quick order | cart
?
|
login
Home|||||||Technical Support|
Home > Products > 147 011

Gephyrin - 147 011

A protein associated with inhibitory neurotransmitter receptors
Monoclonal mouse purified IgG
Cat. No.: 147 011
Amount: 100 µg
Price: 425.00 €
Cat. No. 147 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: not recommended (see remarks)
IP: not recommended (see remarks)
ICC: 1 : 250 up to 1 : 1000 gallery  
IHC: 1 : 500 (see remarks) gallery  
IHC-P/FFPE: not tested yet
EM: yes
Clone mAb7a
Subtype IgG1 (κ light chain)
Immunogen Nativ Protein corresponding to AA 1 to 768 from rat Gephyrin (UniProt Id: Q03555)
Epitop Epitop: AA 264 to 276 from rat Gephyrin (UniProt Id: Q03555)
Reactivity Reacts with: human (Q9NQX3), rat (Q03555), mouse (Q8BUV3), pig, goldfish, zebrafish, chicken.
Other species not tested yet.
Specificity Specific for the brain specific 93 kDa splice variant phosphorylated at Ser-270. K.O. PubMed: 9812897
Remarks

WB: Clone 3B11 (cat. no. 147 111) is highly recommended.
IP: Clone 3B11 (cat. no. 147 111) is highly recommended.
IHC: Hybridoma supernatant (cat. no. 147 021) highly recommended. For best results use the protocol of Schneider Gasser et al., 2006.
Data sheet 147_011.pdf

References for Gephyrin - 147 011

Chemico-genetic discovery of astrocytic control of inhibition in vivo.
Takano T, Wallace JT, Baldwin KT, Purkey AM, Uezu A, Courtland JL, Soderblom EJ, Shimogori T, Maness PF, Eroglu C, Soderling SH, et al.
Nature (2020) : . 147 011 WB, ICC; tested species: mouse
Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model.
Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG
Scientific reports (2020) 101: 19606. 147 011 WB, IHC; tested species: mouse
Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.
Davenport EC, Szulc BR, Drew J, Taylor J, Morgan T, Higgs NF, López-Doménech G, Kittler JT
Cell reports (2019) 268: 2037-2051.e6. 147 011 WB, ICC, IHC; tested species: mouse
HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture.
Hu G, Niu F, Liao K, Periyasamy P, Sil S, Liu J, Dravid SM, Buch S
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2019) : . 147 011 WB, ICC, IHC; tested species: human,rat,monkey
The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
Shimell JJ, Shah BS, Cain SM, Thouta S, Kuhlmann N, Tatarnikov I, Jovellar DB, Brigidi GS, Kass J, Milnerwood AJ, Snutch TP, et al.
Cell reports (2019) 298: 2422-2437.e8. 147 011 WB, ICC; tested species: rat
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Nature chemical biology (2017) 132: 153-160. 147 011 WB, ICC; tested species: mouse
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM
The Journal of biological chemistry (2013) 28814: 9634-47. 147 011 WB, IP
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC
Science (New York, N.Y.) (2007) 3185847: 71-6. 147 011 WB; tested species: mouse
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM
The Journal of biological chemistry (2013) 28814: 9634-47. 147 011 WB, IP
Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.
Buffolo F, Petrosino V, Albini M, Moschetta M, Carlini F, Floss T, Kerlero de Rosbo N, Cesca F, Rocchi A, Uccelli A, Benfenati F, et al.
Cell death & disease (2021) 122: 180. 147 011 ICC; tested species: mouse
Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation.
Rajgor D, Purkey AM, Sanderson JL, Welle TM, Garcia JD, Dell'Acqua ML, Smith KR
Cell reports (2020) 3112: 107785. 147 011 ICC; tested species: rat
Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation.
Zhang K, Yu F, Zhu J, Han S, Chen J, Wu X, Chen Y, Shen T, Liao J, Guo W, Yang X, et al.
Cell reports (2020) 313: 107521. 147 011 ICC; tested species: human
Acute knockdown of Depdc5 leads to synaptic defects in mTOR-related epileptogenesis.
De Fusco A, Cerullo MS, Marte A, Michetti C, Romei A, Castroflorio E, Baulac S, Benfenati F
Neurobiology of disease (2020) : 104822. 147 011 ICC; tested species: mouse
Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior.
Salesse C, Charest J, Doucet-Beaupré H, Castonguay AM, Labrecque S, De Koninck P, Lévesque M
Cell reports (2020) 307: 2374-2386.e5. 147 011 ICC; tested species: mouse
Chemico-genetic discovery of astrocytic control of inhibition in vivo.
Takano T, Wallace JT, Baldwin KT, Purkey AM, Uezu A, Courtland JL, Soderblom EJ, Shimogori T, Maness PF, Eroglu C, Soderling SH, et al.
Nature (2020) : . 147 011 WB, ICC; tested species: mouse
Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia.
Park GH, Noh H, Shao Z, Ni P, Qin Y, Liu D, Beaudreault CP, Park JS, Abani CP, Park JM, Le DT, et al.
Nature neuroscience (2020) 2311: 1352-1364. 147 011 ICC; tested species: human
A GTPase-induced switch in phospholipid affinity of collybistin contributes to synaptic gephyrin clustering.
Kilisch M, Mayer S, Mitkovski M, Roehse H, Hentrich J, Schwappach B, Papadopoulos T
Journal of cell science (2020) : . 147 011 ICC; tested species: rat
Poly I:C induced maternal immune challenge reduces perineuronal net area and raises spontaneous network activity of hippocampal neurons in vitro.
Wegrzyn D, Manitz MP, Kostka M, Freund N, Juckel G, Faissner A
The European journal of neuroscience (2020) : . 147 011 ICC; tested species: mouse
Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse.
Crosby KC, Gookin SE, Garcia JD, Hahm KM, Dell'Acqua ML, Smith KR
Cell reports (2019) 2612: 3284-3297.e3. 147 011 ICC, IHC; tested species: rat
Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.
Davenport EC, Szulc BR, Drew J, Taylor J, Morgan T, Higgs NF, López-Doménech G, Kittler JT
Cell reports (2019) 268: 2037-2051.e6. 147 011 WB, ICC, IHC; tested species: mouse
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 147 011 ICC; tested species: mouse
βPix heterozygous mice have defects in neuronal morphology and social interaction.
Kwon Y, Lee SJ, Lee E, Kim D, Park D
Biochemical and biophysical research communications (2019) 5164: 1204-1210. 147 011 ICC; tested species: mouse
SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling.
Halff EF, Szulc BR, Lesept F, Kittler JT
Cell reports (2019) 299: 2599-2607.e6. 147 011 ICC; tested species: rat
HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture.
Hu G, Niu F, Liao K, Periyasamy P, Sil S, Liu J, Dravid SM, Buch S
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2019) : . 147 011 WB, ICC, IHC; tested species: human,rat,monkey
Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.
Gottschling C, Wegrzyn D, Denecke B, Faissner A
Scientific reports (2019) 91: 13939. 147 011 ICC; tested species: mouse
Biallelic DMXL2 mutations impair autophagy and cause Ohtahara syndrome with progressive course.
Esposito A, Falace A, Wagner M, Gal M, Mei D, Conti V, Pisano T, Aprile D, Cerullo MS, De Fusco A, Giovedì S, et al.
Brain : a journal of neurology (2019) : . 147 011 ICC; tested species: mouse
Regulation of dendrite morphology and excitatory synapse formation by zDHHC15.
Shah BS, Shimell JJ, Bamji SX
Journal of cell science (2019) 13213: . 147 011 ICC; tested species: rat
The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
Shimell JJ, Shah BS, Cain SM, Thouta S, Kuhlmann N, Tatarnikov I, Jovellar DB, Brigidi GS, Kass J, Milnerwood AJ, Snutch TP, et al.
Cell reports (2019) 298: 2422-2437.e8. 147 011 WB, ICC; tested species: rat
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.
Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, et al.
Neuron (2019) 1034: 617-626.e6. 147 011 ICC; tested species: human
Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice.
