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Home > Products > 104 202

Synaptobrevin2 antibody - 104 202 K.O.

Synaptobrevin 2 also known as Vamp 2 is a major vesicle protein involved in fusion
Rabbit polyclonal antiserum
Cat. No.: 104 202
Amount: 200 µl
Price: $355.00
Cat. No. 104 202 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 up to 1 : 10000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 up to 1 : 2000 gallery  
IHC: 1 : 500 up to 1 : 2000 gallery  
IHC-P: 1 : 1000 gallery  
ExM: yes
EM: yes
Immunogen Synthetic peptide corresponding to residues near the amino terminus of rat Synaptobrevin2 (UniProt Id: P63045)
Reactivity Reacts with: human (P63027), rat (P63045), mouse (P63044), hamster.
No signal: chicken, zebrafish.
Other species not tested yet.
Specificity K.O. validated PubMed: 36148511
Remarks

This antibody recognizes the Botulinumtoxin B cleavage product (aa 1 - 76) with reduced affinity. The sensitivity is sufficient for the detection of cleaved recombinant protein.For analysis of toxin treated tissue homogenates cat. no. 104 203 is recommended.
Data sheet 104_202.pdf

References for Synaptobrevin2 - 104 202

Endoplasmic reticulum stress impedes regulated secretion by governing key exocytotic and granulogenic molecular switches.
Mukherjee M, Mukherjee C, Ghosh V, Jain A, Sadhukhan S, Dagar S, Sahu BS
Journal of cell science (2024) 1376: . 104 202 WB; tested species: rat
Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology.
Bian X, Zhu J, Jia X, Liang W, Yu S, Li Z, Zhang W, Rao Y
eLife (2023) 12: . 104 202 WB; tested species: mouse
The proteomic landscape of synaptic diversity across brain regions and cell types.
van Oostrum M, Blok TM, Giandomenico SL, Tom Dieck S, Tushev G, Fürst N, Langer JD, Schuman EM
Cell (2023) 18624: 5411-5427.e23. 104 202 WB; tested species: mouse
Ca2+ -independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons.
Wang Y, Huang R, Chai Z, Wang C, Du X, Hang Y, Xu Y, Li J, Jiang X, Wu X, Qiao Z, et al.
EMBO reports (2022) : e54507. 104 202 WB; KO verified; tested species: mouse
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.
Xie YX, Naseri NN, Fels J, Kharel P, Na Y, Lane D, Burré J, Sharma M
Nature communications (2022) 131: 4918. 104 202 WB; tested species: mouse
Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.
Schwab K, Chasapopoulou Z, Frahm S, Magbagbeolu M, Cranston A, Harrington CR, Wischik CM, Theuring F, Riedel G
Cellular signalling (2022) 97: 110386. 104 202 WB; tested species: mouse
Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.
Dolai S, Takahashi T, Qin T, Liang T, Xie L, Kang F, Miao YF, Xie H, Kang Y, Manuel J, Winter E, et al.
Autophagy (2020) : 1-14. 104 202 WB; tested species: human
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, et al.
Cell systems (2020) : . 104 202 WB, IHC; tested species: mouse
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 104 202 WB; tested species: mouse
Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes.
Morris S, Geoghegan ND, Sadler JBA, Koester AM, Black HL, Laub M, Miller L, Heffernan L, Simpson JC, Mastick CC, Cooper J, et al.
PeerJ (2020) 8: e8751. 104 202 WB; KD verified; tested species: mouse
Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.
Santa-Marinha L, Castanho I, Silva RR, Bravo FV, Miranda AM, Meira T, Morais-Ribeiro R, Marques F, Xu Y, Point du Jour K, Wenk M, et al.
Cell reports (2020) 3012: 4197-4208.e6. 104 202 WB; tested species: mouse
Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission.
Jäpel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V
Cell reports (2020) 302: 409-420.e6. 104 202 WB; tested species: mouse
Merlin modulates process outgrowth and synaptogenesis in the cerebellum.
Toledo A, Lang F, Doengi M, Morrison H, Stein V, Baader SL
Brain structure & function (2019) : . 104 202 WB; tested species: mouse
Cardiac SNARE Expression in Health and Disease.
