kerschensteiner M, et al.
EMBO molecular medicine (2023) : e16111. 135 303 IHC; tested species: mouse

Tsc1 Loss in VIP-Lineage Cortical Interneurons Results in More VIP+ Interneurons and Enhanced Excitability.
Hu JS, Malik R, Sohal VS, Rubenstein JL, Vogt D
Cells (2023) 131: . 135 303 IHC; tested species: mouse

Collagen XIX is required for pheromone recognition and glutamatergic synapse formation in mouse accessory olfactory bulb.
Amos C, Fox MA, Su J
Frontiers in cellular neuroscience (2023) 17: 1157577. 135 303 IHC; tested species: mouse

Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells.
Jun S, Kim M, Park H, Hwang E, Yamamoto Y, Tanaka-Yamamoto K
Cell reports (2023) 429: 113137. 135 303 IHC; tested species: mouse

Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1.
Pilotto F, Douthwaite C, Diab R, Ye X, Al Qassab Z, Tietje C, Mounassir M, Odriozola A, Thapa A, Buijsen RAM, Lagache S, et al.
Neuron (2023) : . 135 303 IHC; tested species: mouse

Most dystrophic neurites in the common 5xFAD Alzheimer mouse model originate from axon terminals.
Mabrouk R, Miettinen PO, Tanila H
Neurobiology of disease (2023) 182: 106150. 135 303 IHC; tested species: mouse

Multi-synaptic boutons are a feature of CA1 hippocampal connections in the stratum oriens.
Rigby M, Grillo FW, Compans B, Neves G, Gallinaro J, Nashashibi S, Horton S, Pereira Machado PM, Carbajal MA, Vizcay-Barrena G, Levet F, et al.
Cell reports (2023) 425: 112397. 135 303 IHC; tested species: mouse

The β2V287L nicotinic subunit linked to sleep-related epilepsy differently affects fast-spiking and regular spiking somatostatin-expressing neurons in murine prefrontal cortex.
Meneghini S, Modena D, Colombo G, Coatti A, Milani N, Madaschi L, Amadeo A, Becchetti A
Progress in neurobiology (2022) : 102279. 135 303 IHC; tested species: mouse

Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection.
Nogueira-Rodrigues J, Leite SC, Pinto-Costa R, Sousa SC, Luz LL, Sintra MA, Oliveira R, Monteiro AC, Pinheiro GG, Vitorino M, Silva JA, et al.
Developmental cell (2022) 574: 440-450.e7. 135 303 IHC; tested species: mouse

Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation.
Katayama KI, Morimura N, Kobayashi K, Corbett D, Okamoto T, Ornthanalai VG, Matsunaga H, Fujita W, Matsumoto Y, Akagi T, Hashikawa T, et al.
iScience (2022) 257: 104604. 135 303 IHC; tested species: mouse

Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks.
Muinos-Bühl A, Rombo R, Janzen E, Ling KK, Hupperich K, Rigo F, Bennett CF, Wirth B
Neurobiology of disease (2022) 171: 105795. 135 303 IHC; tested species: mouse

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration.
Welch GM, Boix CA, Schmauch E, Davila-Velderrain J, Victor MB, Dileep V, Bozzelli PL, Su Q, Cheng JD, Lee A, Leary NS, et al.
Science advances (2022) 839: eabo4662. 135 303 IHC; tested species: mouse

Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys.
Tao Y, Vermilyea SC, Zammit M, Lu J, Olsen M, Metzger JM, Yao L, Chen Y, Phillips S, Holden JE, Bondarenko V, et al.
Nature medicine (2021) 274: 632-639. 135 303 IHC; tested species: monkey

Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice.
Wu H, Petitpré C, Fontanet P, Sharma A, Bellardita C, Quadros RM, Jannig PR, Wang Y, Heimel JA, Cheung KKY, Wanderoy S, et al.
Nature communications (2021) 121: 1026. 135 303 IHC; tested species: mouse

Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors.
Kweon H, Jung WB, Im GH, Ryoo J, Lee JH, Do H, Choi Y, Song YH, Jung H, Park H, Qiu LR, et al.
Cell reports (2021) 348: 108780. 135 303 IHC; tested species: mouse

Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus.
Zhang L, Wu C, Martel DT, West M, Sutton MA, Shore SE
Neural plasticity (2021) 2021: 8833087. 135 303 IHC

Transmitter and ion channel profiles of neurons in the primate abducens and trochlear nuclei.
Mayadali ÜS, Fleuriet J, Mustari M, Straka H, Horn AKE
Brain structure & function (2021) : . 135 303 IHC; tested species: monkey

Maternal Deprivation in Rats Decreases the Expression of Interneuron Markers in the Neocortex and Hippocampus.
Aksic M, Poleksic J, Aleksic D, Petronijevic N, Radonjic NV, Jakovcevski M, Kapor S, Divac N, Filipovic BR, Jakovcevski I
Frontiers in neuroanatomy (2021) 15: 670766. 135 303 IHC; tested species: rat

Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury.
Prager J, Ito D, Carwardine DR, Jiju P, Chari DM, Granger N, Wong LF
Experimental neurology (2021) 340: 113660. 135 303 IHC; tested species: rat

Induction of inverted morphology in brain organoids by vertical-mixing bioreactors.
Suong DNA, Imamura K, Inoue I, Kabai R, Sakamoto S, Okumura T, Kato Y, Kondo T, Yada Y, Klein WL, Watanabe A, et al.
Communications biology (2021) 41: 1213. 135 303 IHC; tested species: human

Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity.
Ciarpella F, Zamfir RG, Campanelli A, Ren E, Pedrotti G, Bottani E, Borioli A, Caron D, Di Chio M, Dolci S, Ahtiainen A, et al.
iScience (2021) 2412: 103438. 135 303 IHC; tested species: mouse

Nanoscale 3D EM reconstructions reveal intrinsic mechanisms of structural diversity of chemical synapses.
Zhu Y, Uytiepo M, Bushong E, Haberl M, Beutter E, Scheiwe F, Zhang W, Chang L, Luu D, Chui B, Ellisman M, et al.
Cell reports (2021) 351: 108953. 135 303 IHC; tested species: mouse

Muscarinic Acetylcholine Receptor Localization on Distinct Excitatory and Inhibitory Neurons Within the ACC and LPFC of the Rhesus Monkey.
Tsolias A, Medalla M
Frontiers in neural circuits (2021) 15: 795325. 135 303 IHC; tested species: monkey

TDP-43 proteinopathy occurs independently of autophagic substrate accumulation and underlies nuclear defects in Niemann-Pick C disease.
Liu EA, Mori E, Hamasaki F, Lieberman AP
Neuropathology and applied neurobiology (2021) 477: 1019-1032. 135 303 IHC; tested species: mouse

Spinal Reflex Recovery after Dorsal Rhizotomy and Repair with Platelet-Rich Plasma (PRP) Gel Combined with Bioengineered Human Embryonic Stem Cells (hESCs).
de Castro MV, da Silva MVR, Chiarotto GB, Santana MHA, Luzo ÂCM, Kyrylenko S, de Oliveira ALR
Stem cells international (2020) 2020: 8834360. 135 303 IHC; tested species: rat

Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants.
Fazel Darbandi S, Robinson Schwartz SE, Pai EL, Everitt A, Turner ML, Cheyette BNR, Willsey AJ, State MW, Sohal VS, Rubenstein JLR
Cell reports (2020) 312: 107495. 135 303 IHC; tested species: mouse

Microglia Dynamics and Interactions with Motoneurons Axotomized After Nerve Injuries Revealed By Two-Photon Imaging.
Rotterman TM, Alvarez FJ
Scientific reports (2020) 101: 8648. 135 303 IHC; tested species: mouse

Paracrine Role for Somatostatin Interneurons in the Assembly of Perisomatic Inhibitory Synapses.
Su J, Basso D, Iyer S, Su K, Wei J, Fox MA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 135 303 IHC; tested species: mouse