Uezu A, Hisey E, Kobayashi Y, Gao Y, Bradshaw TW, Devlin P, Rodriguiz R, Tata PR, Soderling S
eLife (2019) 8: . 147 011 ICC; tested species: mouse
Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling.
Brady ML, Pilli J, Lorenz-Guertin JM, Das S, Moon CE, Graff N, Jacob TC
Neuropharmacology (2018) 128: 324-339. 147 011 ICC; tested species: rat
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 147 011 ICC; tested species: mouse
Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength.
Ge Y, Kang Y, Cassidy RM, Moon KM, Lewis R, Wong ROL, Foster LJ, Craig AM
Neuron (2018) 973: 596-610.e8. 147 011 ICC, IHC; tested species: mouse
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, et al.
Science (New York, N.Y.) (2018) : . 147 011 ICC; tested species: rat
Prions activate a p38 MAPK synaptotoxic signaling pathway.
Fang C, Wu B, Le NTT, Imberdis T, Mercer RCC, Harris DA
PLoS pathogens (2018) 149: e1007283. 147 011 ICC; tested species: mouse
GARLH Family Proteins Stabilize GABAA Receptors at Synapses.
Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S
Neuron (2017) 935: 1138-1152.e6. 147 011 ICC
Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.
Patrizio A, Renner M, Pizzarelli R, Triller A, Specht CG
Scientific reports (2017) 71: 10899. 147 011 ICC; tested species: rat
Nanoscale Molecular Reorganization of the Inhibitory Postsynaptic Density Is a Determinant of GABAergic Synaptic Potentiation.
Pennacchietti F, Vascon S, Nieus T, Rosillo C, Das S, Tyagarajan SK, Diaspro A, Del Bue A, Petrini EM, Barberis A, Cella Zanacchi F, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 377: 1747-1756. 147 011 ICC
The antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro.
Dzyubenko E, Juckel G, Faissner A
Scientific reports (2017) 71: 11609. 147 011 ICC; tested species: mouse
Adaptive-illumination STED nanoscopy.
Heine J, Reuss M, Harke B, D'Este E, Sahl SJ, Hell SW
Proceedings of the National Academy of Sciences of the United States of America (2017) 11437: 9797-9802. 147 011 ICC; tested species: rat
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Nature chemical biology (2017) 132: 153-160. 147 011 WB, ICC; tested species: mouse
Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability.
Papadopoulos T, Schemm R, Grubmüller H, Brose N
The Journal of biological chemistry (2015) 29013: 8256-70. 147 011 ICC
Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, et al.
Nature communications (2015) 6: 6872. 147 011 ICC
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 147 011 ICC; tested species: rat
Plexin-B3 suppresses excitatory and promotes inhibitory synapse formation in rat hippocampal neurons.
Laht P, Tammaru E, Otsus M, Rohtla J, Tiismus L, Veske A
Experimental cell research (2015) 3352: 269-78. 147 011 ICC
Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5.
Brigidi GS, Santyr B, Shimell J, Jovellar B, Bamji SX
Nature communications (2015) 6: 8200. 147 011 ICC
Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons.
Varea O, Martin-de-Saavedra MD, Kopeikina KJ, Schürmann B, Fleming HJ, Fawcett-Patel JM, Bach A, Jang S, Peles E, Kim E, Penzes P, et al.
Proceedings of the National Academy of Sciences of the United States of America (2015) 11219: 6176-81. 147 011 ICC
A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
Vullhorst D, Mitchell RM, Keating C, Roychowdhury S, Karavanova I, Tao-Cheng JH, Buonanno A
Nature communications (2015) 6: 7222. 147 011 ICC
Proteomic analysis of glycine receptor β subunit (GlyRβ)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors.
Del Pino I, Koch D, Schemm R, Qualmann B, Betz H, Paarmann I
The Journal of biological chemistry (2014) 28916: 11396-409. 147 011 ICC; tested species: rat
Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.
Wang SH, Celic I, Choi SY, Riccomagno M, Wang Q, Sun LO, Mitchell SP, Vasioukhin V, Huganir RL, Kolodkin AL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3438: 12745-61. 147 011 ICC; tested species: mouse
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.
Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, et al.
Nature communications (2014) 5: 3921. 147 011 ICC; tested species: mouse
Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain.
Mishra A, Traut MH, Becker L, Klopstock T, Stein V, Klein R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3412: 4187-99. 147 011 ICC, IHC; tested species: mouse
High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons.
Nieland TJ, Logan DJ, Saulnier J, Lam D, Johnson C, Root DE, Carpenter AE, Sabatini BL
PloS one (2014) 93: e91744. 147 011 ICC; tested species: mouse
Differential control of thrombospondin over synaptic glycine and AMPA receptors in spinal cord neurons.
Hennekinne L, Colasse S, Triller A, Renner M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3328: 11432-9. 147 011 ICC; tested species: rat
Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites.
Specht CG, Izeddin I, Rodriguez PC, El Beheiry M, Rostaing P, Darzacq X, Dahan M, Triller A
Neuron (2013) 792: 308-21. 147 011 ICC; tested species: mouse
TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors.
Pribiag H, Stellwagen D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3340: 15879-93. 147 011 ICC; tested species: rat
Effects of distinct collybistin isoforms on the formation of GABAergic synapses in hippocampal neurons.
Körber C, Richter A, Kaiser M, Schlicksupp A, Mükusch S, Kuner T, Kirsch J, Kuhse J
Molecular and cellular neurosciences (2012) 503-4: 250-9. 147 011 ICC
Tracing synaptic connectivity onto embryonic stem cell-derived neurons.
Garcia I, Huang L, Ung K, Arenkiel BR
Stem cells (Dayton, Ohio) (2012) 3010: 2140-51. 147 011 ICC; tested species: mouse
Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrin.
Tretter V, Kerschner B, Milenkovic I, Ramsden SL, Ramerstorfer J, Saiepour L, Maric HM, Moss SJ, Schindelin H, Harvey RJ, Sieghart W, et al.
The Journal of biological chemistry (2011) 28643: 37702-11. 147 011 ICC; tested species: mouse
Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis.
Hughes EG, Elmariah SB, Balice-Gordon RJ
Molecular and cellular neurosciences (2010) 431: 136-45. 147 011 ICC; tested species: rat
Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy.
Förstera B, Belaidi AA, Jüttner R, Bernert C, Tsokos M, Lehmann TN, Horn P, Dehnicke C, Schwarz G, Meier JC
Brain : a journal of neurology (2010) 133Pt 12: 3778-94. 147 011 ICC
Induction of GABAergic postsynaptic differentiation by alpha-neurexins.
Kang Y, Zhang X, Dobie F, Wu H, Craig AM
The Journal of biological chemistry (2008) 2834: 2323-34. 147 011 ICC; tested species: rat
Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons.
Hartman KN, Pal SK, Burrone J, Murthy VN
Nature neuroscience (2006) 95: 642-9. 147 011 ICC
Structure function and splice site analysis of the synaptogenic activity of the neurexin-1 beta LNS domain.
Graf ER, Kang Y, Hauner AM, Craig AM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2616: 4256-65. 147 011 ICC
Neuronal cotransport of glycine receptor and the scaffold protein gephyrin.
Maas C, Tagnaouti N, Loebrich S, Behrend B, Lappe-Siefke C, Kneussel M
The Journal of cell biology (2006) 1723: 441-51. 147 011 ICC
Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors.
Jacob TC, Bogdanov YD, Magnus C, Saliba RS, Kittler JT, Haydon PG, Moss SJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2005) 2545: 10469-78. 147 011 ICC
A gephyrin-related mechanism restraining glycine receptor anchoring at GABAergic synapses.
Meier J, Grantyn R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2004) 246: 1398-405. 147 011 ICC
GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites.
Rathgeber L, Gromova KV, Schaefer I, Breiden P, Lohr C, Kneussel M
European journal of cell biology () 943-4: 173-8. 147 011 ICC
Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain.
Lorenzo LE, Godin AG, Ferrini F, Bachand K, Plasencia-Fernandez I, Labrecque S, Girard AA, Boudreau D, Kianicka I, Gagnon M, Doyon N, et al.
