Cat. No.: 526 008
Amount: 50 µg
Price:
$420.00
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| Cat. No. 526 008 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Rb557B6 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Protein complex consisting of L1CAM cross-linked with a monoclonal antibody to the L2/HNK-1 carbohydrate epitope and KLH (UniProt Id: P11627) |
| Reactivity |
Reacts with: mouse (P11627). No signal: rat. Other species not tested yet. |
| Remarks |
This antibody is a chimeric antibody based on the monoclonal rat antibody 557B6. The constant regions of the heavy and light chains have been replaced with rabbit specific sequences. The antibody can therefore be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 526_008.pdf |
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The Neural Cell Adhesion Molecule L1 (NCAM-L1), also known as L1CAM or CD171, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Structurally, L1CAM comprises six immunoglobulin-like domains followed by five fibronectin type III domains in its extracellular region, a single transmembrane segment, and a short cytoplasmic tail (1, 2).
L1CAM is predominantly expressed on the surface of neurons mediating neuron-neuron adhesion and neurite outgrowth (3). It is also found in non-neuronal cells such as immature oligodendrocytes, Schwann cells, and certain immune cells like T cells (4, 5). Moreover, L1CAM expression has been observed in a variety of tumors across different organ systems (6).
Mutations or dysregulation of L1CAM are associated with several neurological disorders collectively termed L1 syndrome. These comprise X-linked hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait, and adducted thumbs), and spastic paraplegia type 1 (7).