Slow Waves Promote Sleep-Dependent Plasticity and Functional Recovery after Stroke.
Facchin L, Schöne C, Mensen A, Bandarabadi M, Pilotto F, Saxena S, Libourel PA, Bassetti CLA, Adamantidis AR
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4045: 8637-8651. 135 303 IHC; tested species: mouse

VMHvl-Projecting Vglut1+ Neurons in the Posterior Amygdala Gate Territorial Aggression.
Zha X, Wang L, Jiao ZL, Yang RR, Xu C, Xu XH
Cell reports (2020) 313: 107517. 135 303 IHC; tested species: mouse

Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice.
Klaus C, Hansen JN, Ginolhac A, Gérard D, Gnanapragassam VS, Horstkorte R, Rossdam C, Buettner FFR, Sauter T, Sinkkonen L, Neumann H, et al.
Neurobiology of aging (2020) 88: 91-107. 135 303 IHC; tested species: mouse

Human gestational NMDAR autoantibodies impair neonatal murine brain function.
Jurek B, Chayka M, Kreye J, Lang K, Kraus L, Fidzinski P, Kornau HC, Dao LM, Wenke NK, Long M, Rivalan M, et al.
Annals of neurology (2019) : . 135 303 IHC; tested species: mouse

Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain.
Park J, Park SJ, Kim S
Molecular brain (2019) 121: 58. 135 303 IHC; tested species: mouse

Toll-like receptor 4 (TLR4) influences the glial reaction in the spinal cord and the neural response to injury following peripheral nerve crush.
Ribeiro P, Castro MV, Perez M, Cartarozzi LP, Spejo AB, Chiarotto GB, Augusto TM, Oliveira ALR
Brain research bulletin (2019) : . 135 303 IHC; tested species: mouse

Increased severity of the CHIMERA model induces acute vascular injury, sub-acute deficits in memory recall, and chronic white matter gliosis.
Bashir A, Abebe ZA, McInnes KA, Button EB, Tatarnikov I, Cheng WH, Haber M, Wilkinson A, Barron C, Diaz-Arrastia R, Stukas S, et al.
Experimental neurology (2019) 324: 113116. 135 303 IHC; tested species: mouse

VGluT1 Deficiency Impairs Visual Attention and Reduces the Dynamic Range of Short-Term Plasticity at Corticothalamic Synapses.
Lindström SH, Sundberg SC, Larsson M, Andersson FK, Broman J, Granseth B
Cerebral cortex (New York, N.Y. : 1991) (2019) : . 135 303 IHC, EM; tested species: mouse

Loss of PTEN-induced kinase 1 (Pink1) reduces hippocampal tyrosine hydroxylase and impairs learning and memory.
Maynard ME, Redell JB, Kobori N, Underwood EL, Fischer TD, Hood KN, LaRoche V, Waxham MN, Moore AN, Dash PK
Experimental neurology (2019) 323: 113081. 135 303 IHC; tested species: mouse

Inputs from Sequentially Developed Parallel Fibers Are Required for Cerebellar Organization.
Park H, Kim T, Kim J, Yamamoto Y, Tanaka-Yamamoto K
Cell reports (2019) 2811: 2939-2954.e5. 135 303 IHC; tested species: mouse

Reflex arc recovery after spinal cord dorsal root repair with platelet rich plasma (PRP).
de Castro MV, da Silva MVR, Chiarotto GB, Volpe BB, Santana MH, Malheiros Luzo ÂC, de Oliveira ALR
Brain research bulletin (2019) : . 135 303 IHC; tested species: rat

Self-Organized Synchronous Calcium Transients in a Cultured Human Neural Network Derived from Cerebral Organoids.
Sakaguchi H, Ozaki Y, Ashida T, Matsubara T, Oishi N, Kihara S, Takahashi J
Stem cell reports (2019) : . 135 303 IHC; tested species: human

Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection.
Adaikkan C, Middleton SJ, Marco A, Pao PC, Mathys H, Kim DN, Gao F, Young JZ, Suk HJ, Boyden ES, McHugh TJ, et al.
Neuron (2019) : . 135 303 IHC; tested species: mouse