Nature communications (2020) 111: 869. 147 011 IHC; tested species: rat
Piriform cortex alterations in the Ts65Dn model for down syndrome.
Carbonell J, Blasco-Ibáñez JM, Crespo C, Nácher J, Varea E
Brain research (2020) 1747: 147031. 147 011 IHC; tested species: mouse
Neurotransmitters and motoneuron contacts of multifunctional and behaviorally specialized turtle spinal cord interneurons.
Bannatyne BA, Hao 郝赵哲 ZZ, Dyer GMC, Watanabe M, Maxwell DJ, Berkowitz A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 147 011 IHC
Glutamate transporter 1-expressing glia in the rat substantia nigra-Morphometric analysis and relationships to synapses.
Kessler JP, Salin P, Kerkerian-Le Goff L
Glia (2020) : . 147 011 IHC; tested species: rat
Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants.
Fazel Darbandi S, Robinson Schwartz SE, Pai EL, Everitt A, Turner ML, Cheyette BNR, Willsey AJ, State MW, Sohal VS, Rubenstein JLR
Cell reports (2020) 312: 107495. 147 011 IHC; tested species: mouse
Dynamics of the Fragile X Mental Retardation Protein Correlates with Cellular and Synaptic Properties in Primary Auditory Neurons following Afferent Deprivation.
Yu X, Wang X, Sakano H, Zorio DAR, Wang Y
The Journal of comparative neurology (2020) : . 147 011 IHC; tested species: chicken
Semilunar granule cells are the primary source of the perisomatic excitatory innervation onto parvalbumin-expressing interneurons in the dentate gyrus.
Rovira-Esteban L, Hájos N, Nagy GA, Crespo C, Nacher J, Varea E, Blasco-Ibáñez JM
eNeuro (2020) : . 147 011 IHC; tested species: mouse
SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury.
Sauerbeck AD, Gangolli M, Reitz SJ, Salyards MH, Kim SH, Hemingway C, Gratuze M, Makkapati T, Kerschensteiner M, Holtzman DM, Brody DL, et al.
Neuron (2020) 1072: 257-273.e5. 147 011 IHC; tested species: mouse
Role of endocannabinoid signaling in a septohabenular pathway in the regulation of anxiety- and depressive-like behavior.
Vickstrom CR, Liu X, Liu S, Hu MM, Mu L, Hu Y, Yu H, Love SL, Hillard CJ, Liu QS
Molecular psychiatry (2020) : . 147 011 IHC; tested species: mouse
Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model.
Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG
Scientific reports (2020) 101: 19606. 147 011 WB, IHC; tested species: mouse
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease.
Richetin K, Steullet P, Pachoud M, Perbet R, Parietti E, Maheswaran M, Eddarkaoui S, Bégard S, Pythoud C, Rey M, Caillierez R, et al.
Nature neuroscience (2020) 2312: 1567-1579. 147 011 IHC; tested species: mouse
Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits.
Exposito-Alonso D, Osório C, Bernard C, Pascual-García S, Del Pino I, Marín O, Rico B
eLife (2020) 9: . 147 011 IHC; tested species: mouse
HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture.
Hu G, Niu F, Liao K, Periyasamy P, Sil S, Liu J, Dravid SM, Buch S
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2019) : . 147 011 WB, ICC, IHC; tested species: human,rat,monkey
Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex.
Kroon T, van Hugte E, van Linge L, Mansvelder HD, Meredith RM
Scientific reports (2019) 91: 5037. 147 011 IHC; tested species: mouse
Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse.
Crosby KC, Gookin SE, Garcia JD, Hahm KM, Dell'Acqua ML, Smith KR
Cell reports (2019) 2612: 3284-3297.e3. 147 011 ICC, IHC; tested species: rat
Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
Hu HY, Kruijssen DLH, Frias CP, Rózsa B, Hoogenraad CC, Wierenga CJ
Cell reports (2019) 273: 666-675.e5. 147 011 IHC; tested species: mouse
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.
Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, et al.
Nature neuroscience (2019) : . 147 011 IHC; tested species: human,mouse
Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch.
Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, Eva C, Goulding M
Cell reports (2019) 283: 625-639.e6. 147 011 IHC; tested species: mouse
Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation.
Frias CP, Liang J, Bresser T, Scheefhals L, van Kesteren M, van Dorland R, Hu HY, Bodzeta A, van Bergen En Henegouwen PMP, Hoogenraad CC, Wierenga CJ, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3922: 4221-4237. 147 011 IHC; tested species: mouse
Long-Lasting Rescue of Network and Cognitive Dysfunction in a Genetic Schizophrenia Model.
Mukherjee A, Carvalho F, Eliez S, Caroni P
Cell (2019) 1786: 1387-1402.e14. 147 011 IHC; tested species: mouse
Disturbed prefrontal cortex activity in the absence of schizophrenia-like behavioral dysfunction in Arc/Arg3.1 deficient mice.
Gao X, Grendel J, Muhia M, Castro-Gomez S, Süsens U, Isbrandt D, Kneussel M, Kuhl D, Ohana O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 147 011 IHC; tested species: mouse
Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.
Fossati M, Assendorp N, Gemin O, Colasse S, Dingli F, Arras G, Loew D, Charrier C
Neuron (2019) : . 147 011 IHC; tested species: mouse
Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis.
Hollnagel JO, Elzoheiry S, Gorgas K, Kins S, Beretta CA, Kirsch J, Kuhse J, Kann O, Kiss E
PloS one (2019) 141: e0209228. 147 011 IHC; tested species: mouse
Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.
Davenport EC, Szulc BR, Drew J, Taylor J, Morgan T, Higgs NF, López-Doménech G, Kittler JT
Cell reports (2019) 268: 2037-2051.e6. 147 011 WB, ICC, IHC; tested species: mouse
Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions.
Meng X, McGraw CM, Wang W, Jing J, Yeh SY, Wang L, Lopez J, Brown AM, Lin T, Chen W, Xue M, et al.
eLife (2019) 8: . 147 011 IHC; tested species: mouse
Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM.
Tai Y, Gallo NB, Wang M, Yu JR, Van Aelst L
Neuron (2019) : . 147 011 IHC; tested species: mouse
Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity.
Fazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, et al.
Neuron (2018) 1004: 831-845.e7. 147 011 IHC; tested species: mouse
Regulation of Synapse Development by Vgat Deletion from ErbB4-Positive Interneurons.
Lin TW, Tan Z, Barik A, Yin DM, Brudvik E, Wang H, Xiong WC, Mei L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3810: 2533-2550. 147 011 IHC; tested species: mouse
Developmental pattern and structural factors of dendritic survival in cerebellar granule cells in vivo.
Dhar M, Hantman AW, Nishiyama H
Scientific reports (2018) 81: 17561. 147 011 IHC; tested species: mouse
Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength.
Ge Y, Kang Y, Cassidy RM, Moon KM, Lewis R, Wong ROL, Foster LJ, Craig AM
Neuron (2018) 973: 596-610.e8. 147 011 ICC, IHC; tested species: mouse
Long-lasting effects of early-life intervention in mice on adulthood behaviour, GABAA receptor subunit expression and synaptic clustering.
Skilbeck KJ, Johnston GAR, Hinton T
Pharmacological research (2018) 128: 179-189. 147 011 IHC; tested species: mouse
GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.
Jiang DY, Wu Z, Forsyth CT, Hu Y, Yee SP, Chen G
Molecular brain (2018) 111: 31. 147 011 IHC; tested species: mouse
Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons.
Wamsley B, Jaglin XH, Favuzzi E, Quattrocolo G, Nigro MJ, Yusuf N, Khodadadi-Jamayran A, Rudy B, Fishell G
Neuron (2018) : . 147 011 IHC; tested species: mouse
Postsynaptic FMRP regulates synaptogenesis in vivo in the developing cochlear nucleus.
Wang X, Zorio DAR, Schecterson L, Lu Y, Wang Y
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 147 011 IHC; tested species: chicken
Synaptic distribution of individually labeled mitral cells in the external plexiform layer of the mouse olfactory bulb.
