Cat. No.: 485 005
Amount: 50 µg
Price:
$455.00
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| Cat. No. 485 005 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of human FoxP2. (UniProt Id: O15409) |
| Reactivity |
Reacts with: mouse (P58463), rat (P0CF24). Other species not tested yet. |
| Remarks |
IHC: For IHC on rat tissue, the FoxP2 antiserum 485 004 is recommended. |
| Data sheet | 485_005.pdf |
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Forkhead box protein P2, FoxP2 is a transcription factor protein that belongs to the family of winged-helix DNA binding proteins known as the Fox family (1). The FoxP subclass comprises four members, FoxP1-4 (2). FoxP3 is mainly expressed in the immune system, while FoxP1, 2 and 4 occur in various tissues (2). In brain they are located to distinct cell types in a specific spatiotemporal pattern (2, 3). FoxP2 is involved in a wide range of biological processes, including neuronal and lung development (1). Mutations in the FOXP2 gene have been implicated in several human speech and language disorders (4). Consistent with these findings, FoxP2 was shown to play an important role in the transcriptional control of the SRXP2 gene that regulates synapse formation and vocalization in mice (5).