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NeuN antibody - 266 006

NeuN is a neuron specific nuclear protein in vertebrates
Chicken polyclonal purified antibody
Cat. No.: 266 006
Amount: 50 µg
Price: $415.00
Cat. No. 266 006 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 100 up to 1 : 500 gallery  
IHC-P: 1 : 200 gallery  

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen Recombinant protein corresponding to AA 1 to 97 from mouse NeuN (UniProt Id: Q8BIF2)
Reactivity Reacts with: rat (D4A2H6), mouse (Q8BIF2).
Other species not tested yet.
Data sheet 266_006.pdf

References for NeuN - 266 006

Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication.
Jaudon F, Chiacchiaretta M, Albini M, Ferroni S, Benfenati F, Cesca F
Cell death and differentiation (2019) : . 266 006 ICC; tested species: mouse
Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice.
Ishchenko Y, Jeng AT, Feng S, Nottoli T, Manriquez-Rodriguez C, Nguyen KK, Carrizales MG, Vitarelli MJ, Corcoran EE, Greer CA, Myers SA, et al.
eLife (2025) 13: . 266 006 IHC; tested species: mouse
Parkinsonism disrupts cortical function by dysregulating oscillatory, network and synaptic activity of parvalbumin positive interneurons.
Minetti A, Montagni E, Meneghetti N, Macchi F, Coulomb É, Martello A, Tiberi A, Capsoni S, Mazzoni A, Allegra Mascaro AL, Spalletti C, et al.
NPJ Parkinson's disease (2025) 111: 194. 266 006 IHC; tested species: mouse
Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict.
Koga K, Kobayashi K, Tsuda M, Pickering AE, Furue H
Communications biology (2024) 71: 330. 266 006 IHC; tested species: mouse
The normalizing effects of the CYP46A1 activator efavirenz on retinal sterol levels and risk factors for glaucoma in Apoj-/- mice.
El-Darzi N, Mast N, Li Y, Dailey B, Kang M, Rhee DJ, Pikuleva IA
Cellular and molecular life sciences : CMLS (2023) 807: 194. 266 006 IHC; tested species: mouse
Region-specific heterogeneity in neuronal nuclear morphology in young, aged and in Alzheimer's disease mouse brains.
Das S, Ramanan N
Frontiers in cell and developmental biology (2023) 11: 1032504. 266 006 IHC; tested species: mouse
Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling.
Boyle KA, Polgar E, Gutierrez-Mecinas M, Dickie AC, Cooper AH, Bell AM, Jumolea E, Casas-Benito A, Watanabe M, Hughes DI, Weir GA, et al.
eLife (2023) 12: . 266 006 IHC; tested species: mouse
Transient oxygen-glucose deprivation causes region- and cell type-dependent functional deficits in the mouse hippocampus in vitro.
Grube P, Heuermann C, Rozov A, Both M, Draguhn A, Hefter D
eNeuro (2021) : . 266 006 IHC; tested species: mouse
Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT's Role in Complex Brain Disorders and Neurological Disease.
Levenga J, Wong H, Milstead R, LaPlante L, Hoeffer CA
Cerebral cortex communications (2021) 22: tgab036. 266 006 IHC; tested species: mouse
Analysis of the proportion and neuronal activity of excitatory and inhibitory neurons in the rat dorsal spinal cord after peripheral nerve injury.
Motojima Y, Ueta Y, Sakai A
Neuroscience letters (2021) 749: 135707. 266 006 IHC; tested species: rat
Substance P-expressing excitatory interneurons in the mouse superficial dorsal horn provide a propriospinal input to the lateral spinal nucleus.
Gutierrez-Mecinas M, Polgár E, Bell AM, Herau M, Todd AJ
Brain structure & function (2018) : . 266 006 IHC; tested species: mouse
Increased synthesis of chondroitin sulfate proteoglycan promotes adult hippocampal neurogenesis in response to enriched environment.
Yamada J, Nadanaka S, Kitagawa H, Takeuchi K, Jinno S
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 266 006 IHC; tested species: mouse
Structural Plasticity of Synaptopodin in the Axon Initial Segment during Visual Cortex Development.
Schlüter A, Del Turco D, Deller T, Gutzmann A, Schultz C, Engelhardt M
Cerebral cortex (New York, N.Y. : 1991) (2017) 279: 4662-4675. 266 006 IHC; tested species: mouse
Late postnatal shifts of parvalbumin and nitric oxide synthase expression within the GABAergic and glutamatergic phenotypes of inferior colliculus neurons.
Fujimoto H, Konno K, Watanabe M, Jinno S
The Journal of comparative neurology (2017) 5254: 868-884. 266 006 IHC; tested species: mouse
Widespread expression of erythropoietin receptor in brain and its induction by injury.
Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, et al.
