Cat. No.: 469 003
Amount: 100 µl
Price:
$375.00
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| Cat. No. 469 003 |
100 µl specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Rat FAAH 1 recombinant protein lacking the amino terminal transmembrane domain. (UniProt Id: O08914) |
| Reactivity |
Reacts with: mouse (O08914), rat (P97612). Other species not tested yet. |
| Specificity | K.O. validated PubMed: 35986066 |
| Data sheet | 469_003.pdf |
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N-acyl amino acids are a group of bioactive lipids with transmitter function (1) that consist of a fatty acid tail conjugated to an amino acid head group (amidated lipids or fatty acid amides). Fatty-acid amide hydrolase 1 (FAAH 1) is an ER associated transmembrane protein (2) that catalyzes the hydrolysis and thereby inactivation of different endogenous amidated lipids to their corresponding fatty acids. Prominent examples are the appetite stimulating endocannabinoid anandamide (3) as well as oleamid, a fatty acid amide involved in sleep regulation (4). Intracellular, membrane located FAAH1 and the extracellular N-acyl amino acid synthase/hydrolase PM20D1 cooperate in the hydrolysis of amino acid-conjugated fatty acids and show overlapping but distinct substrate specificity (2).