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EAAT1 antibody cytoplasmic domain - 250 114

EAATs are transmembrane proteins involved in the removal of extracellular glutamate
Guinea pig polyclonal antiserum
Cat. No.: 250 114
Amount: 100 µl
Price: $365.00
Cat. No. 250 114 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 522 to 541 from rat EAAT1 (UniProt Id: P24942)
Reactivity Reacts with: rat (P24942), mouse.
Other species not tested yet.
Matching control protein/peptide 250-11P
Data sheet 250_114.pdf

References for EAAT1 - 250 114

The expression and function of glutamate aspartate transporters in Bergmann glia are decreased in neuronal nitric oxide synthase-knockout mice during postnatal development.
Tellios V, Maksoud MJE, Lu WY
Glia (2022) : . 250 114 WB, IHC; tested species: mouse
Loss of excitatory amino acid transporter restraint following chronic intermittent hypoxia contribute to synaptic alterations in nucleus tractus solitarii.
Martinez D, Rogers RC, Hasser EM, Hermann GE, Kline DD
Journal of neurophysiology (2020) : . 250 114 WB; tested species: rat
The expression and function of glutamate aspartate transporters in Bergmann glia are decreased in neuronal nitric oxide synthase-knockout mice during postnatal development.
Tellios V, Maksoud MJE, Lu WY
Glia (2022) : . 250 114 WB, IHC; tested species: mouse
Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.
Arulkandarajah KH, Osterstock G, Lafont A, Le Corronc H, Escalas N, Corsini S, Le Bras B, Chenane L, Boeri J, Czarnecki A, Mouffle C, et al.
Current biology : CB (2021) 3120: 4584-4595.e4. 250 114 IHC; tested species: mouse
Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal Migration.
Morozov YM, Mackie K, Rakic P
International journal of molecular sciences (2020) 2122: . 250 114 IHC; tested species: mouse
Cat. No.: 250 114
Amount: 100 µl
Price: $365.00
The expression and function of glutamate aspartate transporters in Bergmann glia are decreased in neuronal nitric oxide synthase-knockout mice during postnatal development.
Tellios V, Maksoud MJE, Lu WY
Glia (2022) : . 250 114 WB, IHC; tested species: mouse
Loss of excitatory amino acid transporter restraint following chronic intermittent hypoxia contribute to synaptic alterations in nucleus tractus solitarii.
Martinez D, Rogers RC, Hasser EM, Hermann GE, Kline DD
Journal of neurophysiology (2020) : . 250 114 WB; tested species: rat
The expression and function of glutamate aspartate transporters in Bergmann glia are decreased in neuronal nitric oxide synthase-knockout mice during postnatal development.
Tellios V, Maksoud MJE, Lu WY
Glia (2022) : . 250 114 WB, IHC; tested species: mouse
Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.
Arulkandarajah KH, Osterstock G, Lafont A, Le Corronc H, Escalas N, Corsini S, Le Bras B, Chenane L, Boeri J, Czarnecki A, Mouffle C, et al.
Current biology : CB (2021) 3120: 4584-4595.e4. 250 114 IHC; tested species: mouse
Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal Migration.
Morozov YM, Mackie K, Rakic P
International journal of molecular sciences (2020) 2122: . 250 114 IHC; tested species: mouse
Background
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. After the release of glutamate from synaptic vesicles into the synaptic cleft during neurotransmission, excitatory amino acid transporters (EAATs) remove extracellular glutamate to avoid excitotoxic levels.
Five EAATs with differential expression patterns have been described so far: EAAT 1, also referred to as GLAST and SLC1A3, has neuroprotective potential following ischemia and is expressed by reactive astrocytes and activated microglia. EAAT 2 (GLT-1, SLC1A2) is the most abundant and primarily expressed in astrocytes. EAAT 3 / SLC1A1 is expressed in neurons and has also been shown to be involved in the uptake of extracelluar cysteine. EAAT 4 shows weak expression in the forebrain and high levels in Purkinje cells of the cerebellum. EAAT 5 has only been described for humans and is primarily expressed in the retina.