Bowman PRT, Smith GL, Gould GW
Frontiers in endocrinology (2019) 10: 881. 104 202 WB; tested species: mouse
Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.
Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, et al.
Molecular neurodegeneration (2019) 141: 43. 104 202 WB; tested species: mouse
Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage.
Yao W, Tambini MD, Liu X, D'Adamio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 104 202 WB; tested species: mouse
Age-related cognitive impairment: Role of reduced synaptobrevin-2 levels in memory and synaptic plasticity deficits.
Orock A, Logan S, Deak F
The journals of gerontology. Series A, Biological sciences and medical sciences (2019) : . 104 202 WB; KD verified; tested species: mouse
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, et al.
Science (New York, N.Y.) (2018) : . 104 202 WB; tested species: rat
α2δ-4 is required for the molecular and structural organization of rod and cone photoreceptor synapses.
Kerov V, Laird JG, Joiner ML, Knecht S, Soh D, Hagen J, Gardner SH, Gutierrez W, Yoshimatsu T, Bhattarai S, Puthussery T, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 104 202 WB; tested species: mouse
Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS
Cell (2018) 1724: 706-718.e15. 104 202 WB, ICC; tested species: mouse
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A, et al.
EMBO molecular medicine (2017) 91: 112-132. 104 202 WB, ICC; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 104 202 WB
BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.
Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ
The Journal of cell biology (2017) 2167: 2151-2166. 104 202 WB; tested species: bon cells
Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway.
Sheehan P, Zhu M, Beskow A, Vollmer C, Waites CL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3633: 8668-86. 104 202 WB; tested species: rat
PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.
Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni RI, Prestigio C, Giovedì S, Onofri F, Mura E, Guarnieri FC, et al.
Cell reports (2016) 151: 117-31. 104 202 WB
Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.
Rajappa R, Gauthier-Kemper A, Böning D, Hüve J, Klingauf J
Cell reports (2016) 146: 1369-1381. 104 202 ICC, WB; tested species: rat
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.
Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D
Nature communications (2015) 6: 7314. 104 202 WB; tested species: human
Characterization of VAMP isoforms in 3T3-L1 adipocytes: implications for GLUT4 trafficking.
Sadler JB, Bryant NJ, Gould GW
Molecular biology of the cell (2015) 263: 530-6. 104 202 WB
Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth.
Ulloa F, Gonzàlez-Juncà A, Meffre D, Barrecheguren PJ, Martínez-Mármol R, Pazos I, Olivé N, Cotrufo T, Seoane J, Soriano E
PloS one (2015) 103: e0119707. 104 202 WB
Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.
Beccano-Kelly DA, Kuhlmann N, Tatarnikov I, Volta M, Munsie LN, Chou P, Cao LP, Han H, Tapia L, Farrer MJ, Milnerwood AJ, et al.
Frontiers in cellular neuroscience (2014) 8: 301. 104 202 WB; tested species: mouse
Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J
Neuroscience (2014) 266: 102-15. 104 202 IHC, WB
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.
Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D
The Journal of biological chemistry (2013) 2889: 6371-85. 104 202 WB; tested species: rat
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.
Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff SC, Lorentz A
European journal of immunology (2008) 383: 855-63. 104 202 WB; tested species: human,rat
Differential distribution of vesicle associated membrane protein isoforms in the mouse retina.
Sherry DM, Wang MM, Frishman LJ
Molecular vision (2003) 9: 673-88. 104 202 WB, IHC
S-SCAM is essential for synapse formation.
Wittenmayer N, Petkova-Tuffy A, Borgmeyer M, Lee C, Becker J, Böning A, Kügler S, Rhee J, Viotti JS, Dresbach T
Frontiers in cellular neuroscience (2023) 17: 1182493. 104 202 ICC; tested species: rat
Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia.
Johnston JL, Reda SM, Setti SE, Taylor RW, Berthiaume AA, Walker WE, Wu W, Moebius HJ, Church KJ
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2022) : . 104 202 ICC; tested species: rat
A Super-Resolved View of the Alzheimer's Disease-Related Amyloidogenic Pathway in Hippocampal Neurons.
Yu Y, Gao Y, Winblad B, Tjernberg LO, Schedin-Weiss S
Journal of Alzheimer's disease : JAD (2021) 832: 833-852. 104 202 ICC; tested species: mouse
CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice.
