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Brn3a antibody - 411 003

Brn3a is a transcription factor involved in neuronal development
Rabbit polyclonal purified antibody
Cat. No.: 411 003
Amount: 50 µg
Price: $380.00
Cat. No. 411 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 1000 up to 1 : 5000 (see remarks) gallery  
IHC-P: 1 : 500 up to 1 : 1000 gallery  
Immunogen Synthetic peptide corresponding to residues near the amino terminus of mouse Brn3a (UniProt Id: P17208)
Reactivity Reacts with: mouse (P17208).
Other species not tested yet.
Remarks

IHC: For optimal results, mild fixation (immersion fixation with 4% PFA for 15 min) according to Gierke et al. 2023 is recommended.
Data sheet 411_003.pdf

References for Brn3a - 411 003

Resveratrol attenuates retinal ganglion cell loss in a mouse model of retinal ischemia reperfusion injury via multiple pathways.
Ji K, Li Z, Lei Y, Xu W, Ouyang L, He T, Xing Y
Experimental eye research (2021) 209: 108683. 411 003 WB, IHC; tested species: mouse
Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors.
Schoepf CL, Zeidler M, Spiecker L, Kern G, Lechner J, Kummer KK, Kress M
Brain sciences (2020) 106: . 411 003 ICC; tested species: human,mouse
Transcriptional responses in a mouse model of silicone wire embolization induced acute retinal artery ischemia and reperfusion.
Wang Y, Li Y, Feng J, Wang C, Wan Y, Lv B, Li Y, Xie H, Chen T, Wang F, Li Z, et al.
eLife (2024) 13: . 411 003 IHC; tested species: mouse
Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact.
Kwok A, Chaqour B, Khan RS, Aravand P, Dine K, Ross AG, Shindler KS
Translational vision science & technology (2024) 139: 27. 411 003 IHC; tested species: mouse
Comparison of SNCG and NEFH Promoter-Driven Expression of Human SIRT1 Expression in a Mouse Model of Glaucoma.
O'Neill N, Meng M, Chaqour B, Dine K, Sarabu N, Pham JC, Shindler KS, Ross AG
Translational vision science & technology (2024) 138: 37. 411 003 IHC; tested species: mouse
A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity.
Clayton BLL, Kristell JD, Allan KC, Cohn EF, Karl M, Jerome AD, Garrison E, Maeno-Hikichi Y, Sturno AM, Kerr A, Shick HE, et al.
Nature neuroscience (2024) 274: 656-665. 411 003 IHC; tested species: mouse
Ameliorative effect of resveratrol on acute ocular hypertension induced retinal injury through the SIRT1/NF-κB pathway.
Ji KB, Wan W, Yang Y, He XJ, Xing YQ, Hu Z
Neuroscience letters (2024) 826: 137712. 411 003 IHC; tested species: mouse
Optimizing retinal ganglion cell nuclear staining for automated cell counting.
Lin F, Lin ST, Wang J, Geisert EE
Experimental eye research (2024) 242: 109881. 411 003 IHC; tested species: mouse
AAV2 vector optimization for retinal ganglion cell-targeted delivery of therapeutic genes.
Chaqour B, Duong TT, Yue J, Liu T, Camacho D, Dine KE, Esteve-Rudd J, Ellis S, Bennett J, Shindler KS, Ross AG, et al.
Gene therapy (2024) 313-4: 175-186. 411 003 IHC; tested species: mouse
Resveratrol Ameliorates Retinal Ischemia-Reperfusion Injury by Modulating the NLRP3 Inflammasome and Keap1/Nrf2/HO-1 Signaling Pathway.
Feng J, Ji K, Pan Y, Huang P, He T, Xing Y
Molecular neurobiology (2024) : . 411 003 IHC; tested species: mouse
Intranasal Resveratrol Nanoparticles Enhance Neuroprotection in a Model of Multiple Sclerosis.
Shamsher E, Khan RS, Davis BM, Dine K, Luong V, Cordeiro MF, Shindler KS
International journal of molecular sciences (2024) 257: . 411 003 IHC; tested species: mouse
Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.
Meng M, Chaqour B, O'Neill N, Dine K, Sarabu N, Ying GS, Shindler KS, Ross AG
Investigative ophthalmology & visual science (2024) 654: 19. 411 003 IHC; tested species: mouse
A Non-canonical Excitatory PV RGC-PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response.
