Cat. No.: 218 111BT
Amount: 100 µg
Price:
$465.00
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| Cat. No. 218 111BT |
100 µg purified IgG, lyophilized, labeled with Biotin.
Biotin is a small vitamin B complex molecule. Its small size minimizes interference with antibody binding sites and allows for efficient conjugation without compromising antibody functionality. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Label | biotin |
| Clone | NT78 |
| Subtype | IgG2b (κ light chain) |
| Immunogen | Synthetic peptide corresponding to AA 1 to 16 from human Abeta (UniProt Id: P05067) |
| Epitop |
AA 4 to 16 from human Abeta (UniProt Id: P05067) |
| Reactivity |
Reacts with: human (P05067), mouse (P12023). Other species not tested yet. |
| Specificity | Specific for Abeta 38, 40, 42, 43. Due to sequence homology, a cross-reactivity to unprocessed APP cannot be excluded. |
| Remarks |
WB: Boil membrane after blotting for 3min. |
| Data sheet | 218_111bt.pdf |
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Amyloid deposits, also called plaques, of Alzheimer's patients consist of several protein components like the amyloid beta-peptides (Abeta, Aβ) 1-40/42/43 and additional C- and N-terminally modified fragments of Abeta as for instance Abeta pE3 and Abeta pE11.
An additional Abeta variant, Abeta38, is more soluble compared to other Abeta species and is not found in plaques of sporadic Alzheimer´s cases. However, it is detected in the blood-vessel walls of a subset of patients with severe cerebral amyloid angiopathy. It especially accumulates in brains of patients carrying mutations in the Abeta coding region.
Cleavage of amyloid precursor protein APP by β- and γ- secretases results in the generation of the Aβ (βA4)peptide, whereas α-secretase cleaves within the Aβ sequence and prevents the formation of Abeta from APP.