Spinal motor circuit synaptic plasticity after peripheral nerve injury depends on microglia activation and a CCR2 mechanism.
Rotterman TM, Akhter ET, Lane AR, MacPherson KP, Garcia VV, Tansey MG, Alvarez FJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 135 303 IHC; tested species: mouse

Carnosic acid improves outcome after repetitive mild traumatic brain injury.
Maynard ME, Underwood EL, Redell JB, Zhao J, Kobori N, Hood KN, Moore AN, Dash PK
Journal of neurotrauma (2019) : . 135 303 IHC; tested species: mouse

Inositol polyphosphate multikinase mediates extinction of fear memory.
Park J, Longo F, Park SJ, Lee S, Bae M, Tyagi R, Han JH, Kim S, Santini E, Klann E, Snyder SH, et al.
Proceedings of the National Academy of Sciences of the United States of America (2019) : . 135 303 IHC; tested species: mouse

Botulinum Neurotoxin Application to the Severed Femoral Nerve Modulates Spinal Synaptic Responses to Axotomy and Enhances Motor Recovery in Rats.
Irintchev M, Guntinas-Lichius O, Irintchev A
Neural plasticity (2018) 2018: 7975013. 135 303 IHC; tested species: rat

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington's Disease.
Cabezas-Llobet N, Vidal-Sancho L, Masana M, Fournier A, Alberch J, Vaudry D, Xifró X
Molecular neurobiology (2018) : . 135 303 IHC; tested species: mouse

Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity.
Fazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, et al.
Neuron (2018) 1004: 831-845.e7. 135 303 IHC; tested species: mouse

Anterior cingulate cortex and its input to the basolateral amygdala control innate fear response.
Jhang J, Lee H, Kang MS, Lee HS, Park H, Han JH
Nature communications (2018) 91: 2744. 135 303 IHC; tested species: mouse

Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement.
Cheadle L, Tzeng CP, Kalish BT, Harmin DA, Rivera S, Ling E, Nagy MA, Hrvatin S, Hu L, Stroud H, Burkly LC, et al.
Neuron (2018) : . 135 303 IHC; tested species: mouse

Age-related loss of VGLUT1 excitatory, but not VGAT inhibitory, immunoreactive terminals on motor neurons in spinal cords of old sarcopenic male mice.
Krishnan VS, Shavlakadze T, Grounds MD, Hodgetts SI, Harvey AR
Biogerontology (2018) : . 135 303 IHC; tested species: mouse

Combining mGRASP and Optogenetics Enables High-Resolution Functional Mapping of Descending Cortical Projections.
Song JH, Lucaci D, Calangiu I, Brown MTC, Park JS, Kim J, Brickley SG, Chadderton P
Cell reports (2018) 244: 1071-1080. 135 303 IHC; tested species: mouse

Synapse preservation and decreased glial reactions following ventral root crush (VRC) and treatment with 4-hydroxy-tempo (TEMPOL).
Spejo AB, Teles CB, Zuccoli GDS, Oliveira ALR
Journal of neuroscience research (2018) : . 135 303 IHC; tested species: rat

Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice.
Ozek C, Krolewski RC, Buchanan SM, Rubin LL
Scientific reports (2018) 81: 17293. 135 303 IHC; tested species: mouse

Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory Synapse.
Chen C, Arai I, Satterfield R, Young SM, Jonas P
Cell reports (2017) 183: 723-736. 135 303 IHC

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Vanden Eynden E, et al.
Neuron (2017) 935: 1066-1081.e8. 135 303 IHC; tested species: human,mouse

Organization of the Claustrum-to-Entorhinal Cortical Connection in Mice.
Kitanishi T, Matsuo N
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 372: 269-280. 135 303 IHC; tested species: rat

Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories.
Roy DS, Kitamura T, Okuyama T, Ogawa SK, Sun C, Obata Y, Yoshiki A, Tonegawa S
Cell (2017) 1705: 1000-1012.e19. 135 303 IHC; tested species: mouse