Matsuno T, Kiyokage E, Toida K
The Journal of comparative neurology (2017) 5257: 1633-1648. 147 011 IHC; tested species: mouse
The excitatory/inhibitory input to orexin/hypocretin neuron soma undergoes day/night reorganization.
Laperchia C, Imperatore R, Azeez IA, Del Gallo F, Bertini G, Grassi-Zucconi G, Cristino L, Bentivoglio M
Brain structure & function (2017) 2228: 3847-3859. 147 011 IHC; tested species: mouse
Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.
Favuzzi E, Marques-Smith A, Deogracias R, Winterflood CM, Sánchez-Aguilera A, Mantoan L, Maeso P, Fernandes C, Ewers H, Rico B
Neuron (2017) 953: 639-655.e10. 147 011 IHC; tested species: mouse
Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state.
Fuchs T, Jefferson SJ, Hooper A, Yee PH, Maguire J, Luscher B
Molecular psychiatry (2017) 226: 920-930. 147 011 IHC
Iterative expansion microscopy.
Chang JB, Chen F, Yoon YG, Jung EE, Babcock H, Kang JS, Asano S, Suk HJ, Pak N, Tillberg PW, Wassie AT, et al.
Nature methods (2017) 146: 593-599. 147 011 IHC; tested species: mouse
Differential role of GABAA receptors and neuroligin 2 for perisomatic GABAergic synapse formation in the hippocampus.
Panzanelli P, Früh S, Fritschy JM
Brain structure & function (2017) 2229: 4149-4161. 147 011 IHC; tested species: mouse
Enrichment of GABAA Receptor α-Subunits on the Axonal Initial Segment Shows Regional Differences.
Gao Y, Heldt SA
Frontiers in cellular neuroscience (2016) 10: 39. 147 011 IHC
Recurrent Inhibition to the Medial Nucleus of the Trapezoid Body in the Mongolian Gerbil (Meriones Unguiculatus).
Dondzillo A, Thompson JA, Klug A
PloS one (2016) 118: e0160241. 147 011 IHC
Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer.
Bartel DL, Rela L, Hsieh L, Greer CA
The Journal of comparative neurology (2015) 5238: 1145-61. 147 011 IHC
Interneuron- and GABA(A) receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells.
He Q, Duguid I, Clark B, Panzanelli P, Patel B, Thomas P, Fritschy JM, Smart TG
Nature communications (2015) 6: 7364. 147 011 IHC
Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb.
Deprez F, Pallotto M, Vogt F, Grabiec M, Virtanen MA, Tyagarajan SK, Panzanelli P, Fritschy JM
The Journal of comparative neurology (2015) 52313: 1998-2016. 147 011 IHC, EM
A unique ion channel clustering domain on the axon initial segment of mammalian neurons.
King AN, Manning CF, Trimmer JS
The Journal of comparative neurology (2014) 52211: 2594-608. 147 011 IHC; tested species: rat
Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain.
Mishra A, Traut MH, Becker L, Klopstock T, Stein V, Klein R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3412: 4187-99. 147 011 ICC, IHC; tested species: mouse
Gephyrin clusters are absent from small diameter primary afferent terminals despite the presence of GABA(A) receptors.
Lorenzo LE, Godin AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De Koninck Y
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3424: 8300-17. 147 011 IHC; tested species: rat
Spatial relationships between GABAergic and glutamatergic synapses on the dendrites of distinct types of mouse retinal ganglion cells across development.
Bleckert A, Parker ED, Kang Y, Pancaroglu R, Soto F, Lewis R, Craig AM, Wong RO
PloS one (2013) 87: e69612. 147 011 IHC; tested species: mouse
Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse.
Hruskova B, Trojanova J, Kulik A, Kralikova M, Pysanenko K, Bures Z, Syka J, Trussell LO, Turecek R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3247: 17012-24. 147 011 IHC, EM
Distribution of gephyrin-immunoreactivity in the trigeminal motor nucleus: an immunohistochemical study in rats.
Li Z, Ge S, Zhang F, Zhang T, Mizuno N, Hioki H, Kaneko T, Gao G, Li J
Anatomical record (Hoboken, N.J. : 2007) (2012) 2954: 641-51. 147 011 IHC, EM; tested species: rat
Somatostatin varicosities contain the vesicular GABA transporter and contact orexin neurons in the hypothalamus.
Toossi H, Del Cid-Pellitero E, Stroh T, Jones BE
The European journal of neuroscience (2012) 3610: 3388-95. 147 011 IHC
Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.
Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM
The Journal of physiology (2011) 589Pt 20: 4959-80. 147 011 IHC, EM; tested species: mouse
Quantitative study of NPY-expressing GABAergic neurons and axons in rat spinal dorsal horn.
Polgár E, Sardella TC, Watanabe M, Todd AJ
The Journal of comparative neurology (2011) 5196: 1007-23. 147 011 IHC; tested species: rat
Mixed GABA-glycine synapses delineate a specific topography in the nucleus tractus solitarii of adult rat.
Dufour A, Tell F, Kessler JP, Baude A
The Journal of physiology (2010) 588Pt 7: 1097-115. 147 011 IHC; tested species: rat
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome.
Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC
The Journal of comparative neurology (2009) 5124: 453-66. 147 011 IHC; tested species: mouse
Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones.
Peden DR, Petitjean CM, Herd MB, Durakoglugil MS, Rosahl TW, Wafford K, Homanics GE, Belelli D, Fritschy JM, Lambert JJ
The Journal of physiology (2008) 5864: 965-87. 147 011 IHC; tested species: mouse
Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of gamma-aminobutyric acid type A receptor alpha1 subunit knockout mice.
Kralic JE, Sidler C, Parpan F, Homanics GE, Morrow AL, Fritschy JM
The Journal of comparative neurology (2006) 4954: 408-21. 147 011 IHC
Synaptic destabilization by neuronal Nogo-A.
Aloy EM, Weinmann O, Pot C, Kasper H, Dodd DA, Rülicke T, Rossi F, Schwab ME
Brain cell biology (2006) 352-3: 137-56. 147 011 IHC
Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin.
Grady RM, Wozniak DF, Ohlemiller KK, Sanes JR
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2611: 2841-51. 147 011 IHC
Immunofluorescence in brain sections: simultaneous detection of presynaptic and postsynaptic proteins in identified neurons.
Schneider Gasser EM, Straub CJ, Panzanelli P, Weinmann O, Sassoè-Pognetto M, Fritschy JM
Nature protocols (2006) 14: 1887-97. 147 011 IHC
Neurochemical anatomy of the zebrafish retina as determined by immunocytochemistry.
Yazulla S, Studholme KM
Journal of neurocytology (2001) 307: 551-92. 147 011 IHC; tested species: zebrafish
Glycinergic miniature synaptic currents and receptor cluster sizes differ between spinal cord interneurons.
Oleskevich S, Alvarez FJ, Walmsley B
Journal of neurophysiology (1999) 821: 312-9. 147 011 IHC
Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity.
Feng G, Tintrup H, Kirsch J, Nichol MC, Kuhse J, Betz H, Sanes JR
Science (New York, N.Y.) (1998) 2825392: 1321-4. 147 011 IHC; KO verified; tested species: mouse
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.
Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, et al.
Nature (2020) : . 147 011 IHC-P; tested species: mouse
Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb.
Deprez F, Pallotto M, Vogt F, Grabiec M, Virtanen MA, Tyagarajan SK, Panzanelli P, Fritschy JM
The Journal of comparative neurology (2015) 52313: 1998-2016. 147 011 IHC, EM
Distribution of gephyrin-immunoreactivity in the trigeminal motor nucleus: an immunohistochemical study in rats.
Li Z, Ge S, Zhang F, Zhang T, Mizuno N, Hioki H, Kaneko T, Gao G, Li J
Anatomical record (Hoboken, N.J. : 2007) (2012) 2954: 641-51. 147 011 IHC, EM; tested species: rat
Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse.
Hruskova B, Trojanova J, Kulik A, Kralikova M, Pysanenko K, Bures Z, Syka J, Trussell LO, Turecek R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3247: 17012-24. 147 011 IHC, EM
Synaptic reorganization in the adult rat's ventral cochlear nucleus following its total sensory deafferentation.