Halperin D, Stavsky A, Kadir R, Drabkin M, Wormser O, Yogev Y, Dolgin V, Proskorovski-Ohayon R, Perez Y, Nudelman H, Stoler O, et al.
Nature communications (2021) 121: 6187. 104 202 ICC; tested species: mouse
Baseline immunoreactivity before pregnancy and poly(I:C) dose combine to dictate susceptibility and resilience of offspring to maternal immune activation.
Estes ML, Prendergast K, MacMahon JA, Cameron S, Paul Aboubechara J, Farrelly K, Sell GL, Haapanen L, Schauer JD, Horta A, Shaffer IC, et al.
Brain, behavior, and immunity (2020) 88: 619-630. 104 202 ICC; tested species: mouse
Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates.
Jiang H, Esparza TJ, Kummer TT, Zhong H, Rettig J, Brody DL
Scientific reports (2020) 101: 3412. 104 202 ICC; tested species: mouse
Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice.
Hoffmann-Conaway S, Brockmann MM, Schneider K, Annamneedi A, Rahman KA, Bruns C, Textoris-Taube K, Trimbuch T, Smalla KH, Rosenmund C, Gundelfinger ED, et al.
eLife (2020) 9: . 104 202 ICC; tested species: mouse
Syntaxins on granules promote docking of granules via interactions with munc18.
Borisovska M
Scientific reports (2018) 81: 193. 104 202 ICC
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.
Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, et al.
Nature communications (2018) 91: 712. 104 202 ICC; tested species: rat
Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS
Cell (2018) 1724: 706-718.e15. 104 202 WB, ICC; tested species: mouse
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
The EMBO journal (2018) : . 104 202 ICC; tested species: rat
The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T
Scientific reports (2017) 71: 15791. 104 202 ICC; tested species: rat
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A, et al.
EMBO molecular medicine (2017) 91: 112-132. 104 202 WB, ICC; tested species: mouse
Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse.
Tagliatti E, Fadda M, Falace A, Benfenati F, Fassio A
eLife (2016) 5: . 104 202 ICC; tested species: rat
Botulinum neurotoxin type-A enters a non-recycling pool of synaptic vesicles.
Harper CB, Papadopulos A, Martin S, Matthews DR, Morgan GP, Nguyen TH, Wang T, Nair D, Choquet D, Meunier FA
Scientific reports (2016) 6: 19654. 104 202 ICC
Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.
Rajappa R, Gauthier-Kemper A, Böning D, Hüve J, Klingauf J
Cell reports (2016) 146: 1369-1381. 104 202 ICC, WB; tested species: rat
Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
Verstegen AM, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, Corradi A, Valtorta F, Gitler D, Onofri F, Fassio A, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3421: 7266-80. 104 202 ICC; tested species: mouse
Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals.
Orenbuch A, Shalev L, Marra V, Sinai I, Lavy Y, Kahn J, Burden JJ, Staras K, Gitler D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3212: 3969-80. 104 202 ICC
Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations.
Adaikkan C, Joseph J, Foustoukos G, Wang J, Polygalov D, Boehringer R, Middleton SJ, Huang AJY, Tsai LH, McHugh TJ
Nature communications (2024) 151: 2190. 104 202 IHC; tested species: mouse
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors.
Schwab K, Lauer D, Magbagbeolu M, Theuring F, Gasiorowska A, Zadrozny M, Harrington CR, Wischik CM, Niewiadomska G, Riedel G
Brain research bulletin (2024) : 110955. 104 202 IHC; tested species: mouse
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, et al.
Cell systems (2020) : . 104 202 WB, IHC; tested species: mouse
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.
Wegrzynowicz M, Bar-On D, Calo' L, Anichtchik O, Iovino M, Xia J, Ryazanov S, Leonov A, Giese A, Dalley JW, Griesinger C, et al.
Acta neuropathologica (2019) : . 104 202 IHC; tested species: mouse
Adult-born neurons facilitate olfactory bulb pattern separation during task engagement.
Li WL, Chu MW, Wu A, Suzuki Y, Imayoshi I, Komiyama T
eLife (2018) 7: . 104 202 IHC; tested species: mouse
Identification of Serotonergic Neuronal Modules that Affect Aggressive Behavior.