Yuan M, Jin S, Tan G, Song S, Liu Y, Wang H, Shen Y
Neuroscience bulletin (2024) 403: 310-324. 411 003 IHC; tested species: mouse
Reduction of retinal ganglion cell death in mouse models of familial dysautonomia using AAV-mediated gene therapy and splicing modulators.
Schultz A, Cheng SY, Kirchner E, Costello S, Miettinen H, Chaverra M, King C, George L, Zhao X, Narasimhan J, Weetall M, et al.
Scientific reports (2023) 131: 18600. 411 003 IHC; tested species: mouse
Optimisation of AAV-NDI1 Significantly Enhances Its Therapeutic Value for Correcting Retinal Mitochondrial Dysfunction.
Chadderton N, Palfi A, Maloney DM, Carrigan M, Finnegan LK, Hanlon KS, Shortall C, O'Reilly M, Humphries P, Cassidy L, Kenna PF, et al.
Pharmaceutics (2023) 152: . 411 003 IHC; tested species: mouse
Inhibition of Heat Shock Protein B8 Alleviates Retinal Dysfunction and Ganglion Cells Loss Via Autophagy Suppression in Mouse Axonal Damage.
Xie F, Li Z, Yang N, Yang J, Hua D, Luo J, He T, Xing Y
Investigative ophthalmology & visual science (2022) 636: 28. 411 003 IHC; tested species: mouse
SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration.
Finnegan LK, Chadderton N, Kenna PF, Palfi A, Carty M, Bowie AG, Millington-Ward S, Farrar GJ
International journal of molecular sciences (2022) 233: . 411 003 IHC; tested species: mouse
Therapeutic Potential of a Novel Glucagon-like Peptide-1 Receptor Agonist, NLY01, in Experimental Autoimmune Encephalomyelitis.
Gharagozloo M, Smith MD, Sotirchos ES, Jin J, Meyers K, Taylor M, Garton T, Bannon R, Lord HN, Dawson TM, Dawson VL, et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2021) 183: 1834-1848. 411 003 IHC; tested species: mouse
Resveratrol attenuates retinal ganglion cell loss in a mouse model of retinal ischemia reperfusion injury via multiple pathways.
Ji K, Li Z, Lei Y, Xu W, Ouyang L, He T, Xing Y
Experimental eye research (2021) 209: 108683. 411 003 WB, IHC; tested species: mouse
Krüppel-like factor 7 protects retinal ganglion cells and promotes functional preservation via activating the Akt pathway after retinal ischemia-reperfusion injury.
Li Z, Xie F, Yang N, Yang J, Luo J, Hua D, He T, Xing Y
Experimental eye research (2021) 207: 108587. 411 003 IHC; tested species: mouse
Neuroprotection mediated by ST266 requires full complement of proteins secreted by amnion-derived multipotent progenitor cells.
Willett K, Khan RS, Dine K, Wessel H, Kirshner ZZ, Sauer JL, Ellis A, Brown LR, Shindler KS
PloS one (2021) 161: e0243862. 411 003 IHC; tested species: mouse
SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice.
Luo J, He T, Yang J, Yang N, Li Z, Xing Y
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020) 2582: 335-344. 411 003 IHC; tested species: mouse
GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension.
Sterling JK, Adetunji MO, Guttha S, Bargoud AR, Uyhazi KE, Ross AG, Dunaief JL, Cui QN
Cell reports (2020) 335: 108271. 411 003 IHC; tested species: mouse
Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo.
Niu X, Liu L, Wang T, Chuan X, Yu Q, Du M, Gu Y, Wang L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4035: 6691-6708. 411 003 IHC; tested species: mouse
Amnion-Derived Multipotent Progenitor Cells Suppress Experimental Optic Neuritis and Myelitis.
Khan RS, Ross AG, Willett K, Dine K, Banas R, Brown LR, Shindler KS
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2020) : . 411 003 IHC; tested species: mouse
One proline deletion in the fusion peptide of neurotropic mouse hepatitis virus (MHV) restricts retrograde axonal transport and neurodegeneration.
Rout SS, Singh M, Shindler KS, Das Sarma J
The Journal of biological chemistry (2020) 29520: 6926-6935. 411 003 IHC; tested species: mouse
Oral administration of the iron chelator deferiprone protects against loss of retinal ganglion cells in a mouse model of glaucoma.
