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MDGA1 antibody - 421 002 K.O.

MDGA1 is an IgSF protein involved in neural development
Rabbit polyclonal antiserum
Cat. No.: 421 002
Amount: 200 µl
Price: $360.00
Cat. No. 421 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P: not tested yet

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen Recombinant protein corresponding to AA 19 to 917 from mouse MDGA1 (UniProt Id: Q0PMG2)
Reactivity Reacts with: mouse (Q0PMG2).
Other species not tested yet.
Specificity K.O. validated PubMed: 35532105
Data sheet 421_002.pdf

References for MDGA1 - 421 002

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 421 002 WB, IHC-Fr; KO verified; tested species: mouse
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula.
Wang X, Wei H, Hu Z, Jiang J, Dong X, Zhu J, Chen H, Brose N, Lipstein N, Xu T, Connor SA, et al.
Theranostics (2025) 155: 1842-1863. 421 002 WB, IHC; KO verified; tested species: mouse
Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.
Blumenreich S, Ben-Yashar DP, Shalit T, Kupervaser M, Milenkovic I, Joseph T, Futerman AH
Journal of neurochemistry (2024) 1681: 52-65. 421 002 WB, IHC; KD verified; tested species: rat
Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn.
Li HL, Guo RJ, Ai ZR, Han S, Guan Y, Li JF, Wang Y
Neurochemical research (2024) 492: 507-518. 421 002 WB, IHC; tested species: rat
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula.
Wang X, Wei H, Hu Z, Jiang J, Dong X, Zhu J, Chen H, Brose N, Lipstein N, Xu T, Connor SA, et al.
Theranostics (2025) 155: 1842-1863. 421 002 WB, IHC; KO verified; tested species: mouse
Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.
Blumenreich S, Ben-Yashar DP, Shalit T, Kupervaser M, Milenkovic I, Joseph T, Futerman AH
Journal of neurochemistry (2024) 1681: 52-65. 421 002 WB, IHC; KD verified; tested species: rat
Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn.
Li HL, Guo RJ, Ai ZR, Han S, Guan Y, Li JF, Wang Y
Neurochemical research (2024) 492: 507-518. 421 002 WB, IHC; tested species: rat
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 421 002 WB, IHC-Fr; KO verified; tested species: mouse
Cat. No.: 421 002
Amount: 200 µl
Price: $360.00
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 421 002 WB, IHC-Fr; KO verified; tested species: mouse
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula.
Wang X, Wei H, Hu Z, Jiang J, Dong X, Zhu J, Chen H, Brose N, Lipstein N, Xu T, Connor SA, et al.
Theranostics (2025) 155: 1842-1863. 421 002 WB, IHC; KO verified; tested species: mouse
Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.
Blumenreich S, Ben-Yashar DP, Shalit T, Kupervaser M, Milenkovic I, Joseph T, Futerman AH
Journal of neurochemistry (2024) 1681: 52-65. 421 002 WB, IHC; KD verified; tested species: rat
Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn.
Li HL, Guo RJ, Ai ZR, Han S, Guan Y, Li JF, Wang Y
Neurochemical research (2024) 492: 507-518. 421 002 WB, IHC; tested species: rat
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula.
Wang X, Wei H, Hu Z, Jiang J, Dong X, Zhu J, Chen H, Brose N, Lipstein N, Xu T, Connor SA, et al.
Theranostics (2025) 155: 1842-1863. 421 002 WB, IHC; KO verified; tested species: mouse
Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.
Blumenreich S, Ben-Yashar DP, Shalit T, Kupervaser M, Milenkovic I, Joseph T, Futerman AH
Journal of neurochemistry (2024) 1681: 52-65. 421 002 WB, IHC; KD verified; tested species: rat
Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn.
Li HL, Guo RJ, Ai ZR, Han S, Guan Y, Li JF, Wang Y
Neurochemical research (2024) 492: 507-518. 421 002 WB, IHC; tested species: rat
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 421 002 WB, IHC-Fr; KO verified; tested species: mouse
IHC
IHC
IHC
IHC
IHC
Background

MAM domain GPI anchor 1 and 2 proteins (MDGA1 and MDGA2) are Ig superfamily adhesion molecules composed of six IG domains, a fibronectin III domain, a MAM domain, and a GPI anchor.

MDGAs are required for radial migration and positioning of cortical neurons making it a useful layer and area specific marker during neural development.

They play a role in the formation or maintenance of Neuroligin2 positive inhibitory synapses.