Hildebrandt H, Hoffmann NA, Illing RB
PloS one (2011) 68: e23686. 147 011 EM; tested species: rat
Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.
Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM
The Journal of physiology (2011) 589Pt 20: 4959-80. 147 011 IHC, EM; tested species: mouse
Monoclonal antibodies and peptide mapping reveal structural similarities between the subunits of the glycine receptor of rat spinal cord.
Pfeiffer F, Simler R, Grenningloh G, Betz H
Proceedings of the National Academy of Sciences of the United States of America (1984) 8122: 7224-7. 147 011
Cat. No.: 147 011
Quantity: 100 µg
Price: 425.00 €
Chemico-genetic discovery of astrocytic control of inhibition in vivo.
Takano T, Wallace JT, Baldwin KT, Purkey AM, Uezu A, Courtland JL, Soderblom EJ, Shimogori T, Maness PF, Eroglu C, Soderling SH, et al.
Nature (2020) : . 147 011 WB, ICC; tested species: mouse
Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model.
Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG
Scientific reports (2020) 101: 19606. 147 011 WB, IHC; tested species: mouse
Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.
Davenport EC, Szulc BR, Drew J, Taylor J, Morgan T, Higgs NF, López-Doménech G, Kittler JT
Cell reports (2019) 268: 2037-2051.e6. 147 011 WB, ICC, IHC; tested species: mouse
HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture.
Hu G, Niu F, Liao K, Periyasamy P, Sil S, Liu J, Dravid SM, Buch S
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2019) : . 147 011 WB, ICC, IHC; tested species: human,rat,monkey
The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
Shimell JJ, Shah BS, Cain SM, Thouta S, Kuhlmann N, Tatarnikov I, Jovellar DB, Brigidi GS, Kass J, Milnerwood AJ, Snutch TP, et al.
Cell reports (2019) 298: 2422-2437.e8. 147 011 WB, ICC; tested species: rat
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Nature chemical biology (2017) 132: 153-160. 147 011 WB, ICC; tested species: mouse
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM
The Journal of biological chemistry (2013) 28814: 9634-47. 147 011 WB, IP
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC
Science (New York, N.Y.) (2007) 3185847: 71-6. 147 011 WB; tested species: mouse
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM
The Journal of biological chemistry (2013) 28814: 9634-47. 147 011 WB, IP
Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.
Buffolo F, Petrosino V, Albini M, Moschetta M, Carlini F, Floss T, Kerlero de Rosbo N, Cesca F, Rocchi A, Uccelli A, Benfenati F, et al.
Cell death & disease (2021) 122: 180. 147 011 ICC; tested species: mouse
Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation.
Rajgor D, Purkey AM, Sanderson JL, Welle TM, Garcia JD, Dell'Acqua ML, Smith KR
Cell reports (2020) 3112: 107785. 147 011 ICC; tested species: rat
Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation.
Zhang K, Yu F, Zhu J, Han S, Chen J, Wu X, Chen Y, Shen T, Liao J, Guo W, Yang X, et al.
Cell reports (2020) 313: 107521. 147 011 ICC; tested species: human
Acute knockdown of Depdc5 leads to synaptic defects in mTOR-related epileptogenesis.
De Fusco A, Cerullo MS, Marte A, Michetti C, Romei A, Castroflorio E, Baulac S, Benfenati F
Neurobiology of disease (2020) : 104822. 147 011 ICC; tested species: mouse
Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior.
Salesse C, Charest J, Doucet-Beaupré H, Castonguay AM, Labrecque S, De Koninck P, Lévesque M
Cell reports (2020) 307: 2374-2386.e5. 147 011 ICC; tested species: mouse
Chemico-genetic discovery of astrocytic control of inhibition in vivo.
Takano T, Wallace JT, Baldwin KT, Purkey AM, Uezu A, Courtland JL, Soderblom EJ, Shimogori T, Maness PF, Eroglu C, Soderling SH, et al.
Nature (2020) : . 147 011 WB, ICC; tested species: mouse
Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia.
Park GH, Noh H, Shao Z, Ni P, Qin Y, Liu D, Beaudreault CP, Park JS, Abani CP, Park JM, Le DT, et al.
Nature neuroscience (2020) 2311: 1352-1364. 147 011 ICC; tested species: human
A GTPase-induced switch in phospholipid affinity of collybistin contributes to synaptic gephyrin clustering.
Kilisch M, Mayer S, Mitkovski M, Roehse H, Hentrich J, Schwappach B, Papadopoulos T
Journal of cell science (2020) : . 147 011 ICC; tested species: rat
Poly I:C induced maternal immune challenge reduces perineuronal net area and raises spontaneous network activity of hippocampal neurons in vitro.
Wegrzyn D, Manitz MP, Kostka M, Freund N, Juckel G, Faissner A
The European journal of neuroscience (2020) : . 147 011 ICC; tested species: mouse
Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse.
Crosby KC, Gookin SE, Garcia JD, Hahm KM, Dell'Acqua ML, Smith KR
Cell reports (2019) 2612: 3284-3297.e3. 147 011 ICC, IHC; tested species: rat
Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.
Davenport EC, Szulc BR, Drew J, Taylor J, Morgan T, Higgs NF, López-Doménech G, Kittler JT
Cell reports (2019) 268: 2037-2051.e6. 147 011 WB, ICC, IHC; tested species: mouse
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 147 011 ICC; tested species: mouse
βPix heterozygous mice have defects in neuronal morphology and social interaction.
Kwon Y, Lee SJ, Lee E, Kim D, Park D
Biochemical and biophysical research communications (2019) 5164: 1204-1210. 147 011 ICC; tested species: mouse
SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling.
Halff EF, Szulc BR, Lesept F, Kittler JT
Cell reports (2019) 299: 2599-2607.e6. 147 011 ICC; tested species: rat
HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture.
Hu G, Niu F, Liao K, Periyasamy P, Sil S, Liu J, Dravid SM, Buch S
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2019) : . 147 011 WB, ICC, IHC; tested species: human,rat,monkey
Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.
Gottschling C, Wegrzyn D, Denecke B, Faissner A
Scientific reports (2019) 91: 13939. 147 011 ICC; tested species: mouse
Biallelic DMXL2 mutations impair autophagy and cause Ohtahara syndrome with progressive course.
Esposito A, Falace A, Wagner M, Gal M, Mei D, Conti V, Pisano T, Aprile D, Cerullo MS, De Fusco A, Giovedì S, et al.
Brain : a journal of neurology (2019) : . 147 011 ICC; tested species: mouse
Regulation of dendrite morphology and excitatory synapse formation by zDHHC15.
Shah BS, Shimell JJ, Bamji SX
Journal of cell science (2019) 13213: . 147 011 ICC; tested species: rat
The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
Shimell JJ, Shah BS, Cain SM, Thouta S, Kuhlmann N, Tatarnikov I, Jovellar DB, Brigidi GS, Kass J, Milnerwood AJ, Snutch TP, et al.
Cell reports (2019) 298: 2422-2437.e8. 147 011 WB, ICC; tested species: rat
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.
Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, et al.
Neuron (2019) 1034: 617-626.e6. 147 011 ICC; tested species: human
Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice.
Uezu A, Hisey E, Kobayashi Y, Gao Y, Bradshaw TW, Devlin P, Rodriguiz R, Tata PR, Soderling S
eLife (2019) 8: . 147 011 ICC; tested species: mouse
Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling.
Brady ML, Pilli J, Lorenz-Guertin JM, Das S, Moon CE, Graff N, Jacob TC
Neuropharmacology (2018) 128: 324-339. 147 011 ICC; tested species: rat
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 147 011 ICC; tested species: mouse
Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength.
Ge Y, Kang Y, Cassidy RM, Moon KM, Lewis R, Wong ROL, Foster LJ, Craig AM
Neuron (2018) 973: 596-610.e8. 147 011 ICC, IHC; tested species: mouse
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, et al.
Science (New York, N.Y.) (2018) : . 147 011 ICC; tested species: rat
Prions activate a p38 MAPK synaptotoxic signaling pathway.
