Cat. No.: HS-375 017
Amount: 100 µg
Price:
$415.00
|
|
|
| Cat. No. HS-375 017 |
100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | SY-322C12 |
| Subtype | IgG2b (κ light chain) |
| Immunogen | synthetic peptide corresponding to residues surrounding AA 847 of mouse CD11c (UniProt Id: Q9QXH4) |
| Reactivity |
Reacts with: mouse (Q9QXH4). No signal: rat (D3ZWZ1), human (P20702). Other species not tested yet. |
| Specificity | Specific for mouse CD11c without cross-reactivity to human CD11c |
| Remarks |
IHC: Heat-mediated antigen retrieval (in citrate buffer pH 6) is required for immunohistochemical staining. |
| Data sheet | hs-375_017.pdf |
Important information|
|
CD11c or Integrin alpha-X (ITGAX) is a heterodimeric glycoprotein consisting of an α- and β-subunit and has seven repeating integrin domains. This transmembrane receptor type I plays a pivotal role in T cell killing and mediates intercellular adhesions during inflammation. Predominat expression levels have been found in dendritic cells, monocytes, macrophages, neutrophils and a small subset of B cells. Under pathological conditions, CD11c is a marker for hairy cell leukemia, acute non-lymphocytic leukemias, and some chronic lymphocytic leukemias.