Cat. No.: 191 203
Amount: 50 µg
Price:
$375.00
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| Cat. No. 191 203 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 900 to 922 from human mGluR7b (UniProt Id: Q14831-2) |
| Reactivity |
Reacts with: rat (F1LWV8), human (Q14831-2), mouse (G5E8D5). Other species not tested yet. |
| Specificity | Specific for mGluR7b. Does not cross-react with mGluR7a. |
| Remarks |
IHC: Suitable for IHC on rat tissue. Negative results on mouse tissue. |
| Data sheet | 191_203.pdf |
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Glutamate is the main excitatory neurotransmitter in the vertebrate nervous system and regulates a number of cellular signaling pathways. In addition to the ionotropic glutamate receptors of the NMDA, AMPA and kainate type, eight metabotropic receptors (mGluR1 - 8) have been described so far (1). This receptor family can be subdivided into three groups (2): Group I receptors (mGluR1, mGluR5) are activated by dihydroxyphenylglycine (DHPG) (3), group II receptors (mGluR2, mGluR3) by dicarboxycyclopropylglycine (DCG-IV), and group III receptors (mGluR4, mGluR6, mGluR7, mGluR8) by aminophosphonobutyrate (L-AP4) (4).