Cat. No.: 197 003
Amount: 50 µg
Price:
$455.00
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| Cat. No. 197 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 2 to 75 from mouse ZnT3 (UniProt Id: P97441) |
| Reactivity |
Reacts with: rat (Q6QIX3), mouse (P97441). No signal: zebrafish. Other species not tested yet. |
| Specificity | K.O. validated PubMed: 35263617 |
| Matching control protein/peptide | 197-0P |
| Data sheet | 197_003.pdf |
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The essential micronutrient zinc plays an important role in many biological processes like growth, development and reproduction. It is found in the active site of many enzymes, where ionization, polarization or replacement of Zn2+ bound water is involved in catalytic reactions. As a charged ion Zn2+ cannot cross biological membranes by simple diffusion and must be transported into or out of cells by specialized transport mechanisms. Four Zn transporter proteins, ZnT 1 to ZnT 4, have been cloned. All of them contain several transmembrane domains and a histidine rich intracellular loop.
In the central nervous system Zn plays important roles in synaptic function and plasticity. At synapses Zn is stored in synaptic vesicles by a mechanism depending on the integral membrane protein ZnT 3.