Cat. No.: 110 318
Amount: 50 µg
Price:
$415.00
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| Cat. No. 110 318 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Gp78.3 |
| Subtype | IgG2 (κ light chain) |
| Immunogen | Recombinant protein corresponding to cytoplasmic-domain without membrane anchor of rat Syntaxin 1A. (UniProt Id: P32851) |
| Reactivity |
Reacts with: human (Q16623), rat (P32851), mouse (O35526), mammals, chicken. Other species not tested yet. |
| Specificity | Specific für syntaxin 1A, no cross-reactivity to syntaxin 1B. K.O. validated |
| Matching control protein/peptide | 110-1P |
| Remarks |
This antibody is a chimeric antibody based on the monoclonal mouse antibody clone 78.3. The constant regions of the heavy and light chains have been replaced by guinea pig specific sequences. Therefore, the antibody can be used with standard anti-guinea pig secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 110_318.pdf |
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Syntaxin 1, also known as p35, is a small integral membrane protein that is abundantly expressed in neurons and neuroendocrine cells. It was initially discovered as HPC-1. Syntaxin 1 is an essential component of the exocytotic fusion machine and interacts with several other proteins important for synaptic function, including its partners in the fusion complex synaptobrevin, SNAP 25, α-SNAP, synaptotagmin 1, Munc 18/n-Sec1 and Ca2+-channels.
Syntaxin 1 is localized primarily to the neuronal plasmalemma and is concentrated in synapses where pools of the protein are also present on recycling organelles including synaptic vesicles. It is the main target of one of the Botulinum neurotoxins BoNT/C1 which, however, cannot cleave the protein when complexed with its partner proteins in the fusion complex.