Synaptic Systems

Cat. No.: 156 003

Amount: 50 µg

Price: $480.00

Cat. No. 156 003	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 500 up to 1 : 2000 (AP staining) gallery IP: yes ICC: 1 : 1000 gallery IHC: 1 : 1000 gallery IHC-P: 1 : 1000 gallery ELISA: yes (see remarks)
Immunogen	Full-length recombinant mouse Arc (UniProt Id: Q9WV31)
Reactivity	Reacts with: rat (Q63053), mouse (Q9WV31). No signal: zebrafish. Other species not tested yet.
Specificity	Specific for arc. K.O. validated PubMed: 22539853
Remarks	ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 156 011 as capture antibody.
Data sheet	156_003.pdf

References for Arc - 156 003

PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome.
Xu J, Erlendsson S, Singh M, Holling GA, Regier M, Ibiricu I, Einstein J, Hantak MP, Day GS, Piquet AL, Smith TL, et al.
Cell (2024) 1874: 831-845.e19. 156 003 WB; tested species: rat

MSK1 is required for the experience- and ampakine-dependent enhancement of spatial reference memory and reversal learning and for the induction of Arc and BDNF.
Morè L, Privitera L, Lopes M, Arthur JSC, Lauterborn JC, Corrêa SAL, Frenguelli BG
Neuropharmacology (2024) : 110110. 156 003 WB; tested species: mouse

Biphasic Npas4 expression promotes inhibitory plasticity and suppression of fear memory consolidation in mice.
Brito DVC, Kupke J, Sokolov R, Cambridge S, Both M, Bengtson CP, Rozov A, Oliveira AMM
Molecular psychiatry (2024) : . 156 003 WB; tested species: mouse

Neuronal activity drives IGF2 expression from pericytes to form long-term memory.
Pandey K, Bessières B, Sheng SL, Taranda J, Osten P, Sandovici I, Constancia M, Alberini CM
Neuron (2023) 11123: 3819-3836.e8. 156 003 WB, IHC; tested species: mouse

Arc controls alcohol cue relapse by a central amygdala mechanism.
Pagano R, Salamian A, Zielinski J, Beroun A, Nalberczak-Skóra M, Skonieczna E, Cały A, Tay N, Banaschewski T, Desrivières S, Grigis A, et al.
Molecular psychiatry (2023) 282: 733-745. 156 003 WB, IHC; KO verified; tested species: mouse

Light activates Ube3a, an Angelman syndrome-associated gene, by mediating the chromatin structures during postnatal development of mouse retina.
Lin CW, Cheng YC, Yang CH, Huang HS
Journal of neurochemistry (2023) 1676: 766-777. 156 003 WB; tested species: mouse

Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo.
Mergiya TF, Gundersen JET, Kanhema T, Brighter G, Ishizuka Y, Bramham CR
Frontiers in molecular neuroscience (2023) 16: 1142361. 156 003 WB; tested species: rat

Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function.
Ishizuka Y, Mergiya TF, Baldinotti R, Xu J, Hallin EI, Markússon S, Kursula P, Bramham CR
Neurochemical research (2022) : . 156 003 WB; tested species: rat

Sex-dependent responsiveness of hippocampal neurons to sex neurosteroids: A role of Arc/Arg3.1.
Brökling J, Brunne B, Rune GM
Journal of neuroendocrinology (2022) : e13090. 156 003 WB, ICC; tested species: rat

The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis.
George AJ, Dong B, Lail H, Gomez M, Hoffiz YC, Ware CB, Fang N, Murphy AZ, Hrabovszky E, Wanders D, Mabb AM, et al.
iScience (2022) 256: 104386. 156 003 WB; tested species: mouse

Synapse-specific changes in Arc and BDNF in rat hippocampus following chronic temporal lobe epilepsy.
Egbenya DL, Hussain S, Lai YC, Anderson AE, Davanger S
Neuroscience research (2022) : . 156 003 WB, EM; tested species: rat

Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK.
Walczyk-Mooradally A, Holborn J, Singh K, Tyler M, Patnaik D, Wesseling H, Brandon NJ, Steen J, Graether SP, Haggarty SJ, Lalonde J, et al.
Journal of neurochemistry (2021) 1585: 1058-1073. 156 003 WB; tested species: mouse

Nrg1 haploinsufficiency alters inhibitory cortical circuits.
Navarro-Gonzalez C, Carceller H, Benito Vicente M, Serra I, Navarrete M, Domínguez-Canterla Y, Rodríguez-Prieto Á, González-Manteiga A, Fazzari P
Neurobiology of disease (2021) 157: 105442. 156 003 WB; tested species: mouse

Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice.
Prieto M, Folci A, Poupon G, Schiavi S, Buzzelli V, Pronot M, François U, Pousinha P, Lattuada N, Abelanet S, Castagnola S, et al.
Nature communications (2021) 121: 1557. 156 003 WB; tested species: mouse

Melatonin alters neuronal architecture and increases cysteine-rich protein 1 signaling in the male mouse hippocampus.
Ang MJ, Kang S, Moon C
Journal of neuroscience research (2020) : . 156 003 WB; tested species: mouse

Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation.
Montecinos-Oliva C, Arrázola MS, Jara C, Tapia-Rojas C, Inestrosa NC
Pharmaceuticals (Basel, Switzerland) (2020) 132: . 156 003 WB; tested species: mouse

Neuronal ensemble-specific DNA methylation strengthens engram stability.
Gulmez Karaca K, Kupke J, Brito DVC, Zeuch B, Thome C, Weichenhan D, Lutsik P, Plass C, Oliveira AMM
Nature communications (2020) 111: 639. 156 003 WB, IHC; tested species: mouse

Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons.
Klein ME, Younts TJ, Cobo CF, Buxbaum AR, Aow J, Erdjument-Bromage H, Richard S, Malinow R, Neubert TA, Singer RH, Castillo PE, et al.
Cell reports (2019) 297: 1789-1799.e6. 156 003 WB; tested species: mouse

Firing Rate Homeostasis Can Occur in the Absence of Neuronal Activity-Regulated Transcription.
Tyssowski KM, Letai KC, Rendall SD, Tan C, Nizhnik A, Kaeser PS, Gray JM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3950: 9885-9899. 156 003 WB; KO verified; tested species: mouse

Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia.
Yu-Taeger L, Ott T, Bonsi P, Tomczak C, Wassouf Z, Martella G, Sciamanna G, Imbriani P, Ponterio G, Tassone A, Schulze-Hentrich JM, et al.
Neurobiology of disease (2019) : 104634. 156 003 WB; tested species: rat

Disturbed prefrontal cortex activity in the absence of schizophrenia-like behavioral dysfunction in Arc/Arg3.1 deficient mice.
Gao X, Grendel J, Muhia M, Castro-Gomez S, Süsens U, Isbrandt D, Kneussel M, Kuhl D, Ohana O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 156 003 WB; KO verified; tested species: mouse

Upf1 regulates neurite outgrowth and branching by transcriptional and post-transcriptional modulation of Arc.
Ryu HG, Seo JY, Jung Y, Kim SW, Kim E, Jang SK, Kim KT
Journal of cell science (2019) 1322: . 156 003 WB, ICC; KD verified; tested species: mouse

Neurobiological substrates of persistent working memory deficits and cocaine-seeking in the prelimbic cortex of rats with a history of extended access to cocaine self-administration.
Gobin C, Shallcross J, Schwendt M
Neurobiology of learning and memory (2019) : . 156 003 WB; tested species: rat

Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat basolateral amygdala.
Bessières B, Jia M, Travaglia A, Alberini CM
Learning & memory (Cold Spring Harbor, N.Y.) (2019) 2611: 436-448. 156 003 WB; tested species: rat

Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat medial prefrontal cortex.
Jia M, Travaglia A, Pollonini G, Fedele G, Alberini CM
Learning & memory (Cold Spring Harbor, N.Y.) (2018) 2510: 533-543. 156 003 WB; tested species: rat

StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins.
Jacobs CL, Badiee RK, Lin MZ
Nature methods (2018) 157: 523-526. 156 003 WB; tested species: human

The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, et al.
Neuron (2018) : . 156 003 WB, ICC; tested species: mouse

MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1.
Carmichael RE, Wilkinson KA, Craig TJ, Ashby MC, Henley JM
Scientific reports (2018) 81: 5263. 156 003 WB; tested species: rat

Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes.
Frank RAW, Zhu F, Komiyama NH, Grant SGN
Journal of neurochemistry (2017) 1424: 504-511. 156 003 WB; tested species: mouse

Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation.
Kang MS, Choi TY, Ryu HG, Lee D, Lee SH, Choi SY, Kim KT
The Journal of experimental medicine (2017) 21410: 2947-2966. 156 003 WB; tested species: mouse

BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury.
Chumak T, Rüttiger L, Lee SC, Campanelli D, Zuccotti A, Singer W, Popelář J, Gutsche K, Geisler HS, Schraven SP, Jaumann M, et al.
Molecular neurobiology (2016) 538: 5607-27. 156 003 WB, IHC

Intracellular mGluR5 plays a critical role in neuropathic pain.
Vincent K, Cornea VM, Jong YJ, Laferrière A, Kumar N, Mickeviciute A, Fung JS, Bandegi P, Ribeiro-da-Silva A, O'Malley KL, Coderre TJ, et al.
Nature communications (2016) 7: 10604. 156 003 WB

Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression.
Sethna F, Zhang M, Kaphzan H, Klann E, Autio D, Cox CL, Wang H
Journal of neuroscience research (2016) 945: 401-8. 156 003 WB

MSK1 regulates homeostatic and experience-dependent synaptic plasticity.
Corrêa SA, Hunter CJ, Palygin O, Wauters SC, Martin KJ, McKenzie C, McKelvey K, Morris RG, Pankratov Y, Arthur JS, Frenguelli BG, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3238: 13039-51. 156 003 WB; tested species: mouse

Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.
Niere F, Wilkerson JR, Huber KM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3217: 5924-36. 156 003 WB, ICC; KO verified; tested species: mouse

Post-training disruption of Arc protein expression in the anterior cingulate cortex impairs long-term memory for inhibitory avoidance training.
Holloway CM, McIntyre CK
Neurobiology of learning and memory (2011) 954: 425-32. 156 003 WB, IHC; tested species: rat

Astrocyte-neuron lactate transport is required for long-term memory formation.
Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, Alberini CM
Cell (2011) 1445: 810-23. 156 003 WB; tested species: rat

Memory-enhancing corticosterone treatment increases amygdala norepinephrine and Arc protein expression in hippocampal synaptic fractions.
McReynolds JR, Donowho K, Abdi A, McGaugh JL, Roozendaal B, McIntyre CK
Neurobiology of learning and memory (2010) 933: 312-21. 156 003 WB, IHC; tested species: rat

Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation.
Jourdi H, Hsu YT, Zhou M, Qin Q, Bi X, Baudry M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2009) 2927: 8688-97. 156 003 WB; tested species: rat

The levo enantiomer of amphetamine increases memory consolidation and gene expression in the hippocampus without producing locomotor stimulation.
Wiig KA, Whitlock JR, Epstein MH, Carpenter RL, Bear MF
Neurobiology of learning and memory (2009) 921: 106-13. 156 003 WB; tested species: rat

Activity-Regulated Cytoskeleton-Associated Protein Controls AMPAR Endocytosis through a Direct Interaction with Clathrin-Adaptor Protein 2.
DaSilva LL, Wall MJ, P de Almeida L, Wauters SC, Januário YC, Müller J, Corrêa SA
eNeuro () 33: . 156 003 IP, WB