Cat. No.: 129 308
Amount: 50 µg
Price:
$415.00
|
|
|
| Cat. No. 129 308 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Rb112A8 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of mouse Neuroligin3 (UniProt Id: Q8BYM5) |
| Reactivity |
Reacts with: mouse (Q8BYM5), rat. Other species not tested yet. |
| Specificity | K.O. validated |
| Matching control protein/peptide | 129-3P |
| Remarks |
This antibody is a chimeric antibody based on the monoclonal mouse antibody SY-112A8. The constant regions of the heavy and light chains have been replaced with rabbit specific sequences. The antibody can therefore be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 129_308.pdf |
|
|
Neuroligins form a family of post-synaptic cell surface molecules that interact with β-neurexins. They are 110-120 kDa polypeptides with homology to acetylcholine esterase. Neuroligin1 and neuroligin3 are specifically localized to post-synaptic densities of excitatory synapses whereas neuroligin2 is found exclusively on inhibitory synapses.
Mutations in neuroligin3 and neuroligin4 have been implicated with a rare, heritable form of autism.