Niederkofler V, Asher TE, Okaty BW, Rood BD, Narayan A, Hwa LS, Beck SG, Miczek KA, Dymecki SM
Cell reports (2016) 178: 1934-1949. 104 202 IHC; tested species: mouse
Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy.
Ferecskó AS, Jiruska P, Foss L, Powell AD, Chang WC, Sik A, Jefferys JG
Brain structure & function (2015) 2202: 1013-29. 104 202 IHC
Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning.
Sakamoto M, Ieki N, Miyoshi G, Mochimaru D, Miyachi H, Imura T, Yamaguchi M, Fishell G, Mori K, Kageyama R, Imayoshi I, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3417: 5788-99. 104 202 IHC; tested species: mouse
Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J
Neuroscience (2014) 266: 102-15. 104 202 IHC, WB
MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.
Larimore J, Ryder PV, Kim KY, Ambrose LA, Chapleau C, Calfa G, Gross C, Bassell GJ, Pozzo-Miller L, Smith Y, Talbot K, et al.
PloS one (2013) 86: e65069. 104 202 IHC; tested species: mouse
Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion.
Nakashiba T, Cushman JD, Pelkey KA, Renaudineau S, Buhl DL, McHugh TJ, Rodriguez Barrera V, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, et al.
Cell (2012) 1491: 188-201. 104 202 IHC; tested species: mouse
Differential distribution of vesicle associated membrane protein isoforms in the mouse retina.
Sherry DM, Wang MM, Frishman LJ
Molecular vision (2003) 9: 673-88. 104 202 WB, IHC
Enhanced synaptic protein visualization by multicolor super-resolution expansion microscopy.
Eilts J, Reinhard S, Michetschläger N, Werner C, Sauer M
Neurophotonics (2023) 104: 044412. 104 202 ExM; tested species: mouse
Spatial proteomics in neurons at single-protein resolution.
Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, et al.
Cell (2024) 1877: 1785-1800.e16. 104 202 DNA-PAINT; tested species: rat
A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation.
Oorschot V, de Wit H, Annaert WG, Klumperman J
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (2002) 508: 1067-80. 104 202 EM
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 104 202 ELISA
Cat. No.: 104 202
Amount: 200 µl
Price: $355.00
Endoplasmic reticulum stress impedes regulated secretion by governing key exocytotic and granulogenic molecular switches.
Mukherjee M, Mukherjee C, Ghosh V, Jain A, Sadhukhan S, Dagar S, Sahu BS
Journal of cell science (2024) 1376: . 104 202 WB; tested species: rat
Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology.
Bian X, Zhu J, Jia X, Liang W, Yu S, Li Z, Zhang W, Rao Y
eLife (2023) 12: . 104 202 WB; tested species: mouse
The proteomic landscape of synaptic diversity across brain regions and cell types.
van Oostrum M, Blok TM, Giandomenico SL, Tom Dieck S, Tushev G, Fürst N, Langer JD, Schuman EM
Cell (2023) 18624: 5411-5427.e23. 104 202 WB; tested species: mouse
Ca2+ -independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons.
Wang Y, Huang R, Chai Z, Wang C, Du X, Hang Y, Xu Y, Li J, Jiang X, Wu X, Qiao Z, et al.
EMBO reports (2022) : e54507. 104 202 WB; KO verified; tested species: mouse
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.
Xie YX, Naseri NN, Fels J, Kharel P, Na Y, Lane D, Burré J, Sharma M
Nature communications (2022) 131: 4918. 104 202 WB; tested species: mouse
Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.
Schwab K, Chasapopoulou Z, Frahm S, Magbagbeolu M, Cranston A, Harrington CR, Wischik CM, Theuring F, Riedel G
Cellular signalling (2022) 97: 110386. 104 202 WB; tested species: mouse
Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.
Dolai S, Takahashi T, Qin T, Liang T, Xie L, Kang F, Miao YF, Xie H, Kang Y, Manuel J, Winter E, et al.
Autophagy (2020) : 1-14. 104 202 WB; tested species: human
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, et al.
Cell systems (2020) : . 104 202 WB, IHC; tested species: mouse
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS
Cell reports (2020) 3110: 107712. 104 202 WB; tested species: mouse
Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes.
