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Home > Products > 271 011

GalphaO2 antibody - 271 011 K.O.

GalphaO1 and 2 are G-proteins involved in the regulation of vesicular neurotransmitter transporters
Mouse monoclonal purified IgG
Cat. No.: 271 011
Amount: 100 µg
Price: $415.00
Cat. No. 271 011 100 µg purified IgG, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not recommended
IHC: not recommended
IHC-P: not tested yet
Clone 101.4
Subtype IgG2b (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 355 from rat GαO2 (UniProt Id: P18872)
Reactivity Reacts with: rat (P59215), mouse (P18872).
Other species not tested yet.
Specificity K.O. validated PubMed: 15872115
Data sheet 271_011.pdf

References for GalphaO2 - 271 011

Sex and brain region-specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice.
Haase J, Jones AKC, Mc Veigh CJ, Brown E, Clarke G, Ahnert-Hilger G
Journal of neurochemistry (2021) : . 271 011 WB; tested species: mouse
Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system.
Baron J, Bilbao A, Hörtnagl H, Birnbaumer L, Leixner S, Spanagel R, Ahnert-Hilger G, Brunk I
Journal of neurochemistry (2018) : . 271 011 WB; tested species: mouse
The α-subunit of the trimeric GTPase Go2 regulates axonal growth.
Baron J, Blex C, Rohrbeck A, Rachakonda SK, Birnbaumer L, Ahnert-Hilger G, Brunk I
Journal of neurochemistry (2013) 1246: 782-94. 271 011 WB, IP
Coordinated control of sensitivity by two splice variants of Gα(o) in retinal ON bipolar cells.
Okawa H, Pahlberg J, Rieke F, Birnbaumer L, Sampath AP
The Journal of general physiology (2010) 1364: 443-54. 271 011 WB
Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence.
Winter S, Brunk I, Walther DJ, Höltje M, Jiang M, Peter JU, Takamori S, Jahn R, Birnbaumer L, Ahnert-Hilger G
The Journal of neuroscience : the official journal of the Society for Neuroscience (2005) 2518: 4672-80. 271 011 WB; KO verified
The α-subunit of the trimeric GTPase Go2 regulates axonal growth.
Baron J, Blex C, Rohrbeck A, Rachakonda SK, Birnbaumer L, Ahnert-Hilger G, Brunk I
Journal of neurochemistry (2013) 1246: 782-94. 271 011 WB, IP
Cat. No.: 271 011
Amount: 100 µg
Price: $415.00
Sex and brain region-specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice.
Haase J, Jones AKC, Mc Veigh CJ, Brown E, Clarke G, Ahnert-Hilger G
Journal of neurochemistry (2021) : . 271 011 WB; tested species: mouse
Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system.
Baron J, Bilbao A, Hörtnagl H, Birnbaumer L, Leixner S, Spanagel R, Ahnert-Hilger G, Brunk I
Journal of neurochemistry (2018) : . 271 011 WB; tested species: mouse
The α-subunit of the trimeric GTPase Go2 regulates axonal growth.
Baron J, Blex C, Rohrbeck A, Rachakonda SK, Birnbaumer L, Ahnert-Hilger G, Brunk I
Journal of neurochemistry (2013) 1246: 782-94. 271 011 WB, IP
Coordinated control of sensitivity by two splice variants of Gα(o) in retinal ON bipolar cells.
Okawa H, Pahlberg J, Rieke F, Birnbaumer L, Sampath AP
The Journal of general physiology (2010) 1364: 443-54. 271 011 WB
Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence.
Winter S, Brunk I, Walther DJ, Höltje M, Jiang M, Peter JU, Takamori S, Jahn R, Birnbaumer L, Ahnert-Hilger G
The Journal of neuroscience : the official journal of the Society for Neuroscience (2005) 2518: 4672-80. 271 011 WB; KO verified
The α-subunit of the trimeric GTPase Go2 regulates axonal growth.
Baron J, Blex C, Rohrbeck A, Rachakonda SK, Birnbaumer L, Ahnert-Hilger G, Brunk I
Journal of neurochemistry (2013) 1246: 782-94. 271 011 WB, IP
WB
Background

Neurotransmitters like monoamines, acetylcholine, glutamate, GABA, and glycine, are loaded into synaptic vesicles by transmitter specific vesicular transporters.
It has been shown that the monoamine transporters VmaT 1 and VmaT 2 are under negative regulation by different α subunits of trimeric G-proteins.
In contrast, the vesicular glutamate transporters (VGLUTs) are exclusively regulated by GαO 2 which modulates the chloride dependence of these proteins.