Cat. No.: 129 321
Amount: 100 µg
Price:
$415.00
|
|
|
| Cat. No. 129 321 |
100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | SY-112A8 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of mouse Neuroligin 3 (UniProt Id: Q8BYM5) |
| Reactivity |
Reacts with: mouse (Q8BYM5), rat (Q62889). Other species not tested yet. |
| Specificity | K.O. validated |
| Data sheet | 129_321.pdf |
|
|
Neuroligins form a family of postsynaptic cell surface molecules that interact with β-neurexins. They are 110-120 kDa polypeptides with homology to acetylcholine esterase. Neuroligin 1 and neuroligin 3 are specifically localized to post-synaptic densities of excitatory synapses whereas neuroligin 2 is found exclusively on inhibitory synapses.
Mutations in neuroligin 3 and neuroligin 4 have been implicated with a rare, heritable form of autism.