Morris S, Geoghegan ND, Sadler JBA, Koester AM, Black HL, Laub M, Miller L, Heffernan L, Simpson JC, Mastick CC, Cooper J, et al.
PeerJ (2020) 8: e8751. 104 202 WB; KD verified; tested species: mouse
Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.
Santa-Marinha L, Castanho I, Silva RR, Bravo FV, Miranda AM, Meira T, Morais-Ribeiro R, Marques F, Xu Y, Point du Jour K, Wenk M, et al.
Cell reports (2020) 3012: 4197-4208.e6. 104 202 WB; tested species: mouse
Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission.
Jäpel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V
Cell reports (2020) 302: 409-420.e6. 104 202 WB; tested species: mouse
Merlin modulates process outgrowth and synaptogenesis in the cerebellum.
Toledo A, Lang F, Doengi M, Morrison H, Stein V, Baader SL
Brain structure & function (2019) : . 104 202 WB; tested species: mouse
Cardiac SNARE Expression in Health and Disease.
Bowman PRT, Smith GL, Gould GW
Frontiers in endocrinology (2019) 10: 881. 104 202 WB; tested species: mouse
Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.
Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, et al.
Molecular neurodegeneration (2019) 141: 43. 104 202 WB; tested species: mouse
Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage.
Yao W, Tambini MD, Liu X, D'Adamio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 104 202 WB; tested species: mouse
Age-related cognitive impairment: Role of reduced synaptobrevin-2 levels in memory and synaptic plasticity deficits.
Orock A, Logan S, Deak F
The journals of gerontology. Series A, Biological sciences and medical sciences (2019) : . 104 202 WB; KD verified; tested species: mouse
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, et al.
Science (New York, N.Y.) (2018) : . 104 202 WB; tested species: rat
α2δ-4 is required for the molecular and structural organization of rod and cone photoreceptor synapses.
Kerov V, Laird JG, Joiner ML, Knecht S, Soh D, Hagen J, Gardner SH, Gutierrez W, Yoshimatsu T, Bhattarai S, Puthussery T, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 104 202 WB; tested species: mouse
Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS
Cell (2018) 1724: 706-718.e15. 104 202 WB, ICC; tested species: mouse
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A, et al.
EMBO molecular medicine (2017) 91: 112-132. 104 202 WB, ICC; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 104 202 WB
BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.
Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ
The Journal of cell biology (2017) 2167: 2151-2166. 104 202 WB; tested species: bon cells
Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway.
Sheehan P, Zhu M, Beskow A, Vollmer C, Waites CL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3633: 8668-86. 104 202 WB; tested species: rat
PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.
Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni RI, Prestigio C, Giovedì S, Onofri F, Mura E, Guarnieri FC, et al.
Cell reports (2016) 151: 117-31. 104 202 WB
Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.
Rajappa R, Gauthier-Kemper A, Böning D, Hüve J, Klingauf J
Cell reports (2016) 146: 1369-1381. 104 202 ICC, WB; tested species: rat
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.
Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D
Nature communications (2015) 6: 7314. 104 202 WB; tested species: human
Characterization of VAMP isoforms in 3T3-L1 adipocytes: implications for GLUT4 trafficking.
Sadler JB, Bryant NJ, Gould GW
Molecular biology of the cell (2015) 263: 530-6. 104 202 WB
Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth.
Ulloa F, Gonzàlez-Juncà A, Meffre D, Barrecheguren PJ, Martínez-Mármol R, Pazos I, Olivé N, Cotrufo T, Seoane J, Soriano E
PloS one (2015) 103: e0119707. 104 202 WB
Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.
Beccano-Kelly DA, Kuhlmann N, Tatarnikov I, Volta M, Munsie LN, Chou P, Cao LP, Han H, Tapia L, Farrer MJ, Milnerwood AJ, et al.
Frontiers in cellular neuroscience (2014) 8: 301. 104 202 WB; tested species: mouse
Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J
Neuroscience (2014) 266: 102-15. 104 202 IHC, WB
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.
Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D
The Journal of biological chemistry (2013) 2889: 6371-85. 104 202 WB; tested species: rat
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.
Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff SC, Lorentz A
European journal of immunology (2008) 383: 855-63. 104 202 WB; tested species: human,rat
Differential distribution of vesicle associated membrane protein isoforms in the mouse retina.