Fang C, Wu B, Le NTT, Imberdis T, Mercer RCC, Harris DA
PLoS pathogens (2018) 149: e1007283. 147 011 ICC; tested species: mouse
GARLH Family Proteins Stabilize GABAA Receptors at Synapses.
Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S
Neuron (2017) 935: 1138-1152.e6. 147 011 ICC
Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.
Patrizio A, Renner M, Pizzarelli R, Triller A, Specht CG
Scientific reports (2017) 71: 10899. 147 011 ICC; tested species: rat
Nanoscale Molecular Reorganization of the Inhibitory Postsynaptic Density Is a Determinant of GABAergic Synaptic Potentiation.
Pennacchietti F, Vascon S, Nieus T, Rosillo C, Das S, Tyagarajan SK, Diaspro A, Del Bue A, Petrini EM, Barberis A, Cella Zanacchi F, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 377: 1747-1756. 147 011 ICC
The antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro.
Dzyubenko E, Juckel G, Faissner A
Scientific reports (2017) 71: 11609. 147 011 ICC; tested species: mouse
Adaptive-illumination STED nanoscopy.
Heine J, Reuss M, Harke B, D'Este E, Sahl SJ, Hell SW
Proceedings of the National Academy of Sciences of the United States of America (2017) 11437: 9797-9802. 147 011 ICC; tested species: rat
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Nature chemical biology (2017) 132: 153-160. 147 011 WB, ICC; tested species: mouse
Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability.
Papadopoulos T, Schemm R, Grubmüller H, Brose N
The Journal of biological chemistry (2015) 29013: 8256-70. 147 011 ICC
Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, et al.
Nature communications (2015) 6: 6872. 147 011 ICC
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 147 011 ICC; tested species: rat
Plexin-B3 suppresses excitatory and promotes inhibitory synapse formation in rat hippocampal neurons.
Laht P, Tammaru E, Otsus M, Rohtla J, Tiismus L, Veske A
Experimental cell research (2015) 3352: 269-78. 147 011 ICC
Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5.
Brigidi GS, Santyr B, Shimell J, Jovellar B, Bamji SX
Nature communications (2015) 6: 8200. 147 011 ICC
Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons.
Varea O, Martin-de-Saavedra MD, Kopeikina KJ, Schürmann B, Fleming HJ, Fawcett-Patel JM, Bach A, Jang S, Peles E, Kim E, Penzes P, et al.
Proceedings of the National Academy of Sciences of the United States of America (2015) 11219: 6176-81. 147 011 ICC
A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
Vullhorst D, Mitchell RM, Keating C, Roychowdhury S, Karavanova I, Tao-Cheng JH, Buonanno A
Nature communications (2015) 6: 7222. 147 011 ICC
Proteomic analysis of glycine receptor β subunit (GlyRβ)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors.
Del Pino I, Koch D, Schemm R, Qualmann B, Betz H, Paarmann I
The Journal of biological chemistry (2014) 28916: 11396-409. 147 011 ICC; tested species: rat
Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.
Wang SH, Celic I, Choi SY, Riccomagno M, Wang Q, Sun LO, Mitchell SP, Vasioukhin V, Huganir RL, Kolodkin AL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3438: 12745-61. 147 011 ICC; tested species: mouse
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.
Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, et al.
Nature communications (2014) 5: 3921. 147 011 ICC; tested species: mouse
Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain.
Mishra A, Traut MH, Becker L, Klopstock T, Stein V, Klein R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3412: 4187-99. 147 011 ICC, IHC; tested species: mouse
High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons.
Nieland TJ, Logan DJ, Saulnier J, Lam D, Johnson C, Root DE, Carpenter AE, Sabatini BL
PloS one (2014) 93: e91744. 147 011 ICC; tested species: mouse
Differential control of thrombospondin over synaptic glycine and AMPA receptors in spinal cord neurons.
Hennekinne L, Colasse S, Triller A, Renner M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3328: 11432-9. 147 011 ICC; tested species: rat
Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites.
Specht CG, Izeddin I, Rodriguez PC, El Beheiry M, Rostaing P, Darzacq X, Dahan M, Triller A
Neuron (2013) 792: 308-21. 147 011 ICC; tested species: mouse
TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors.
Pribiag H, Stellwagen D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3340: 15879-93. 147 011 ICC; tested species: rat
Effects of distinct collybistin isoforms on the formation of GABAergic synapses in hippocampal neurons.
Körber C, Richter A, Kaiser M, Schlicksupp A, Mükusch S, Kuner T, Kirsch J, Kuhse J
Molecular and cellular neurosciences (2012) 503-4: 250-9. 147 011 ICC
Tracing synaptic connectivity onto embryonic stem cell-derived neurons.
Garcia I, Huang L, Ung K, Arenkiel BR
Stem cells (Dayton, Ohio) (2012) 3010: 2140-51. 147 011 ICC; tested species: mouse
Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrin.
Tretter V, Kerschner B, Milenkovic I, Ramsden SL, Ramerstorfer J, Saiepour L, Maric HM, Moss SJ, Schindelin H, Harvey RJ, Sieghart W, et al.
The Journal of biological chemistry (2011) 28643: 37702-11. 147 011 ICC; tested species: mouse
Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis.
Hughes EG, Elmariah SB, Balice-Gordon RJ
Molecular and cellular neurosciences (2010) 431: 136-45. 147 011 ICC; tested species: rat
Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy.
Förstera B, Belaidi AA, Jüttner R, Bernert C, Tsokos M, Lehmann TN, Horn P, Dehnicke C, Schwarz G, Meier JC
Brain : a journal of neurology (2010) 133Pt 12: 3778-94. 147 011 ICC
Induction of GABAergic postsynaptic differentiation by alpha-neurexins.
Kang Y, Zhang X, Dobie F, Wu H, Craig AM
The Journal of biological chemistry (2008) 2834: 2323-34. 147 011 ICC; tested species: rat
Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons.
Hartman KN, Pal SK, Burrone J, Murthy VN
Nature neuroscience (2006) 95: 642-9. 147 011 ICC
Structure function and splice site analysis of the synaptogenic activity of the neurexin-1 beta LNS domain.
Graf ER, Kang Y, Hauner AM, Craig AM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2616: 4256-65. 147 011 ICC
Neuronal cotransport of glycine receptor and the scaffold protein gephyrin.
Maas C, Tagnaouti N, Loebrich S, Behrend B, Lappe-Siefke C, Kneussel M
The Journal of cell biology (2006) 1723: 441-51. 147 011 ICC
Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors.
Jacob TC, Bogdanov YD, Magnus C, Saliba RS, Kittler JT, Haydon PG, Moss SJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2005) 2545: 10469-78. 147 011 ICC
A gephyrin-related mechanism restraining glycine receptor anchoring at GABAergic synapses.
Meier J, Grantyn R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2004) 246: 1398-405. 147 011 ICC
GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites.
Rathgeber L, Gromova KV, Schaefer I, Breiden P, Lohr C, Kneussel M
European journal of cell biology () 943-4: 173-8. 147 011 ICC
Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain.
Lorenzo LE, Godin AG, Ferrini F, Bachand K, Plasencia-Fernandez I, Labrecque S, Girard AA, Boudreau D, Kianicka I, Gagnon M, Doyon N, et al.
Nature communications (2020) 111: 869. 147 011 IHC; tested species: rat
Piriform cortex alterations in the Ts65Dn model for down syndrome.
Carbonell J, Blasco-Ibáñez JM, Crespo C, Nácher J, Varea E
Brain research (2020) 1747: 147031. 147 011 IHC; tested species: mouse
Neurotransmitters and motoneuron contacts of multifunctional and behaviorally specialized turtle spinal cord interneurons.
Bannatyne BA, Hao 郝赵哲 ZZ, Dyer GMC, Watanabe M, Maxwell DJ, Berkowitz A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 147 011 IHC
Glutamate transporter 1-expressing glia in the rat substantia nigra-Morphometric analysis and relationships to synapses.
Kessler JP, Salin P, Kerkerian-Le Goff L
Glia (2020) : . 147 011 IHC; tested species: rat
Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants.
