Cat. No.: 447 005
Amount: 50 µg
Price:
$460.00
|
|
|
| Cat. No. 447 005 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 264 to 521 from mouse Occludin (UniProt Id: Q61146) |
| Reactivity |
Reacts with: mouse (Q61146), rat (Q6P6T5), dog (Q28269). Other species not tested yet. |
| Remarks |
ICC: Methanol fixation is recommended |
| Data sheet | 447_005.pdf |
|
|
Occludin, a 65-kDa tetraspan integral membrane protein, plays a role in the formation and regulation of the tight junction paracellular permeability barrier. The C-terminal is cytoplasmic and is important for interaction with ZO-1, which links the protein complex to the actin cytoskeleton. Occludin is localized at tight junctions of both epithelial and endothelial cells. (1) It is highly expressed in the testis, kidney, lung, liver and brain. Expression of occludin is required for the infection of liver cells by the hepatitis C virus (HCV). (2)