Vesicular Glutamate Transporter 1 Knockdown in Infralimbic Prefrontal Cortex Augments Neuroendocrine Responses to Chronic Stress in Male Rats.
Myers B, McKlveen JM, Morano R, Ulrich-Lai YM, Solomon MB, Wilson SP, Herman JP
Endocrinology (2017) 15810: 3579-3591. 135 303 IHC; KD verified; tested species: rat

Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, et al.
PLoS genetics (2017) 133: e1006684. 135 303 IHC

Modifications of perineuronal nets and remodelling of excitatory and inhibitory afferents during vestibular compensation in the adult mouse.
Faralli A, Dagna F, Albera A, Bekku Y, Oohashi T, Albera R, Rossi F, Carulli D
Brain structure & function (2016) 2216: 3193-209. 135 303 IHC

Large-scale reconstitution of a retina-to-brain pathway in adult rats using gene therapy and bridging grafts: An anatomical and behavioral analysis.
You SW, Hellström M, Pollett MA, LeVaillant C, Moses C, Rigby PJ, Penrose M, Rodger J, Harvey AR
Experimental neurology (2016) 279: 197-211. 135 303 IHC

Myelin Basic Protein Cleaves Cell Adhesion Molecule L1 and Improves Regeneration After Injury.
Lutz D, Kataria H, Kleene R, Loers G, Chaudhary H, Guseva D, Wu B, Jakovcevski I, Schachner M
Molecular neurobiology (2016) 535: 3360-3376. 135 303 IHC

Somatosensory brainstem, thalamus, and cortex of the California sea lion (Zalophus californianus).
Sawyer EK, Turner EC, Kaas JH
The Journal of comparative neurology (2016) 5249: 1957-75. 135 303 IHC

A critical period for postnatal adaptive plasticity in a model of motor axon miswiring.
Helmbrecht MS, Soellner H, Castiblanco-Urbina MA, Winzeck S, Sundermeier J, Theis FJ, Fouad K, Huber AB
PloS one (2015) 104: e0123643. 135 303 IHC

Conserved expression of the GPR151 receptor in habenular axonal projections of vertebrates.
Broms J, Antolin-Fontes B, Tingström A, Ibañez-Tallon I
The Journal of comparative neurology (2015) 5233: 359-80. 135 303 IHC

Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy.
Miller N, Feng Z, Edens BM, Yang B, Shi H, Sze CC, Hong BT, Su SC, Cantu JA, Topczewski J, Crawford TO, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3515: 6038-50. 135 303 IHC

Neuronal BDNF signaling is necessary for the effects of treadmill exercise on synaptic stripping of axotomized motoneurons.
Krakowiak J, Liu C, Papudesu C, Ward PJ, Wilhelm JC, English AW
Neural plasticity (2015) 2015: 392591. 135 303 IHC

Nuclei-specific differences in nerve terminal distribution, morphology, and development in mouse visual thalamus.
Hammer S, Carrillo GL, Govindaiah G, Monavarfeshani A, Bircher JS, Su J, Guido W, Fox MA
Neural development (2014) 9: 16. 135 303 IHC

Normal distribution of VGLUT1 synapses on spinal motoneuron dendrites and their reorganization after nerve injury.
Rotterman TM, Nardelli P, Cope TC, Alvarez FJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3410: 3475-92. 135 303 IHC; tested species: rat

Localization of diacylglycerol lipase alpha and monoacylglycerol lipase during postnatal development of the rat retina.
Cécyre B, Monette M, Beudjekian L, Casanova C, Bouchard JF
Frontiers in neuroanatomy (2014) 8: 150. 135 303 IHC; tested species: rat

Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease.
Šišková Z, Reynolds RA, O'Connor V, Perry VH
PloS one (2013) 81: e55004. 135 303 IHC; tested species: mouse

Somatosensory projections to cochlear nucleus are upregulated after unilateral deafness.
Zeng C, Yang Z, Shreve L, Bledsoe S, Shore S
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3245: 15791-801. 135 303 IHC