Fazel Darbandi S, Robinson Schwartz SE, Pai EL, Everitt A, Turner ML, Cheyette BNR, Willsey AJ, State MW, Sohal VS, Rubenstein JLR
Cell reports (2020) 312: 107495. 147 011 IHC; tested species: mouse
Dynamics of the Fragile X Mental Retardation Protein Correlates with Cellular and Synaptic Properties in Primary Auditory Neurons following Afferent Deprivation.
Yu X, Wang X, Sakano H, Zorio DAR, Wang Y
The Journal of comparative neurology (2020) : . 147 011 IHC; tested species: chicken
Semilunar granule cells are the primary source of the perisomatic excitatory innervation onto parvalbumin-expressing interneurons in the dentate gyrus.
Rovira-Esteban L, Hájos N, Nagy GA, Crespo C, Nacher J, Varea E, Blasco-Ibáñez JM
eNeuro (2020) : . 147 011 IHC; tested species: mouse
SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury.
Sauerbeck AD, Gangolli M, Reitz SJ, Salyards MH, Kim SH, Hemingway C, Gratuze M, Makkapati T, Kerschensteiner M, Holtzman DM, Brody DL, et al.
Neuron (2020) 1072: 257-273.e5. 147 011 IHC; tested species: mouse
Role of endocannabinoid signaling in a septohabenular pathway in the regulation of anxiety- and depressive-like behavior.
Vickstrom CR, Liu X, Liu S, Hu MM, Mu L, Hu Y, Yu H, Love SL, Hillard CJ, Liu QS
Molecular psychiatry (2020) : . 147 011 IHC; tested species: mouse
Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model.
Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG
Scientific reports (2020) 101: 19606. 147 011 WB, IHC; tested species: mouse
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease.
Richetin K, Steullet P, Pachoud M, Perbet R, Parietti E, Maheswaran M, Eddarkaoui S, Bégard S, Pythoud C, Rey M, Caillierez R, et al.
Nature neuroscience (2020) 2312: 1567-1579. 147 011 IHC; tested species: mouse
Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits.
Exposito-Alonso D, Osório C, Bernard C, Pascual-García S, Del Pino I, Marín O, Rico B
eLife (2020) 9: . 147 011 IHC; tested species: mouse
HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture.
Hu G, Niu F, Liao K, Periyasamy P, Sil S, Liu J, Dravid SM, Buch S
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2019) : . 147 011 WB, ICC, IHC; tested species: human,rat,monkey
Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex.
Kroon T, van Hugte E, van Linge L, Mansvelder HD, Meredith RM
Scientific reports (2019) 91: 5037. 147 011 IHC; tested species: mouse
Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse.
Crosby KC, Gookin SE, Garcia JD, Hahm KM, Dell'Acqua ML, Smith KR
Cell reports (2019) 2612: 3284-3297.e3. 147 011 ICC, IHC; tested species: rat
Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
Hu HY, Kruijssen DLH, Frias CP, Rózsa B, Hoogenraad CC, Wierenga CJ
Cell reports (2019) 273: 666-675.e5. 147 011 IHC; tested species: mouse
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.
Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, et al.
Nature neuroscience (2019) : . 147 011 IHC; tested species: human,mouse
Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch.
Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, Eva C, Goulding M
Cell reports (2019) 283: 625-639.e6. 147 011 IHC; tested species: mouse
Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation.
Frias CP, Liang J, Bresser T, Scheefhals L, van Kesteren M, van Dorland R, Hu HY, Bodzeta A, van Bergen En Henegouwen PMP, Hoogenraad CC, Wierenga CJ, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3922: 4221-4237. 147 011 IHC; tested species: mouse
Long-Lasting Rescue of Network and Cognitive Dysfunction in a Genetic Schizophrenia Model.
Mukherjee A, Carvalho F, Eliez S, Caroni P
Cell (2019) 1786: 1387-1402.e14. 147 011 IHC; tested species: mouse
Disturbed prefrontal cortex activity in the absence of schizophrenia-like behavioral dysfunction in Arc/Arg3.1 deficient mice.
Gao X, Grendel J, Muhia M, Castro-Gomez S, Süsens U, Isbrandt D, Kneussel M, Kuhl D, Ohana O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 147 011 IHC; tested species: mouse
Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.
Fossati M, Assendorp N, Gemin O, Colasse S, Dingli F, Arras G, Loew D, Charrier C
Neuron (2019) : . 147 011 IHC; tested species: mouse
Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis.
Hollnagel JO, Elzoheiry S, Gorgas K, Kins S, Beretta CA, Kirsch J, Kuhse J, Kann O, Kiss E
PloS one (2019) 141: e0209228. 147 011 IHC; tested species: mouse
Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.
Davenport EC, Szulc BR, Drew J, Taylor J, Morgan T, Higgs NF, López-Doménech G, Kittler JT
Cell reports (2019) 268: 2037-2051.e6. 147 011 WB, ICC, IHC; tested species: mouse
Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions.
Meng X, McGraw CM, Wang W, Jing J, Yeh SY, Wang L, Lopez J, Brown AM, Lin T, Chen W, Xue M, et al.
eLife (2019) 8: . 147 011 IHC; tested species: mouse
Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM.
Tai Y, Gallo NB, Wang M, Yu JR, Van Aelst L
Neuron (2019) : . 147 011 IHC; tested species: mouse
Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity.
Fazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, et al.
Neuron (2018) 1004: 831-845.e7. 147 011 IHC; tested species: mouse
Regulation of Synapse Development by Vgat Deletion from ErbB4-Positive Interneurons.
Lin TW, Tan Z, Barik A, Yin DM, Brudvik E, Wang H, Xiong WC, Mei L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3810: 2533-2550. 147 011 IHC; tested species: mouse
Developmental pattern and structural factors of dendritic survival in cerebellar granule cells in vivo.
Dhar M, Hantman AW, Nishiyama H
Scientific reports (2018) 81: 17561. 147 011 IHC; tested species: mouse
Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength.
Ge Y, Kang Y, Cassidy RM, Moon KM, Lewis R, Wong ROL, Foster LJ, Craig AM
Neuron (2018) 973: 596-610.e8. 147 011 ICC, IHC; tested species: mouse
Long-lasting effects of early-life intervention in mice on adulthood behaviour, GABAA receptor subunit expression and synaptic clustering.
Skilbeck KJ, Johnston GAR, Hinton T
Pharmacological research (2018) 128: 179-189. 147 011 IHC; tested species: mouse
GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.
Jiang DY, Wu Z, Forsyth CT, Hu Y, Yee SP, Chen G
Molecular brain (2018) 111: 31. 147 011 IHC; tested species: mouse
Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons.
Wamsley B, Jaglin XH, Favuzzi E, Quattrocolo G, Nigro MJ, Yusuf N, Khodadadi-Jamayran A, Rudy B, Fishell G
Neuron (2018) : . 147 011 IHC; tested species: mouse
Postsynaptic FMRP regulates synaptogenesis in vivo in the developing cochlear nucleus.
Wang X, Zorio DAR, Schecterson L, Lu Y, Wang Y
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 147 011 IHC; tested species: chicken
Synaptic distribution of individually labeled mitral cells in the external plexiform layer of the mouse olfactory bulb.
Matsuno T, Kiyokage E, Toida K
The Journal of comparative neurology (2017) 5257: 1633-1648. 147 011 IHC; tested species: mouse
The excitatory/inhibitory input to orexin/hypocretin neuron soma undergoes day/night reorganization.
Laperchia C, Imperatore R, Azeez IA, Del Gallo F, Bertini G, Grassi-Zucconi G, Cristino L, Bentivoglio M
Brain structure & function (2017) 2228: 3847-3859. 147 011 IHC; tested species: mouse
Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.
Favuzzi E, Marques-Smith A, Deogracias R, Winterflood CM, Sánchez-Aguilera A, Mantoan L, Maeso P, Fernandes C, Ewers H, Rico B
Neuron (2017) 953: 639-655.e10. 147 011 IHC; tested species: mouse
Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state.
Fuchs T, Jefferson SJ, Hooper A, Yee PH, Maguire J, Luscher B
Molecular psychiatry (2017) 226: 920-930. 147 011 IHC
Iterative expansion microscopy.