Sherry DM, Wang MM, Frishman LJ
Molecular vision (2003) 9: 673-88. 104 202 WB, IHC
S-SCAM is essential for synapse formation.
Wittenmayer N, Petkova-Tuffy A, Borgmeyer M, Lee C, Becker J, Böning A, Kügler S, Rhee J, Viotti JS, Dresbach T
Frontiers in cellular neuroscience (2023) 17: 1182493. 104 202 ICC; tested species: rat
Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia.
Johnston JL, Reda SM, Setti SE, Taylor RW, Berthiaume AA, Walker WE, Wu W, Moebius HJ, Church KJ
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2022) : . 104 202 ICC; tested species: rat
A Super-Resolved View of the Alzheimer's Disease-Related Amyloidogenic Pathway in Hippocampal Neurons.
Yu Y, Gao Y, Winblad B, Tjernberg LO, Schedin-Weiss S
Journal of Alzheimer's disease : JAD (2021) 832: 833-852. 104 202 ICC; tested species: mouse
CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice.
Halperin D, Stavsky A, Kadir R, Drabkin M, Wormser O, Yogev Y, Dolgin V, Proskorovski-Ohayon R, Perez Y, Nudelman H, Stoler O, et al.
Nature communications (2021) 121: 6187. 104 202 ICC; tested species: mouse
Baseline immunoreactivity before pregnancy and poly(I:C) dose combine to dictate susceptibility and resilience of offspring to maternal immune activation.
Estes ML, Prendergast K, MacMahon JA, Cameron S, Paul Aboubechara J, Farrelly K, Sell GL, Haapanen L, Schauer JD, Horta A, Shaffer IC, et al.
Brain, behavior, and immunity (2020) 88: 619-630. 104 202 ICC; tested species: mouse
Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates.
Jiang H, Esparza TJ, Kummer TT, Zhong H, Rettig J, Brody DL
Scientific reports (2020) 101: 3412. 104 202 ICC; tested species: mouse
Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice.
Hoffmann-Conaway S, Brockmann MM, Schneider K, Annamneedi A, Rahman KA, Bruns C, Textoris-Taube K, Trimbuch T, Smalla KH, Rosenmund C, Gundelfinger ED, et al.
eLife (2020) 9: . 104 202 ICC; tested species: mouse
Syntaxins on granules promote docking of granules via interactions with munc18.
Borisovska M
Scientific reports (2018) 81: 193. 104 202 ICC
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.
Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, et al.
Nature communications (2018) 91: 712. 104 202 ICC; tested species: rat
Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS
Cell (2018) 1724: 706-718.e15. 104 202 WB, ICC; tested species: mouse
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
The EMBO journal (2018) : . 104 202 ICC; tested species: rat
The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T
Scientific reports (2017) 71: 15791. 104 202 ICC; tested species: rat
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A, et al.
EMBO molecular medicine (2017) 91: 112-132. 104 202 WB, ICC; tested species: mouse
Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse.
Tagliatti E, Fadda M, Falace A, Benfenati F, Fassio A
eLife (2016) 5: . 104 202 ICC; tested species: rat
Botulinum neurotoxin type-A enters a non-recycling pool of synaptic vesicles.
Harper CB, Papadopulos A, Martin S, Matthews DR, Morgan GP, Nguyen TH, Wang T, Nair D, Choquet D, Meunier FA
Scientific reports (2016) 6: 19654. 104 202 ICC
Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.
Rajappa R, Gauthier-Kemper A, Böning D, Hüve J, Klingauf J
Cell reports (2016) 146: 1369-1381. 104 202 ICC, WB; tested species: rat
Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
Verstegen AM, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, Corradi A, Valtorta F, Gitler D, Onofri F, Fassio A, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3421: 7266-80. 104 202 ICC; tested species: mouse
Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals.
Orenbuch A, Shalev L, Marra V, Sinai I, Lavy Y, Kahn J, Burden JJ, Staras K, Gitler D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3212: 3969-80. 104 202 ICC
Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations.
Adaikkan C, Joseph J, Foustoukos G, Wang J, Polygalov D, Boehringer R, Middleton SJ, Huang AJY, Tsai LH, McHugh TJ
Nature communications (2024) 151: 2190. 104 202 IHC; tested species: mouse
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors.
