Cat. No.: 527 005
Amount: 50 µg
Price:
$465.00
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| Cat. No. 527 005 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to residues near the carboxy terminus of mouse von Willebrand factor (UniProt Id: Q8CIZ8) |
| Reactivity |
Reacts with: mouse (Q8CIZ8), rat (A0A8J8XVZ5). Other species not tested yet. |
| Specificity | Does not recognize von Willebrand antigen 2 |
| Remarks |
WB: Cat. no. 527 015 is recommended for this application. |
| Data sheet | 527_005.pdf |
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von Willebrand factor (vWF) is a key glycoprotein primarily expressed in endothelial cells and stored in Weibel-Palade bodies, playing a vital role in hemostasis and vascular biology (1). It is also present in platelets and the subendothelial matrix, contributing to thrombosis and inflammation (2). vWF expression is heterogeneous in different tissues, for example, in the kidney, its expression varies among glomerular endothelial cells, affecting susceptibility to complement-mediated injury in atypical hemolytic uremic syndrome (aHUS) (2). In the brain, vWF is abundant in endothelial cells and contributes to blood-brain barrier regulation, affecting permeability under hypoxia and seizures (3). Disease associations include von Willebrand disease (vWD), thrombotic thrombocytopenic purpura (TTP), and cardiovascular disorders. In vWD, impaired vWF leads to bleeding tendencies, while excessive vWF activity in TTP causes microvascular thrombosis (2). Additionally, vWF modulates angiogenesis by regulating endothelial cell proliferation and migration (1).