Cui QN, Bargoud AR, Ross AG, Song Y, Dunaief JL
Experimental eye research (2020) : 107961. 411 003 IHC; tested species: mouse
Cat. No.: 411 003
Amount: 50 µg
Price: $380.00
Resveratrol attenuates retinal ganglion cell loss in a mouse model of retinal ischemia reperfusion injury via multiple pathways.
Ji K, Li Z, Lei Y, Xu W, Ouyang L, He T, Xing Y
Experimental eye research (2021) 209: 108683. 411 003 WB, IHC; tested species: mouse
Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors.
Schoepf CL, Zeidler M, Spiecker L, Kern G, Lechner J, Kummer KK, Kress M
Brain sciences (2020) 106: . 411 003 ICC; tested species: human,mouse
Transcriptional responses in a mouse model of silicone wire embolization induced acute retinal artery ischemia and reperfusion.
Wang Y, Li Y, Feng J, Wang C, Wan Y, Lv B, Li Y, Xie H, Chen T, Wang F, Li Z, et al.
eLife (2024) 13: . 411 003 IHC; tested species: mouse
Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact.
Kwok A, Chaqour B, Khan RS, Aravand P, Dine K, Ross AG, Shindler KS
Translational vision science & technology (2024) 139: 27. 411 003 IHC; tested species: mouse
Comparison of SNCG and NEFH Promoter-Driven Expression of Human SIRT1 Expression in a Mouse Model of Glaucoma.
O'Neill N, Meng M, Chaqour B, Dine K, Sarabu N, Pham JC, Shindler KS, Ross AG
Translational vision science & technology (2024) 138: 37. 411 003 IHC; tested species: mouse
A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity.
Clayton BLL, Kristell JD, Allan KC, Cohn EF, Karl M, Jerome AD, Garrison E, Maeno-Hikichi Y, Sturno AM, Kerr A, Shick HE, et al.
Nature neuroscience (2024) 274: 656-665. 411 003 IHC; tested species: mouse
Ameliorative effect of resveratrol on acute ocular hypertension induced retinal injury through the SIRT1/NF-κB pathway.
Ji KB, Wan W, Yang Y, He XJ, Xing YQ, Hu Z
Neuroscience letters (2024) 826: 137712. 411 003 IHC; tested species: mouse
Optimizing retinal ganglion cell nuclear staining for automated cell counting.
Lin F, Lin ST, Wang J, Geisert EE
Experimental eye research (2024) 242: 109881. 411 003 IHC; tested species: mouse
AAV2 vector optimization for retinal ganglion cell-targeted delivery of therapeutic genes.
Chaqour B, Duong TT, Yue J, Liu T, Camacho D, Dine KE, Esteve-Rudd J, Ellis S, Bennett J, Shindler KS, Ross AG, et al.
Gene therapy (2024) 313-4: 175-186. 411 003 IHC; tested species: mouse
Resveratrol Ameliorates Retinal Ischemia-Reperfusion Injury by Modulating the NLRP3 Inflammasome and Keap1/Nrf2/HO-1 Signaling Pathway.
Feng J, Ji K, Pan Y, Huang P, He T, Xing Y
Molecular neurobiology (2024) : . 411 003 IHC; tested species: mouse
Intranasal Resveratrol Nanoparticles Enhance Neuroprotection in a Model of Multiple Sclerosis.
Shamsher E, Khan RS, Davis BM, Dine K, Luong V, Cordeiro MF, Shindler KS
International journal of molecular sciences (2024) 257: . 411 003 IHC; tested species: mouse
Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.
Meng M, Chaqour B, O'Neill N, Dine K, Sarabu N, Ying GS, Shindler KS, Ross AG
Investigative ophthalmology & visual science (2024) 654: 19. 411 003 IHC; tested species: mouse
A Non-canonical Excitatory PV RGC-PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response.
Yuan M, Jin S, Tan G, Song S, Liu Y, Wang H, Shen Y
Neuroscience bulletin (2024) 403: 310-324. 411 003 IHC; tested species: mouse
Reduction of retinal ganglion cell death in mouse models of familial dysautonomia using AAV-mediated gene therapy and splicing modulators.
Schultz A, Cheng SY, Kirchner E, Costello S, Miettinen H, Chaverra M, King C, George L, Zhao X, Narasimhan J, Weetall M, et al.
Scientific reports (2023) 131: 18600. 411 003 IHC; tested species: mouse
Optimisation of AAV-NDI1 Significantly Enhances Its Therapeutic Value for Correcting Retinal Mitochondrial Dysfunction.
