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Cat. No. 102 308 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
Applications | |
Clone | Gp44E3 |
Subtype | IgG2 (κ light chain) |
Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of rat Synaptoporin (UniProt Id: P22831) |
Reactivity |
Reacts with: mouse (Q8BGN8), rat (P22831). Other species not tested yet. |
Matching control protein/peptide | 102-1P |
Remarks |
The antibody is a chimeric antibody based on the monoclonal mouse antibody clone 44E3. The constant regions of the heavy and light chains have been replaced by guinea pig specific sequences. Therefore, the antibody can be used with standard anti-guinea pig secondary reagents. The antibody has been expressed in mammalian cells. |
Data sheet | 102_308.pdf |
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Synaptoporin, also known as synaptophysin2 and p38-2, is highly homologous to synaptophysin1 but encoded by a different gene. Like synaptopysin1, synaptoporin contains four transmembrane regions and a short cytoplasmic tail. Unlike synaptophysin1, it is not glycosylated.
The distributions of synaptophysin1 and synaptoporin are different. Synaptophysin1 is more uniformly expressed whereas synaptoporin is particularly enriched in mossy fiber synapses in the hippocampus. It is thus an excellent marker for subsets of synapses.