Chang JB, Chen F, Yoon YG, Jung EE, Babcock H, Kang JS, Asano S, Suk HJ, Pak N, Tillberg PW, Wassie AT, et al.
Nature methods (2017) 146: 593-599. 147 011 IHC; tested species: mouse
Differential role of GABAA receptors and neuroligin 2 for perisomatic GABAergic synapse formation in the hippocampus.
Panzanelli P, Früh S, Fritschy JM
Brain structure & function (2017) 2229: 4149-4161. 147 011 IHC; tested species: mouse
Enrichment of GABAA Receptor α-Subunits on the Axonal Initial Segment Shows Regional Differences.
Gao Y, Heldt SA
Frontiers in cellular neuroscience (2016) 10: 39. 147 011 IHC
Recurrent Inhibition to the Medial Nucleus of the Trapezoid Body in the Mongolian Gerbil (Meriones Unguiculatus).
Dondzillo A, Thompson JA, Klug A
PloS one (2016) 118: e0160241. 147 011 IHC
Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer.
Bartel DL, Rela L, Hsieh L, Greer CA
The Journal of comparative neurology (2015) 5238: 1145-61. 147 011 IHC
Interneuron- and GABA(A) receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells.
He Q, Duguid I, Clark B, Panzanelli P, Patel B, Thomas P, Fritschy JM, Smart TG
Nature communications (2015) 6: 7364. 147 011 IHC
Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb.
Deprez F, Pallotto M, Vogt F, Grabiec M, Virtanen MA, Tyagarajan SK, Panzanelli P, Fritschy JM
The Journal of comparative neurology (2015) 52313: 1998-2016. 147 011 IHC, EM
A unique ion channel clustering domain on the axon initial segment of mammalian neurons.
King AN, Manning CF, Trimmer JS
The Journal of comparative neurology (2014) 52211: 2594-608. 147 011 IHC; tested species: rat
Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain.
Mishra A, Traut MH, Becker L, Klopstock T, Stein V, Klein R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3412: 4187-99. 147 011 ICC, IHC; tested species: mouse
Gephyrin clusters are absent from small diameter primary afferent terminals despite the presence of GABA(A) receptors.
Lorenzo LE, Godin AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De Koninck Y
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3424: 8300-17. 147 011 IHC; tested species: rat
Spatial relationships between GABAergic and glutamatergic synapses on the dendrites of distinct types of mouse retinal ganglion cells across development.
Bleckert A, Parker ED, Kang Y, Pancaroglu R, Soto F, Lewis R, Craig AM, Wong RO
PloS one (2013) 87: e69612. 147 011 IHC; tested species: mouse
Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse.
Hruskova B, Trojanova J, Kulik A, Kralikova M, Pysanenko K, Bures Z, Syka J, Trussell LO, Turecek R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3247: 17012-24. 147 011 IHC, EM
Distribution of gephyrin-immunoreactivity in the trigeminal motor nucleus: an immunohistochemical study in rats.
Li Z, Ge S, Zhang F, Zhang T, Mizuno N, Hioki H, Kaneko T, Gao G, Li J
Anatomical record (Hoboken, N.J. : 2007) (2012) 2954: 641-51. 147 011 IHC, EM; tested species: rat
Somatostatin varicosities contain the vesicular GABA transporter and contact orexin neurons in the hypothalamus.
Toossi H, Del Cid-Pellitero E, Stroh T, Jones BE
The European journal of neuroscience (2012) 3610: 3388-95. 147 011 IHC
Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.
Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM
The Journal of physiology (2011) 589Pt 20: 4959-80. 147 011 IHC, EM; tested species: mouse
Quantitative study of NPY-expressing GABAergic neurons and axons in rat spinal dorsal horn.
Polgár E, Sardella TC, Watanabe M, Todd AJ
The Journal of comparative neurology (2011) 5196: 1007-23. 147 011 IHC; tested species: rat
Mixed GABA-glycine synapses delineate a specific topography in the nucleus tractus solitarii of adult rat.
Dufour A, Tell F, Kessler JP, Baude A
The Journal of physiology (2010) 588Pt 7: 1097-115. 147 011 IHC; tested species: rat
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome.
Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC
The Journal of comparative neurology (2009) 5124: 453-66. 147 011 IHC; tested species: mouse
Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones.
Peden DR, Petitjean CM, Herd MB, Durakoglugil MS, Rosahl TW, Wafford K, Homanics GE, Belelli D, Fritschy JM, Lambert JJ
The Journal of physiology (2008) 5864: 965-87. 147 011 IHC; tested species: mouse
Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of gamma-aminobutyric acid type A receptor alpha1 subunit knockout mice.
Kralic JE, Sidler C, Parpan F, Homanics GE, Morrow AL, Fritschy JM
The Journal of comparative neurology (2006) 4954: 408-21. 147 011 IHC
Synaptic destabilization by neuronal Nogo-A.
Aloy EM, Weinmann O, Pot C, Kasper H, Dodd DA, Rülicke T, Rossi F, Schwab ME
Brain cell biology (2006) 352-3: 137-56. 147 011 IHC
Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin.
Grady RM, Wozniak DF, Ohlemiller KK, Sanes JR
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2611: 2841-51. 147 011 IHC
Immunofluorescence in brain sections: simultaneous detection of presynaptic and postsynaptic proteins in identified neurons.
Schneider Gasser EM, Straub CJ, Panzanelli P, Weinmann O, Sassoè-Pognetto M, Fritschy JM
Nature protocols (2006) 14: 1887-97. 147 011 IHC
Neurochemical anatomy of the zebrafish retina as determined by immunocytochemistry.
Yazulla S, Studholme KM
Journal of neurocytology (2001) 307: 551-92. 147 011 IHC; tested species: zebrafish
Glycinergic miniature synaptic currents and receptor cluster sizes differ between spinal cord interneurons.
Oleskevich S, Alvarez FJ, Walmsley B
Journal of neurophysiology (1999) 821: 312-9. 147 011 IHC
Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity.
Feng G, Tintrup H, Kirsch J, Nichol MC, Kuhse J, Betz H, Sanes JR
Science (New York, N.Y.) (1998) 2825392: 1321-4. 147 011 IHC; KO verified; tested species: mouse
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.
Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, et al.
Nature (2020) : . 147 011 IHC-P; tested species: mouse
Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb.
Deprez F, Pallotto M, Vogt F, Grabiec M, Virtanen MA, Tyagarajan SK, Panzanelli P, Fritschy JM
The Journal of comparative neurology (2015) 52313: 1998-2016. 147 011 IHC, EM
Distribution of gephyrin-immunoreactivity in the trigeminal motor nucleus: an immunohistochemical study in rats.
Li Z, Ge S, Zhang F, Zhang T, Mizuno N, Hioki H, Kaneko T, Gao G, Li J
Anatomical record (Hoboken, N.J. : 2007) (2012) 2954: 641-51. 147 011 IHC, EM; tested species: rat
Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse.
Hruskova B, Trojanova J, Kulik A, Kralikova M, Pysanenko K, Bures Z, Syka J, Trussell LO, Turecek R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3247: 17012-24. 147 011 IHC, EM
Synaptic reorganization in the adult rat's ventral cochlear nucleus following its total sensory deafferentation.
Hildebrandt H, Hoffmann NA, Illing RB
PloS one (2011) 68: e23686. 147 011 EM; tested species: rat
Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.
Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM
The Journal of physiology (2011) 589Pt 20: 4959-80. 147 011 IHC, EM; tested species: mouse
Monoclonal antibodies and peptide mapping reveal structural similarities between the subunits of the glycine receptor of rat spinal cord.
Pfeiffer F, Simler R, Grenningloh G, Betz H
Proceedings of the National Academy of Sciences of the United States of America (1984) 8122: 7224-7. 147 011
ICC
ICC
IHC
Background

Gephyrin is a bifunctional protein which is essential for both synaptic clustering of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor (MoCo) in peripheral tissues. It co-purifies with the inhibitory glycine receptor (GlyR) and is expressed abundantly in all brain areas which contain synapses.
Other products for this target