Chadderton N, Palfi A, Maloney DM, Carrigan M, Finnegan LK, Hanlon KS, Shortall C, O'Reilly M, Humphries P, Cassidy L, Kenna PF, et al.
Pharmaceutics (2023) 152: . 411 003 IHC; tested species: mouse
Inhibition of Heat Shock Protein B8 Alleviates Retinal Dysfunction and Ganglion Cells Loss Via Autophagy Suppression in Mouse Axonal Damage.
Xie F, Li Z, Yang N, Yang J, Hua D, Luo J, He T, Xing Y
Investigative ophthalmology & visual science (2022) 636: 28. 411 003 IHC; tested species: mouse
SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration.
Finnegan LK, Chadderton N, Kenna PF, Palfi A, Carty M, Bowie AG, Millington-Ward S, Farrar GJ
International journal of molecular sciences (2022) 233: . 411 003 IHC; tested species: mouse
Therapeutic Potential of a Novel Glucagon-like Peptide-1 Receptor Agonist, NLY01, in Experimental Autoimmune Encephalomyelitis.
Gharagozloo M, Smith MD, Sotirchos ES, Jin J, Meyers K, Taylor M, Garton T, Bannon R, Lord HN, Dawson TM, Dawson VL, et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2021) 183: 1834-1848. 411 003 IHC; tested species: mouse
Resveratrol attenuates retinal ganglion cell loss in a mouse model of retinal ischemia reperfusion injury via multiple pathways.
Ji K, Li Z, Lei Y, Xu W, Ouyang L, He T, Xing Y
Experimental eye research (2021) 209: 108683. 411 003 WB, IHC; tested species: mouse
Krüppel-like factor 7 protects retinal ganglion cells and promotes functional preservation via activating the Akt pathway after retinal ischemia-reperfusion injury.
Li Z, Xie F, Yang N, Yang J, Luo J, Hua D, He T, Xing Y
Experimental eye research (2021) 207: 108587. 411 003 IHC; tested species: mouse
Neuroprotection mediated by ST266 requires full complement of proteins secreted by amnion-derived multipotent progenitor cells.
Willett K, Khan RS, Dine K, Wessel H, Kirshner ZZ, Sauer JL, Ellis A, Brown LR, Shindler KS
PloS one (2021) 161: e0243862. 411 003 IHC; tested species: mouse
SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice.
Luo J, He T, Yang J, Yang N, Li Z, Xing Y
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020) 2582: 335-344. 411 003 IHC; tested species: mouse
GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension.
Sterling JK, Adetunji MO, Guttha S, Bargoud AR, Uyhazi KE, Ross AG, Dunaief JL, Cui QN
Cell reports (2020) 335: 108271. 411 003 IHC; tested species: mouse
Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo.
Niu X, Liu L, Wang T, Chuan X, Yu Q, Du M, Gu Y, Wang L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4035: 6691-6708. 411 003 IHC; tested species: mouse
Amnion-Derived Multipotent Progenitor Cells Suppress Experimental Optic Neuritis and Myelitis.
Khan RS, Ross AG, Willett K, Dine K, Banas R, Brown LR, Shindler KS
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2020) : . 411 003 IHC; tested species: mouse
One proline deletion in the fusion peptide of neurotropic mouse hepatitis virus (MHV) restricts retrograde axonal transport and neurodegeneration.
Rout SS, Singh M, Shindler KS, Das Sarma J
The Journal of biological chemistry (2020) 29520: 6926-6935. 411 003 IHC; tested species: mouse
Oral administration of the iron chelator deferiprone protects against loss of retinal ganglion cells in a mouse model of glaucoma.
Cui QN, Bargoud AR, Ross AG, Song Y, Dunaief JL
Experimental eye research (2020) : 107961. 411 003 IHC; tested species: mouse
IHC
IHC
IHC-P
IHC-P
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Background

Brn 3a, also referred to as POU4F1, RGC-1 or Oct-T1, is a transcription factor highly expressed in the developing peripheral sensory nervous system, in cells of the B- and T-lymphocytic lineages and in certain regions of the CNS e.g. retina, spinal cord, midbrain superior colliculus, red nucleus, nucleus ambiguus, inferior olivary nucleus and habenula. In the retina Brn3a is a well-established marker for retinal ganglion cells.
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