Cat. No.: 431 002
Amount: 200 µl
Price:
$355.00
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| Cat. No. 431 002 |
200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: not tested yet IHC: 1 : 500 gallery IHC-P: not tested yet |
| Immunogen | Recombinant protein corresponding to AA 410 to 487 from human Prosaposin (UniProt Id: P07602) |
| Reactivity |
Reacts with: mouse (Q61207), human (P07602). Other species not tested yet. |
| Specificity | recognizes Saposin-D and Prosaposin |
| Data sheet | 431_002.pdf |
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The glycoprotein prosaposin is a precursor oft the sphingolipid activator proteins saposins A, B, C, and D also called (SAP-A, SAP-B, SAP-C and SAP-D). Prosaposin is targeted to lysosomes where it is proteolytically processed to the final SAP products.
Saposins are indispensable for lysosomal hydrolysis of sphingolipids and the lack of each saposin leads to a lysosomal storage disease. Sap-D-deficient mice accumulate ceramides with hydroxylated fatty acids mainly in brain and kidney.