Cat. No.: 391 004
Amount: 100 µl
Price:
$450.00
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| Cat. No. 391 004 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to C-terminal residues of mouse LAMP3. (UniProt Id: Q7TST5) |
| Reactivity |
Reacts with: mouse (Q7TST5), rat (Q5XI99). Other species not tested yet. |
| Specificity | Recognizes LAMP 3, no crossreactivity to LAMP 1, LAMP 2 and LAMP 5. K.O. validated |
| Remarks |
Dot blot: This application was tested with synthetic peptides only. |
| Data sheet | 391_004.pdf |
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LAMP 3 (lysosome-associated membrane glycoprotein 3), also referred to as DC-LAMP (dendritic cell LAMP) or CD 208, is a member of the LAMP protein family and a single-pass type I transmembrane protein that can be variably glycosylated. It is specifically expressed in lung type II pneumocytes and by activated human dendritic cells (1, 2).
Recent studies demonstrated high expression of LAMP 3 in a variety of malignancies including squamous cell carcinoma, gastrointestinal cancer, breast cancer, ovarian cancer, and cervical cancer. Its expression has been associated with metastasis and poor overall survival (3, 4, 5).