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Opalin antibody - 457 011

Opalin is a specific marker for myelinating oligodendrocytes
Mouse monoclonal purified IgG
Cat. No.: 457 011
Amount: 100 µg
Price: $415.00
Cat. No. 457 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP-staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 up to 1 : 2000 gallery  
Clone SY-301H8E4
Subtype IgG2a (κ light chain)
Immunogen Recombinant protein corresponding to AA 52 to 143 from mouse Opalin (UniProt Id: Q7M750)
Reactivity Reacts with: mouse (Q7M750), rat (Q56A26), human (Q96PE5).
Other species not tested yet.
Data sheet 457_011.pdf
Cat. No.: 457 011
Amount: 100 µg
Price: $415.00
Background

Opalin also called Tmem10 is a transmembrane protein detected specifically in mammalian oligodendrocytes. Opalin homologs are found only in mammals and not in the genome sequences of other animal classes (1). Deficient mice are born the expected Mendelian ratio and have a normal body shape and weight. No obvious abnormalities in gross anatomy or major myelin protein components nor in the compartment of myelinated axons and oligodendrocyte maturation. Nevertheless, deficient mice display increased exploratory activity in a novel environment (2).