Schwab K, Lauer D, Magbagbeolu M, Theuring F, Gasiorowska A, Zadrozny M, Harrington CR, Wischik CM, Niewiadomska G, Riedel G
Brain research bulletin (2024) : 110955. 104 202 IHC; tested species: mouse
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, et al.
Cell systems (2020) : . 104 202 WB, IHC; tested species: mouse
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.
Wegrzynowicz M, Bar-On D, Calo' L, Anichtchik O, Iovino M, Xia J, Ryazanov S, Leonov A, Giese A, Dalley JW, Griesinger C, et al.
Acta neuropathologica (2019) : . 104 202 IHC; tested species: mouse
Adult-born neurons facilitate olfactory bulb pattern separation during task engagement.
Li WL, Chu MW, Wu A, Suzuki Y, Imayoshi I, Komiyama T
eLife (2018) 7: . 104 202 IHC; tested species: mouse
Identification of Serotonergic Neuronal Modules that Affect Aggressive Behavior.
Niederkofler V, Asher TE, Okaty BW, Rood BD, Narayan A, Hwa LS, Beck SG, Miczek KA, Dymecki SM
Cell reports (2016) 178: 1934-1949. 104 202 IHC; tested species: mouse
Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy.
Ferecskó AS, Jiruska P, Foss L, Powell AD, Chang WC, Sik A, Jefferys JG
Brain structure & function (2015) 2202: 1013-29. 104 202 IHC
Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning.
Sakamoto M, Ieki N, Miyoshi G, Mochimaru D, Miyachi H, Imura T, Yamaguchi M, Fishell G, Mori K, Kageyama R, Imayoshi I, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3417: 5788-99. 104 202 IHC; tested species: mouse
Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J
Neuroscience (2014) 266: 102-15. 104 202 IHC, WB
MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.
Larimore J, Ryder PV, Kim KY, Ambrose LA, Chapleau C, Calfa G, Gross C, Bassell GJ, Pozzo-Miller L, Smith Y, Talbot K, et al.
PloS one (2013) 86: e65069. 104 202 IHC; tested species: mouse
Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion.
Nakashiba T, Cushman JD, Pelkey KA, Renaudineau S, Buhl DL, McHugh TJ, Rodriguez Barrera V, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, et al.
Cell (2012) 1491: 188-201. 104 202 IHC; tested species: mouse
Differential distribution of vesicle associated membrane protein isoforms in the mouse retina.
Sherry DM, Wang MM, Frishman LJ
Molecular vision (2003) 9: 673-88. 104 202 WB, IHC
Enhanced synaptic protein visualization by multicolor super-resolution expansion microscopy.
Eilts J, Reinhard S, Michetschläger N, Werner C, Sauer M
Neurophotonics (2023) 104: 044412. 104 202 ExM; tested species: mouse
Spatial proteomics in neurons at single-protein resolution.
Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, et al.
Cell (2024) 1877: 1785-1800.e16. 104 202 DNA-PAINT; tested species: rat
A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation.
Oorschot V, de Wit H, Annaert WG, Klumperman J
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (2002) 508: 1067-80. 104 202 EM
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 104 202 ELISA
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Background

Synaptobrevins/VAMPs represents a family of integral membrane proteins of 11-13 kDa with the N-terminal region exposed to the cytoplasm and a C-terminal transmembrane domain. Two isoforms were identified in the mammalian CNS, synaptobrevin1 (VAMP1 or p18-1) and synaptobrevin2 (VAMP2 or p18-2) that differ in their distribution within different brain regions.
Synaptobrevin1 is highly conserved between vertebrates and invertebrates. It is a major constituent of synaptic vesicles and peptidergic secretory granules in all neurons examined so far. In addition, it is present on secretory granules of neuroendocrine cells. Low levels of synaptobrevin2 are present in many other tissues where the protein resides on specialized microvesicles.
In non-neuronal cells the third isoform, cellubrevin (VAMP3), is present where it is localized to an endosomal membrane pool.
Synaptobrevin/VAMP is an essential component of the exocytotic fusion machine, related to a larger protein family referred to as v-SNAREs. It is the sole target for tetanus and several of the botulinal neurotoxins which cleave the protein at single sites in the C-terminal portion of the molecule.
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