Cat. No.: 160 318
Amount: 50 µg
Price:
$420.00
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| Cat. No. 160 318 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Gp72G2 |
| Subtype | IgG2 (κ light chain) |
| Immunogen | Recombinant protein corresponding to residues near the C-terminal half of human Homer1b (UniProt Id: Q86YM7-1) |
| Reactivity |
Reacts with: human (Q86YM7-1), mouse, rat. Other species not tested yet. |
| Remarks |
This antibody is a chimeric antibody based on the monoclonal mouse antibody SY-72G2. The constant regions of the heavy and light chains have been replaced with guinea pig specific sequences. The antibody can therefore be used with standard anti-guinea pig secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 160_318.pdf |
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Homer is a scaffolding protein localized in the postsynaptic density (PSD) and is highly enriched at excitatory synapses. It acts as a molecular adaptor by binding to metabotropic glutamate receptors (mGluRs) (1), TRPC1 channels, Shank family proteins (2), and several other signaling molecules, organizing them into distinct clusters and thereby establishing specific signaling domains within the PSD.
By cross-linking these proteins, Homer plays a crucial role in structural and functional organization of the PSD, contributing to the maturation of dendritic spines and the regulation of synaptic plasticity. Homer and Shank, in particular, form a mesh-like matrix that serves as a platform for assembly of other PSD proteins (3).
There are three main Homer isoforms—Homer1, Homer2, and Homer3—each of which is subject to alternative splicing, producing multiple splice variants such as a, b, c, and d. These variants can have distinct functional properties, and their dynamic redistribution at synapses is involved in remodeling the PSD in response to neuronal activity (4).
Emerging evidence suggests broader roles for Homer1b/c beyond synaptic scaffolding, including in non-neuronal contexts, although their specific involvement in cancer remains unclear (5).