Loss of cortical GABA terminals in Unverricht-Lundborg disease.
Buzzi A, Chikhladze M, Falcicchia C, Paradiso B, Lanza G, Soukupova M, Marti M, Morari M, Franceschetti S, Simonato M
Neurobiology of disease (2012) 472: 216-24. 135 303 IHC; tested species: mouse

NMDA receptors in GABAergic synapses during postnatal development.
Cserép C, Szabadits E, Szőnyi A, Watanabe M, Freund TF, Nyiri G
PloS one (2012) 75: e37753. 135 303 IHC, EM; tested species: mouse

Age-related changes of glycine receptor at the rat hippocampus: from the embryo to the adult.
Aroeira RI, Ribeiro JA, Sebastião AM, Valente CA
Journal of neurochemistry (2011) 1183: 339-53. 135 303 IHC; tested species: rat

Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.
Cao P, Maximov A, Südhof TC
Cell (2011) 1452: 300-11. 135 303 ICC, IHC; tested species: mouse

Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complex.
Fortune T, Lurie DI
The Journal of comparative neurology (2009) 5135: 542-58. 135 303 IHC; tested species: mouse

Ongoing epileptiform activity in the post-ischemic hippocampus is associated with a permanent shift of the excitatory-inhibitory synaptic balance in CA3 pyramidal neurons.
Epsztein J, Milh M, Bihi RI, Jorquera I, Ben-Ari Y, Represa A, Crépel V
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2626: 7082-92. 135 303 IHC; tested species: rat

Mammalian motor neurons corelease glutamate and acetylcholine at central synapses.
Nishimaru H, Restrepo CE, Ryge J, Yanagawa Y, Kiehn O
Proceedings of the National Academy of Sciences of the United States of America (2005) 10214: 5245-9. 135 303 IHC; tested species: mouse

3D Imaging of Axons in Transparent Spinal Cords from Rodents and Nonhuman Primates,.
Soderblom C, Lee DH, Dawood A, Carballosa M, Jimena Santamaria A, Benavides FD, Jergova S, Grumbles RM, Thomas CK, Park KK, Guest JD, et al.
eNeuro () 22: . 135 303 IHC

A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum.
Farini D, Cesari E, Weatheritt RJ, La Sala G, Naro C, Pagliarini V, Bonvissuto D, Medici V, Guerra M, Di Pietro C, Rizzo FR, et al.
Cell reports (2020) 319: 107703. 135 303 IHC-P; tested species: mouse

Transmitter inputs to different motoneuron subgroups in the oculomotor and trochlear nucleus in monkey.
Zeeh C, Mustari MJ, Hess BJ, Horn AK
Frontiers in neuroanatomy (2015) 9: 95. 135 303 IHC-P

Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions.
Bormuth I, Yan K, Yonemasu T, Gummert M, Zhang M, Wichert S, Grishina O, Pieper A, Zhang W, Goebbels S, Tarabykin V, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 332: 641-51. 135 303 IHC-P; tested species: mouse

Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum.
Hirasawa M, Xu X, Trask RB, Maddatu TP, Johnson BA, Naggert JK, Nishina PM, Ikeda A
Molecular and cellular neurosciences (2007) 351: 161-70. 135 303 IHC-P; tested species: mouse

Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells.
Ciarpella F, Zamfir RG, Campanelli A, Pedrotti G, Di Chio M, Bottani E, Decimo I
STAR protocols (2023) 43: 102413. 135 303 IHC-Fr; tested species: mouse

Protecting RNA quality for spatial transcriptomics while improving immunofluorescent staining quality.
Hahn N, Bens M, Kempfer M, Reißig C, Schmidl L, Geis C
Frontiers in neuroscience (2023) 17: 1198154. 135 303 IHC-Fr; tested species: mouse

Spatial proteomics in neurons at single-protein resolution.
Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, et al.
Cell (2024) 1877: 1785-1800.e16. 135 303 DNA-PAINT; tested species: rat

Aging alters mechanisms underlying voluntary movements in spinal motor neurons of mice, primates, and humans.
Castro RW, Lopes MC, Settlage RE, Valdez G
JCI insight (2023) 89: . 135 303 Clarity; tested species: human,mouse,monkey

Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter.
Bentea E, Villers A, Moore C, Funk AJ, O'Donovan SM, Verbruggen L, Lara O, Janssen P, De Pauw L, Declerck NB, DePasquale EAK, et al.
Molecular psychiatry (2020) : . 135 303 EM; tested species: mouse

Inhibitory and excitatory axon terminals share a common nano-architecture of their Cav2.1 (P/Q-type) Ca(2+) channels.
Althof D, Baehrens D, Watanabe M, Suzuki N, Fakler B, Kulik Á
Frontiers in cellular neuroscience (2015) 9: 315. 135 303 EM

Effects of subthalamic nucleus lesions and stimulation upon corticostriatal afferents in the 6-hydroxydopamine-lesioned rat.
Walker RH, Moore C, Davies G, Dirling LB, Koch RJ, Meshul CK
PloS one (2012) 73: e32919. 135 303 EM; tested species: rat

Deletion of p75NTR rescues the synaptic but not the inflammatory status in the brain of a mouse model for Alzheimer's disease.
Demuth H, Hosseini S, Düsedeau HP, Dunay IR, Korte M, Zagrebelsky M
Frontiers in molecular neuroscience (2023) 16: 1163087. 135 303 FACS; tested species: mouse

Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.
Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3411: 3826-40. 135 303 IHC-Fr; tested species: mouse

Cat. No.: 135 303

Amount: 50 µg

Price: $465.00

Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses.
Song SH, Augustine GJ
Cell reports (2023) 428: 113004. 135 303 ICC; tested species: mouse

Neuronal activity controls transsynaptic geometry.
Glebov OO, Cox S, Humphreys L, Burrone J
Scientific reports (2016) 6: 22703. 135 303 ICC

Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors.
Andreae LC, Burrone J
Cell reports (2015) : . 135 303 ICC

Neuronal synapse formation induced by microglia and interleukin 10.
Lim SH, Park E, You B, Jung Y, Park AR, Park SG, Lee JR
PloS one (2013) 811: e81218. 135 303 ICC

Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.
Cao P, Maximov A, Südhof TC
Cell (2011) 1452: 300-11. 135 303 ICC, IHC; tested species: mouse

Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory Synapse.
Chen C, Arai I, Satterfield R, Young SM, Jonas P
Cell reports (2017) 183: 723-736. 135 303 IHC

Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.
Cao P, Maximov A, Südhof TC
Cell (2011) 1452: 300-11. 135 303 ICC, IHC; tested species: mouse

Transmitter inputs to different motoneuron subgroups in the oculomotor and trochlear nucleus in monkey.
Zeeh C, Mustari MJ, Hess BJ, Horn AK
Frontiers in neuroanatomy (2015) 9: 95. 135 303 IHC-P

ICC

IHC

IHC-P

Background

The vesicular glutamate transporter 1 VGLUT 1, also referred to as BNPI and SLC17A7, was originally identified as a brain specific phosphate transporter. Like the related VGLUT 2, VGLUT 1 is both necessary and sufficient for uptake and storage of glutamate and thus comprises the sole determinant for a glutamatergic phenotype. Both VGLUTs are different from the plasma membrane transporters in that they are driven by a proton electrochemical gradient across the vesicle membrane.
VGLUT 1 and VGLUT 2 show complementary expression patterns. Together, they are currently the best markers for glutamatergic nerve terminals and glutamatergic synapses.

1 ) Takamori S, Nature (2000) 4076801: 189-94.
2 ) Bellocchio EE, Science (New York, N.Y.) (2000) 2895481: 957-60.
3 ) Bellocchio EE, The Journal of neuroscience : the official journal of the Society for Neuroscience (1998) 1821: 8648-59.
4 ) Ni B, Proceedings of the National Academy of Sciences of the United States of America (1994) 9112: 5607-11.

Protocols

Standard protocol

ICC

IHC

IHC-P

IHC-Fr

ELISA

Membrane proteins

OTHER

Preabsorbtion

Other products for this target

VGLUT1 antibody - 135 303 K.O.

References for VGLUT1 - 135 303