Cat. No.: 135 421AbRED
Amount: 100 µg
Price:
$470.00
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| Cat. No. 135 421AbRED |
100 µg purified IgG, lyophilized, fluorescence-labeled with
abberior STAR RED.
Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Either add 1:1 (v/v) glycerol, then aliquot and store at -20°C until use, or store aliquots at -80°C without additives. Reconstitute immediately upon receipt! Avoid bright light when working with the antibody to minimize photo bleeching of the fluorescent dye. |
| Applications | |
| Label | abberior STAR RED |
| Clone | 95E11 |
| Subtype | IgG2a (κ light chain) |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of rat VGLUT2 (UniProt Id: Q9JI12) |
| Reactivity |
Reacts with: mouse (Q8BLE7), rat (Q9JI12). Other species not tested yet. |
| Remarks |
ICC: This antibody conjugate is especially suitable for high resolution STED-microscopy. |
| Data sheet | 135_421abred.pdf |
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The vesicular glutamate transporter 2 VGLUT2, also referred to as DNPI and SLC17A6, has a more restricted expression than the related VGLUT1. Like VGLUT1, it is both necessary and sufficient for uptake and storage of glutamate and thus comprises the sole determinant for a glutamatergic phenotype. Both VGLUTs are different from the plasma membrane transporters in that they are driven by a proton electrochemical gradient across the vesicle membrane.
VGLUT1 and VGLUT2 show complementary expression patterns. Together, they are currently the best markers for glutamatergic nerve terminals and glutamatergic synapses.