Molecular medicine (Cambridge, Mass.) (2015) : . 266 006 IHC
Cat. No.: 266 006
Amount: 50 µg
Price: $415.00
Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication.
Jaudon F, Chiacchiaretta M, Albini M, Ferroni S, Benfenati F, Cesca F
Cell death and differentiation (2019) : . 266 006 ICC; tested species: mouse
Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice.
Ishchenko Y, Jeng AT, Feng S, Nottoli T, Manriquez-Rodriguez C, Nguyen KK, Carrizales MG, Vitarelli MJ, Corcoran EE, Greer CA, Myers SA, et al.
eLife (2025) 13: . 266 006 IHC; tested species: mouse
Parkinsonism disrupts cortical function by dysregulating oscillatory, network and synaptic activity of parvalbumin positive interneurons.
Minetti A, Montagni E, Meneghetti N, Macchi F, Coulomb É, Martello A, Tiberi A, Capsoni S, Mazzoni A, Allegra Mascaro AL, Spalletti C, et al.
NPJ Parkinson's disease (2025) 111: 194. 266 006 IHC; tested species: mouse
Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict.
Koga K, Kobayashi K, Tsuda M, Pickering AE, Furue H
Communications biology (2024) 71: 330. 266 006 IHC; tested species: mouse
The normalizing effects of the CYP46A1 activator efavirenz on retinal sterol levels and risk factors for glaucoma in Apoj-/- mice.
El-Darzi N, Mast N, Li Y, Dailey B, Kang M, Rhee DJ, Pikuleva IA
Cellular and molecular life sciences : CMLS (2023) 807: 194. 266 006 IHC; tested species: mouse
Region-specific heterogeneity in neuronal nuclear morphology in young, aged and in Alzheimer's disease mouse brains.
Das S, Ramanan N
Frontiers in cell and developmental biology (2023) 11: 1032504. 266 006 IHC; tested species: mouse
Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling.
Boyle KA, Polgar E, Gutierrez-Mecinas M, Dickie AC, Cooper AH, Bell AM, Jumolea E, Casas-Benito A, Watanabe M, Hughes DI, Weir GA, et al.
eLife (2023) 12: . 266 006 IHC; tested species: mouse
Transient oxygen-glucose deprivation causes region- and cell type-dependent functional deficits in the mouse hippocampus in vitro.
Grube P, Heuermann C, Rozov A, Both M, Draguhn A, Hefter D
eNeuro (2021) : . 266 006 IHC; tested species: mouse
Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT's Role in Complex Brain Disorders and Neurological Disease.
Levenga J, Wong H, Milstead R, LaPlante L, Hoeffer CA
Cerebral cortex communications (2021) 22: tgab036. 266 006 IHC; tested species: mouse
Analysis of the proportion and neuronal activity of excitatory and inhibitory neurons in the rat dorsal spinal cord after peripheral nerve injury.
Motojima Y, Ueta Y, Sakai A
Neuroscience letters (2021) 749: 135707. 266 006 IHC; tested species: rat
Substance P-expressing excitatory interneurons in the mouse superficial dorsal horn provide a propriospinal input to the lateral spinal nucleus.
Gutierrez-Mecinas M, Polgár E, Bell AM, Herau M, Todd AJ
Brain structure & function (2018) : . 266 006 IHC; tested species: mouse
Increased synthesis of chondroitin sulfate proteoglycan promotes adult hippocampal neurogenesis in response to enriched environment.
Yamada J, Nadanaka S, Kitagawa H, Takeuchi K, Jinno S
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 266 006 IHC; tested species: mouse
Structural Plasticity of Synaptopodin in the Axon Initial Segment during Visual Cortex Development.
Schlüter A, Del Turco D, Deller T, Gutzmann A, Schultz C, Engelhardt M
Cerebral cortex (New York, N.Y. : 1991) (2017) 279: 4662-4675. 266 006 IHC; tested species: mouse
Late postnatal shifts of parvalbumin and nitric oxide synthase expression within the GABAergic and glutamatergic phenotypes of inferior colliculus neurons.
Fujimoto H, Konno K, Watanabe M, Jinno S
The Journal of comparative neurology (2017) 5254: 868-884. 266 006 IHC; tested species: mouse
Widespread expression of erythropoietin receptor in brain and its induction by injury.
Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, et al.
Molecular medicine (Cambridge, Mass.) (2015) : . 266 006 IHC
ICC
IHC
IHC-P
Background

NeuN (Neuronal Nuclei) is a neuron-specific nuclear protein that has been identified as Fox-3/Rbfox3, a member of the Fox-1 family of transcription factors.
NeuN is only expressed in the nuclei of differentiated neurons. In some neurons - Purkinje cells, sympathetic ganglion cells, INL retinal cells, Cajal-Retzius cells, inferior olivary, and dentate nucleus neurons - NeuN is not detectable.
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